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Table 4 Different outcome in the studied groups

From: Citicoline in hypoxic ischemic encephalopathy in neonates: a randomized controlled trial

Parameters

Citicoline group

Control group

P

Number of patients with seizures during trteatment: N (%)

8 (20%)

15 (37.5%)

0.04

Type of seizures: N (%)

   

 -No seizure

32 (80%)

25 (62.5%)

0.092

 -Focal

2 (5%)

4 (10%)

 -GTCs

6 (15%)

7 (17.5%)

 -Focal clonic

0 (0%)

1 (2.5%)

 -Myoclonic

0 (0%)

1 (2.5%)

 - Clonic

0 (0%)

1 (2.5%)

- Focal & GTCs

0 (0%)

1 (2.5%)

 

Seizure duration (min)

2 (0.2 – 15.0)

6 (1 – 15.0)

0.02

Number of patients with post discharge seizure

2 (5.0%)

11 (27.5%)

0.006

Duration of NICU stay (days)

25.58 ± 9.36

34.43 ± 13.53

0.001

Number of patients who needed inotropes

9 (22.5%)

20 (50%)

0.011

Duration of inotropes(hours)

12.0 (1.0 – 72.0)

24.0 (3.0 – 96.0)

0.032

Duration of MV (days)

10.85 ± 3.21

21.50 ± 6.64

 < 0.001

Cranial US on discharge: N (%)

   

-Normal

- Abnormal

32 (80%)

4 periventricular leukoencephalopathy (10%)

4 periventricular leukomalacia (10%)

22 (55%)

9 periventricular leukoencephalopathy (22.5%)

8 periventricular leukomalacia (20%)

1 cortical atrophy (2.5%)

0.006

MRI brain on discharge: N (%)

   

-Normal

- Abnormal

30 (75%)

4 periventricular leukoencephalopathy (10%)

4 periventricular leukomalacia (10%)

2 cortical atrophy (5%)

(1 of them had caudate nucleus changes)

19 (47.5%)

21 (52.5%)

9 periventricular leukoencephalopathy (22.5%)

8 periventricular leukomalacia (20%)

4 cortical atrophy (10%)

(1 of them had focal changes in the lateral thalamus and lentiform nucleus)

0.001

  1. GTCs generalized tonic clonic convulsions, NICU neonatal intensive care unit, MV mechanical ventilation, US ultrasound, MRI magnetic resonance imaging