Fig. 1

Biochemical analysis of SNP sites in FLT4 and HYDIN genes. (A): Linkage disequilibrium analysis of SNPs in the FLT4 gene: The value shown in the haplotype block diagram is D’, and rs383985 is located at the position of block 198. (B): An enlarged view of the linkage region, which is located in exons 4–8 of the FLT4. (C): The rs1774266 protein function prediction of the HYDIN gene. The mutation is located at the 2042 point of the protein structure (the beginning of the Hydin Adenylate kinase-like domain), and the amino acid is changed from histidine to glutamine. (D): Conservation analysis of the rs1774266 protein sequence, the arrow is the rs1774266 position