Association study of FLT4 and HYDIN single nucleotide polymorphisms with atrial septal defect susceptibility in the Han Chinese population of Southwest China

Table 1 Comparison of the gene frequency of 10 SNPs in the ASD and normal populations

Gene	SNP	Minor/Major	MAF(ASD)	MAF(control)	P-value	HWE-P
DNAH5	rs12659700	T/C	0.1286	0.1094	0.2071	0.523
FLT4	rs383985	C、T/G	0.2262	0.1718	0.003*	0.246
IQGAP1	rs2589941	C/T	0.1619	0.1626	0.9691	0.272
COL5A1	rs3124309	C/T	0.5048	0.4939	0.6432	0.895
FN1	rs6707530	T/G	0.2583	0.2352	0.2529	0.180
COL4A1	rs598893	C/T	0.2095	0.2239	0.4578	0.845
HYDIN	rs7198975	A/G	0.4274	0.3845	0.0462	0.100
	rs1774266	A/G	0.4274	0.3845	0.0462	0.113
B9D1	rs11650112	T/C	0.1333	0.1247	0.5856	1.000
LAMC3	rs710074	C/A	0.3536	0.3497	0.8629	0.06

P value in boldface indicates statistical significance. Abbreviations: SNP, single nucleotide polymorphism; MAF(ASD), Minor allele frequency in ASD patients; MAF (control), Minor allele frequency in normal controls; HWE-P, P value of Hardy–Weinberg equilibrium. P*<0.005

ISSN: 1824-7288