Table 3 Clinical trials of nutrition interventions on children with CF
Author | Type of Study | N. of children | Test | Time point | Results |
|---|---|---|---|---|---|
Zahra Gorji et al. Diabetes Metab Syndr. 2020 [44] | Randomized controlled trial | 44 CF children and adolescents | Randomized to receive for 3 months either a high fat, high-calorie diet (n = 22) or a low glycemic index/high fat, high-calorie diet (n = 22) | Lipid profiles, insulin, fasting blood glucose, and glycated hemoglobin at baseline and after the intervention | Adherence to a low glycemic index/high fat, high-calorie diet can improve glycemic indices |
Virginia A. Stallings. Plos One. 2020 [45] | Randomized controlled trial | 66 with baseline CFA | A three-month treatment with a novel oral structured lipid supplement | Baseline and 3-month evaluations, CFA and height, weight and BMI Z-scores | Subjects in low CFA subgroup had improved CFA (p = 0.002), and reduced stool fat loss |
L Ellis J Pediatr. 1998 [42] | Clinical trial | 23 CF infants | Randomized to receive a hydrolysate formula or a cow's milk-based formula | Monitored at 1 month and then every 3 months for 1 year | Same energy intake, growth velocity and nutritional status with each formula |