Volume 40 Supplement 2

Proceedings of the XX National Congress of the Italian Society of Neonatology

Open Access

Vulnerability and “minor” developmental disorders in late preterm infants

  • Giovanni Cioni1, 2 and
  • Francesca Tinelli1
Italian Journal of Pediatrics201440(Suppl 2):A21

DOI: 10.1186/1824-7288-40-S2-A21

Published: 9 October 2014

The National Institute of Child Health and Human Development panel reviewed the evidence of increased risk of infants with a gestational age of 34-36 weeks and, in 2006, changed the earlier definition of “near term” to “late preterm (LPT)”. LPT infants represent 70% of all the whole population of preterm but while it is known that they are at major risk of mortality and morbidity than term infants, less is known about their development outcome. Samra et al. [1] in 2011 published a review about this topic based on 817 articles but their conclusion was that, due to paucity and heterogeneity of the existing data, there was no clear characterization of the long-term risks. Since then some other interesting papers have been published, quite all in the direction that LPT children have some “minor” problems. In 2013, for example, Vohr B. [2] suggested that LPT infants are at increased risk of neurologic impairments, developmental disabilities, school failure, and behavior and psychiatric problems suggesting also that for each 1 week decrease in gestational age below 39 weeks, there are stepwise increases in adverse outcomes after adjusting for confounders. In 2014, Chan et al. [3] described the negative impact of LPT birth on academic outcomes at 7 years and Brumbaugh et al. [4] the negative impact on executive function at preschool age.

A possible explanation of these results is i) the demonstrated major vulnerability to the brain injury in the late preterm infant respect to the term infant, particularly involving the white matter [5] since that at 34 weeks the late preterm brain weights only 65% of the term brain and ii) the possible role of the extrauterine life compared with the intrauterine life during the last weeks of gestation.

Authors’ Affiliations

(1)
Department of Developmental Neuroscience, Stella Maris Scientific Institute
(2)
Department of Clinical and Experimental Medicine, University of Pisa

References

  1. Samra HA, McGrath JM, Wehbe M: An integrated review of developmental outcomes and late-preterm birth. J Obstet Gynecol Neonatal Nurs. 2011, 40 (4): 399-411. 10.1111/j.1552-6909.2011.01270.x.View ArticlePubMedGoogle Scholar
  2. Vohr B: Long-term outcomes of moderately preterm, late preterm, and early term infants. Clin Perinatol. 2013, 40 (4): 739-51. 10.1016/j.clp.2013.07.006.View ArticlePubMedGoogle Scholar
  3. Chan E, Quigley MA: School performance at age 7 years in late preterm and early term birth: a cohort study. Arch Dis Child Fetal Neonatal Ed. 2014, 10.1136/archdischild-2014-306124.Google Scholar
  4. Brumbaugh JE, Hodel AS, Thomas KM: The impact of late preterm birth on executive function at preschool age. Am J Perinatol. 2014, 31 (4): 305-14.PubMedGoogle Scholar
  5. Kinney HC: The near-term (late preterm) human brain and risk for periventricular leukomalacia: a review. Semin Perinatol. 2006, 30 (2): 81-8. 10.1053/j.semperi.2006.02.006.View ArticlePubMedGoogle Scholar

Copyright

© Cioni and Tinelli; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Advertisement