From: Neurodevelopmental outcome of Italian preterm ELBW infants: an eleven years single center cohort
Variable | Univariate Analysis | Multivariate Analysis | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Minor Sequelae | Major Sequelae | Minor Sequelae | Major Sequelae | |||||||||
RRR | CI 95% | p | RRR | CI 95% | p | RRR | CI 95% | p | RRR | CI 95% | p | |
Female Sex | 0.64 | 0.29–1.43 | 0.276 | 0.41 | 0.18–0.96 | 0.040* | ||||||
Birthweight (g) | 1 | 1–1 | 0.187 | 0.99 | 0.99–1.00 | 0.001* | ||||||
Gestational age (weekd) | 0.90 | 0.74–1.08 | 0.265 | 0.66 | 0.52–0.83 | 0.001* | ||||||
Bronchopulmonary dysplasia (BPD) | 3.17 | 1.34–7.51 | 0.009* | 6.26 | 2.23–17.59 | 0.001* | 2.95 | 1.19–7.33 | 0.020* | 4.36 | 1.48–12.86 | 0.008* |
Postnatal steroid | 3.10 | 1.34–7.16 | 0.008* | 2.29 | 0.95–5.49 | 0.063 | ||||||
Red blood cells transfusion | 1.43 | 0.53–3.81 | 0.480 | 4.63 | 1.04–20.67 | 0.045* | ||||||
CRIB | 1.10 | 0.99–1.23 | 0.084 | 1.19 | 1–07-1.34 | 0.002* | ||||||
Birthweight recovery (days) | 1.06 | 0.97–1.15 | 0.251 | 1.12 | 1.03–1.21 | 0.010* | 1.03 | 0.95–1.13 | 0.426 | 1.06 | 0.97–1.17 | 0.186 |
Total Parenteral Nutrition (days) | 1.01 | 0.97–1.06 | 0.654 | 1.06 | 1.01–1.10 | 0.011* | ||||||
cUS findings: | ||||||||||||
Mildly abnormal | 5.40 | 0.69- 42–32 | 0.109 | 3.24 | 0.40–26.03 | 0.269 | ||||||
Severely abnormal | 6.91 | 0.68–69.86 | 0.102 | 20.73 | 2.36–181.71 | 0.006* | 4.03 | 0.38–43.14 | 0.249 | 10.22 | 1.08–96.78 | 0.043* |
Abnormal neurological examination at 40 wks PMA | 4.07 | 1.70–9.74 | 0.002* | 5.49 | 2.15–14.00 | < 0.001* |