Critical period of oxygen supplementation and invasive ventilation: implications for severe retinopathy of prematurity

Table 2 Time-weighted average FiO₂ at each PMA and PNA

PMA	No treated ROP (n = 189)	Treated ROP (n = 98)	p-value	PNA	No treated ROP (n = 189)	Treated ROP (n = 98)	p-value
24 weeks	0.36 (0.21–0.73)	0.26 (0.24–0.34)	0.517	1st week	0.23 (0.22–0.26)	0.25 (0.22–0.29)	0.003
25 weeks	0.24 (0.22–0.28)	0.26 (0.22–0.36)	0.301	2nd week	0.23 (0.21–0.25)	0.27 (0.24–0.33)	< 0.001
26 weeks	0.24 (0.22–0.29)	0.28 (0.23–0.35)	0.039	3rd week	0.25 (0.21–0.27)	0.31 (0.27–0.38)	< 0.001
27 weeks	0.24 (0.22–0.29)	0.27 (0.24–0.32)	0.004	4th week	0.25 (0.22–0.29)	0.33 (0.27–0.38)	< 0.001
28 weeks	0.24 (0.22–0.3)	0.27 (0.22–0.34)	0.047	5th week	0.25 (0.21–0.3)	0.34 (0.28–0.39)	< 0.001
29 weeks	0.25 (0.22–0.3)	0.27 (0.23–0.34)	0.031	6th week	0.25 (0.21–0.3)	0.33 (0.27–0.37)	< 0.001
30 weeks	0.25 (0.22–0.31)	0.28 (0.23–0.36)	0.014	7th week	0.25 (0.21–0.3)	0.3 (0.26–0.36)	0.002
31 weeks	0.25 (0.22–0.31)	0.26 (0.22–0.34)	0.160	8th week	0.26 (0.23–0.3)	0.29 (0.24–0.34)	0.012
32 weeks	0.25 (0.21–0.32)	0.29 (0.23–0.38)	0.017	9th week	0.26 (0.22–0.3)	0.3 (0.24–0.35)	0.014
33 weeks	0.25 (0.21–0.33)	0.28 (0.24–0.37)	0.004	10th week	0.26 (0.22–0.32)	0.29 (0.25–0.32)	0.069
34 weeks	0.25 (0.21–0.31)	0.27 (0.24–0.35)	0.010	11th week	0.28 (0.25–0.31)	0.28 (0.25–0.32)	0.583
35 weeks	0.26 (0.21–0.32)	0.27 (0.24–0.33)	0.223	12th week	0.3 (0.25–0.32)	0.29 (0.25–0.32)	0.944

Values are presented as median (interquartile range). FiO₂, Fraction of inspired oxygen; PMA, postmenstrual age; PNA, postnatal age; ROP, retinopathy of prematurity

ISSN: 1824-7288