Table 2 summary of the different papers which report the use of cimetidine in EPP in pediatric population
From: Erythropoietic protoporphyria: case reports for clinical and therapeutic hints
Author, Year | Daily dose/duration | Side effects reported | Sun tolerance during treatment | erythrocytes PpIX level | No patient/age | How was evaluated the photosensitivity |
|---|---|---|---|---|---|---|
Heerfordt10, 2022 | 1200 mg/4 months | None | increased | 41% decrease after 2 months 19% decrease after 4 months | 1/ N.A. | questionnaire about (i) overall effect on photosensitivity (ii) time spent outside (iii) time to first photosensitivity symptoms (iiii)edema (iiiii) protective clothing |
Kiberd,11 2018 | 30 mg/kg / Not available | None | Increased | N.A. | 1/ 4-year-old | Subjective increased tolerance |
Tu, 12 2016 | 30–40 mg/kg/ > 2 years | None | Increased | Data available for one patient in which 37% decrease after 1 year of treatment | 3/ median age 9-year-old | Objective: improvement of actinic photodamage of the skin Subjective: - increased of number of hours of outdoor activities - Reduced the use of analgesic drugs |