Changes in liver enzymes are associated with changes in insulin resistance, inflammatory biomarkers and leptin in prepubertal children with obesity

Table 3 Single correlation coefficients (r) between changes in liver enzymes and different variables

	Δ ALT		Δ AST		Δ BChE		Δ ALT/AST
	r	p	r	p	r	p	r	p
Δ BMI	0.3054	0.0149	0.2577	0.0435	0.5404	< 0.0001	0.2705	0.0331
Δ SDS-BMI	0.2691	0.0339	0.1669	0.1910	0.5150	< 0.0001	0.2564	0.0456
Δ WC	0.3436	0.0058	0.2869	0.0226	0.4607	0.0001	0.2638	0.0372
Δ Glucose	0.0270	0.8336	-0.1148	0.3703	-0.1881	0.1398	0.0618	0.6306
Δ Insulin	0.2602	0.0381	0.1243	0.3316	0.3036	0.0156	0.0779	0.5734
Δ HOMA-IR	0.2710	0.0329	0.1455	0.2550	0.2762	0.0318	0.0292	0.8200
Δ SBP	-0.2256	0.0731	-0.2278	0.0742	0.1192	0.3522	-0.1052	0.4117
Δ DBP	-0.2326	0.0628	-0.1702	0.1822	0.0543	0.6720	-0.2414	0.0572
Δ Total cholesterol	-0.0119	0.9261	0.1125	0.3801	0.1682	0.1876	-0.0783	0.5421
Δ Triglycerides	0.0623	0.6274	-0.0719	0.5755	0.4584	0.0002	0.0813	0.5266
Δ HDL cholesterol	-0.0290	0.8212	-0.0167	0.8966	-0.0116	0.9282	0.0255	0.8428
Δ CRP	0.3424	0.0061	0.2815	0.0264	0.3181	0.0115	0.2677	0.0354
Δ IL-6	0.2697	0.0337	0.2839	0.0242	0.0249	0.8462	0.1718	0.1818
Δ NLR	0.2574	0.0438	0.2348	0.0650	0.2702	0.0334	0.1540	0.2318
Δ PLR	0.3151	0.0134	0.2684	0.0351	0.2672	0.0364	0.2679	0.0353
Δ sICAM-1	0.0244	0.8497	0.1150	0.3693	0.0931	0.4678	-0.0135	0.9166
Δ Leptin	0.3264	0.0096	0.3039	0.0167	0.5291	< 0.0001	0.3677	0.0031

Results after treatment for nine months in the children with obesity group (n = 63). Changes (Δ) in different variables are expressed as values after 9 months of treatment minus baseline values
ALT Alanine aminotransferase, AST Aspartate aminotransferase, BChE Butyryl cholinesterase, BMI Body mass index, WC Waist circumference, HOMA-IR Homeostasis model assessment for insulin resistance, SBP Systolic blood pressure, DBP Diastolic blood pressure, CRP C-reactive protein, IL-6 Interleukin-6, NLR Neutrophil-to-lymphocyte ratio, PLR Platelet-to-lymphocyte ratio, sIACM-1 Soluble intercellular adhesion molecule-1

ISSN: 1824-7288