Fig. 5

Correlation-based network of positive ion mode. Each point represents a significantly differential metabolite. Red points and blue points are upregulated and downregulated metabolites of interest, respectively. The sizes of the points increase with degree. The positive and negative relationships between metabolites with Spearman correlation coefficient|r| > 0.8 and P < 0.05 are shown in red and blue lines respectively. The solid lines represent the correlations of interest. The thickness of lines represents absolute correlation coefficient. The line becomes thicker as the absolute correlation coefficient increases. GABA, gamma-aminobutyric acid; PC(P-18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)), 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine; PC(18:0/18:2(9Z,12Z)), 1-stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine; LPC (16:0), 1-palmitoyl-sn-glycero-3-phosphocholine; LPC (18:0), 1-stearoyl-sn-glycerol 3-phosphocholine