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Table 4 Univariate and multivariate analysis of risk factors for adverse neurodevelopmental outcome

From: Neurodevelopmental outcome of Italian preterm ELBW infants: an eleven years single center cohort

Variable

Univariate Analysis

Multivariate Analysis

Minor Sequelae

Major Sequelae

Minor Sequelae

Major Sequelae

RRR

CI 95%

p

RRR

CI 95%

p

RRR

CI 95%

p

RRR

CI 95%

p

Female Sex

0.64

0.29–1.43

0.276

0.41

0.18–0.96

0.040*

      

Birthweight (g)

1

1–1

0.187

0.99

0.99–1.00

0.001*

      

Gestational age (weekd)

0.90

0.74–1.08

0.265

0.66

0.52–0.83

0.001*

      

Bronchopulmonary dysplasia (BPD)

3.17

1.34–7.51

0.009*

6.26

2.23–17.59

0.001*

2.95

1.19–7.33

0.020*

4.36

1.48–12.86

0.008*

Postnatal steroid

3.10

1.34–7.16

0.008*

2.29

0.95–5.49

0.063

      

Red blood cells transfusion

1.43

0.53–3.81

0.480

4.63

1.04–20.67

0.045*

      

CRIB

1.10

0.99–1.23

0.084

1.19

1–07-1.34

0.002*

      

Birthweight recovery (days)

1.06

0.97–1.15

0.251

1.12

1.03–1.21

0.010*

1.03

0.95–1.13

0.426

1.06

0.97–1.17

0.186

Total Parenteral Nutrition (days)

1.01

0.97–1.06

0.654

1.06

1.01–1.10

0.011*

      

cUS findings:

 Mildly abnormal

5.40

0.69- 42–32

0.109

3.24

0.40–26.03

0.269

      

 Severely abnormal

6.91

0.68–69.86

0.102

20.73

2.36–181.71

0.006*

4.03

0.38–43.14

0.249

10.22

1.08–96.78

0.043*

 Abnormal neurological examination at 40 wks PMA

4.07

1.70–9.74

0.002*

5.49

2.15–14.00

 < 0.001*

      
  1. p values < 0.05 indicating statistical significance of the association between the variable under study and the neurological sequelae are highlighted with an asterisk