Respiratory syncytial virus-associated hospitalizations among children: an Italian retrospective observational study

Table 2a Univariate/multivariate analysis assessing association between demographic/clinical characteristics and severe RSV-disease. Policlinico-Foggia-Hospital, Apulia region, Italy, 2011 − 2020

	Very severe RSV disease*		Univariate Analysis			Multivariate Analysis
	Yes (N = 208)	No (N = 624)	Univariate Analysis			Multivariate Analysis
Characteristics	n (%)/mean (SD)	n (%)/mean (SD)	OR	95% CI	p value	OR	95% CI	p value
Sex, n (%)
Male	119 (57.2)	351 (56.2)			Ref.
Female	89 (42.8)	273 (43.8)	1.03	0.75–1.45	0.8086
Age group (months), mean (SD)	1.8 (8.7)	10.9 (14.7)			0.0000	14.8	8.30–26.31	0.000**
LOS (days), mean (SD)	10.02 (17.47)	5.59 (14.87)			0.0002	1.01	1.0–1.02	0.030***
RSV subtype, n (%)
A	116 (55.8)	358 (57.4)	-	-	Ref.
B	92 (44.2)	266 (42.6)	0.94	0.67–1.30	0.6860
Delivery during the RSV infection season	182 (87.5)	350 (56.1)	5.5	3.49–8.86	0.0000	1.4	0.82–2.53	0.192
Comorbid condition
Pediatric CCCs	51 (24.5)	74 (11.9)	2.4	1.58–3.65	0.0000	1.0	0.42–2.44	0.957
History of prematurity	41 (19.7)	29 (4.6)	5.0	2.9–8.6	0.0000	4.4	1.57–12.11	0.005

CCCs: complex chronic conditions; CI: confidence interval; LOS: length of stay; RSV: respiratory syncytial virus; SD: standard deviation
*Al least one condition: neonatal intensive care unit admission, mechanical ventilation, respiratory therapy, extracorporeal membrane oxygenation, death
**Age 0–2 months vs. >2 months
***LOS included in the model as days

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