Table 1 Characteristics of the included studies
Author | Year | Study design | Study period | Setting | Funding | Country | sample size | Groups | Sex [male, %] | Age[yr, median (IQR) or mean (SD)] | Complete KD cases[%] | Recurrent cases[%] | Received IVIG[%] | Outcomes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cai | 2022 | Cohort | 2018.01- 2020.12 | Chengdu Women’s and Children’s Central Hospital | No | China | 965 | Early group (day 1–4); Conventional group (day 5–7); Conventional group (day 8–10); Late group (after day 10). | 60.5 | 2.3 (1.6) | 91.5 | 0 | 100.0 | ①②③④ |
Li | 2021 | Cohort | 2015.01- 2017.12 | Guangzhou Women and Children’s Medical Center、the First Affiliated Hospital of Sun Yat-sen University | Yes | China | 1281 | Group 1 (≤ 4days); Group 2 (5–7 days); Group 3 (8-10days); Group 4 (> 10days). | 63.7 | 1.0 (0.9-3.0) | NA | NA | 100.0 | ①②③④ |
Yazdi | 2021 | Cohort | 2012.01- 2015.12 | Imam Khomeini Hospital | No | Iran | 31 | Early detection group (≤ 10days); Late detection group (>10days). | 54.8 | 3.6 (0.2) | 100.0 | NA | 100.0 | ② |
Ha | 2020 | Cohort | 2008.01- 2014.12 | Korea University Medical Center | No | Korea | 555 | Early (≤ 3 days); Usual (4–5 days); Late (≥ 6 days). | 57.8 | NA | NA | NA | 100.0 | ①②③ |
Shiozawa | 2018 | Cohort | 2006.08- 2013.01 | Eight hospitals in Japan | No | Japan | 339 | Early treatment group (by day 4 of illness); Conventional treatment group (on day 5). | 36.6 | 1.8 | 100.0 | 0 | 100.0 | ①② |
Kuwabara | 2018 | Cohort | 2011.01- 2012.12 | 22nd nationwide survey of KD in Japan | Yes | Japan | 20,845 | Early (4 days or less); Conventional (5 to 7 days); Late (8 to 10 days). | 42.2 | NA | 84.8 | 0 | 100.0 | ①② |
Downie | 2017 | Cohort | 1990.01- 2013.12 | Hospital for Sick Children | Yes | Canada | 1269 | Prompt treatment (≤ 10 days); Delayed treatment (>10 days). | 61.5 | (1.5-6.0) | 73.0 | NA | 100.0 | ①②③ |
Mohammadzadeh | 2016 | Cohort | 2006–2011 | Amirkola Children’s Hospital | Yes | Iran | 100 | Early (within 10 days); Late (> 10 days). | 61.0 | 2.8 (2.6) | 77.0 | NA | 100.0 | ② |
Chen | 2015 | Cohort | 2008.01- 2012.12 | 50 hospitals in Shanghai | Yes | China | 2304 | Early (< 5 days); Conventional (5 to 10 days); Late (> 10 days). | 66.2 | 2.3 (0.1–11.7) | 72.9 | 0.9 | 94.3 | ② |
Bal | 2014 | Cohort | 1999.01- 2011.12 | Jersey Shore University Medical Center | No | USA | 106 | Early (within 10 days); Late (> 10 days). | 63.2 | (0–18.0) | 91.5 | NA | 100.0 | ①②③④ |
Wang | 2014 | Cohort | 2010.02- 2013.08 | Logistic University of PAPF | No | China | 60 | Observation group (>5days); Control group (applied immediately). | 51.7 | (0. 5–10.0) | NA | NA | 100.0 | ① |
Callinan | 2012 | Cohort | 2000–2009 | US Centers for Disease Control and Prevention’s national KS surveillance system | Yes | USA | 2056 | Before illness day 5; After illness day 5. | 59.6 | < 18 | 98.0 | 1.4 | 98.0 | ② |
Sittiwangkul | 2011 | Cohort | 2000–2008 | Chiang Mai University Hospital | No | Thailand | 170 | Group I (≤ 10 days of fever); Group II (>10 days of fever). | 60.0 | 21.8 (1.4) | 74.7 | NA | 91.2 | ①② |
Du | 2009 | Cohort | 2000–2004 | 45 hospitals in Beijing | Yes | China | 1052 | Early (1-4days); Conventional (5-9days); Late (≥ 10days). | 64.6 | (0.2-l3.8) | NA | NA | 100.0 | ①②③④ |
Muta | 2004 | Cohort | 1997-1998 1999-2000 | The database from nationwide surveys in Japan | Yes | Japan | 8751 | Early group (1-4days); Conventional group (5-9days). | 59.1 | (0.1–21.3) | 85.9 | 0 | 100.0 | ①② |
Li | 2006 | Cohort | 1998.01- 2005.03 | Affiliated Taihe Hospital of Yunyang Medical College | No | China | 41 | Group A (≤ 5days); Group B (6-10days); Group C (>10days). | 56.1 | (0.5-6.0) | NA | NA | 100.0 | ①②④ |
Hsieh | 2004 | Cohort | 1993–2003 | Veterans General Hospital-Kaohsiung | Yes | China | 162 | Before illness ady 5; After illness day 5. | 61.7 | 1.79 (1.58) | NA | NA | 100.0 | ①② |
Nomura | 2002 | Cohort | 1989.01- 1998.12 | Kagoshima City Medical Association Hospital | No | Japan | 125 | Group A (from the second to the fourth day); Group B (from the fifth day to ninth). | 56.8 | (0.2–11.3) | 100.0 | NA | 100.0 | ①②③④ |
Muta | 2012 | Case- control | 2007.01- 2008.12 | The database of the 20th nationwide survey of KD in Japan | Yes | Japan | 150 | Late IVIG (Days 11–20); Conventional IVIG (Days 4–8). | 50.0 | (0.2–7.9) | 91.3 | NA | 100.0 | ①②③④ |
Fong | 2004 | Case- control | 1994–1999 | Princess Margaret Hospital | No | China | 81 | Case group (before day 5 of fever); Control group (on day 5 of fever or after). | 61.7 | NA | NA | NA | 100.0 | ①②③ |
Tse | 2002 | Case- control | 1987–1999 | Hospital for Sick Children | Yes | Canada | 178 | Case group (≤ 5 days of fever); Control group (between 6 and 9 days of fever). | 62.9 | NA | 100.0 | NA | 100.0 | ①②③④ |
Kong | 2021 | RCT | 2018.01- 2019.12 | Huainan Women’s & Children’s Hospital | No | China | 61 | Observation group (5-7days); Control group (8-10days). | 55.7 | (0.4-6.0) | NA | NA | 100.0 | ①②③④ |
Wu | 2019 | RCT | 2015.05- 2018.10 | Mianzhu People’s Hospital | No | China | 123 | Observation group (1-5days); Control group1 (5-10days); Control group1 (>10days). | 56.9 | 3.46 (0.38) | 100.0 | NA | 100.0 | ①②③④ |
Xiong | 2019 | RCT | 2015.05- 2018.02 | The First People’s Hospital of Guangshui City | No | China | 70 | Observation group (5-10days); Control group (>10days). | 60.0 | (0.6–11) | NA | NA | 100.0 | ② |
Shao | 2018 | RCT | 2011.09- 2017.06 | Wenling First People’s Hospital | No | China | 64 | Observation group (5-9days); Control group (10-14days). | 59.4 | NA | 0 | NA | 100.0 | ②④ |
An | 2017 | RCT | 2015.01- 2015.12 | The Affiliated Hospital of Hebei University | No | China | 110 | Early (1-5days); Conventional (5-10days); Late (≥ 10days). | 53.6 | (0.4–12) | NA | 0 | 100.0 | ①② |
Li | 2013 | RCT | 2009.01- 2010.10 | Shuangliu Second People’s Hospital | No | China | 90 | Group I (1-4days); Group II (5-9days); Group III (9-13days). | 48.9 | (0.6–10) | NA | NA | 100.0 | ①② |