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Table 3 Disease severity assessment of the L-T4 treated and untreated THOP patients

From: Clinical indicators that influence a clinician’s decision to start L-thyroxine treatment in prematurity with transient hypothyroxinemia

 

L-T4 Treated

L-T4 Untreated

p valuea

Participants, n

36

47

 

Medicine

 Vancomycin + amikacin

10 (28)

5 (11)

0.044

 Ampicillin + gentamicin

13 (36)

26 (55)

0.082

 Caffeine

34 (94)

36 (77)

0.027

 Dobutamine

6 (17)

4 (9)

0.258

 Dopamine

15 (42)

7 (15)

0.006

Clinical-diagnosis

 Sepsis

5 (14)

5 (11)

0.652

 PDA

9 (25)

8 (17)

0.372

 RDS

28 (78)

23 (49)

0.007

 IVH

18 (50)

11 (23)

0.022

 BPD

23 (64)

14 (30)

0.002

 ROP

1 (3)

2 (4)

0.363

 NEC

1 (3)

1 (2)

1.000

Clinical interventions

 Central catheter

35 (97)

34 (72)

0.003

 ES transfusion

15 (42)

12 (26)

0.120

 TS transfusion

7 (19)

3 (6)

0.070

 FFP transfusion

18 (50)

11 (23)

0.012

 Ventilator support

22 (61)

18 (38)

0.039

 NIV support

24 (67)

28 (60)

0.508

  1. Categorical data are given as frequency and (%). Bolds are statistically significant (p < 0.05)
  2. When THOP cases were compared in terms of disease severity of L-T4 treated and untreated group; vancomycin + amikacin, caffeine, dopamine, RDS, IVH, BPD, central catheter, FFP transfusion, ventilator support were statistically significant (P < 0.05)
  3. Abbreviations: THOP transient hypothyroxinemia of prematurity, RDS respiratory distress syndrome, IVH intraventricular haemorrhage, BPD bronchopulmonary dysplasia, ROP premature retinopathy, NEC necrotizing enterocolitis, ES erythrocyte suspension, TS thrombocyte suspension, FFP fresh frozen plasma, NIV non-invasive ventilation
  4. aChi-square test