Epstein-Barr virus-associated acute pancreatitis: a clinical report and review of literature

Table II Clinical data of adult cases with EBV-associated acute pancreatitis reported in literature

Reference	Age/sex	Mononucleosis symptoms	Gastrointestinal symptoms	EBV diagnosis	Amylase-lipase	Imaging	Other complications	Therapy	Outcome
Jahann et al. 2012 [19]	22y/M	Yes	Abdominal pain	VCA IgM positivity	330–2300 U/l	NR	No	Symptomatic	Recovered
Cook et al. 2015 [20]	25y/M	No	Abdominal pain, nausea, fever	VCA IgM positivity	NA-429 U/l	CT: pancreatic edema	Cholestatic hepatitis, pleural effusions, ascites	Fasting, parenteral nutrition, analgesics	Recovered
Singh et al. 2015 [21]	21y/F	Yes	Abdominal pain, vomiting, nausea	VCA IgM positivity	NA-4301 U/l	CT: pancreatic edema	Autoimmune hemolytic anemia	Symptomatic, prednisone	Recovered
Zhu et al. 2017 [9]	35y/F	Yes	Abdominal pain, vomiting	VCA IgM positivity	1300–1450 U/l	CT: pancreatic edema	Hepatitis, pneumonia	Fasting, parenteral nutrition, amoxicillin-clavulanate, acyclovir	Recovered
Fiani et al. 2021 [22]	35y/F	No	Abdominal pain, fever	VCA IgM and IgG positivity, serum EBV DNA	129/408 U/l	CT: enlargement of the pancreas	Cholestatic hepatitis, pneumonia with pleural effusions	Symptomatic, linezolid, meropenem, oseltamivir, acyclovir, methylprednisolone	Recovered
Huang et al. 2021 [23]	45y/F	No	Abdominal pain	Serum EBV DNA	Increased up to three times the normal limit	CT: pancreatic necrosis	Pericardial and pleural effusions, gastritis, MOF	Symptomatic	Dead

Abbreviations: y years, M Male, F Female, NA Not available, NR Not reported, MOF Multi-organ failure

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