Skip to main content


  • Meeting abstract
  • Open Access

Bleeding management in pediatric patients

Italian Journal of Pediatrics201440 (Suppl 1) :A13

  • Published:


  • Factor VIIa
  • Major Bleeding
  • Compartment Syndrome
  • Desmopressin
  • Recombinant Factor VIIa

Bleeding has always been an alarming clinical symptom in all human societies, and physicians have had varying degrees of success in diagnosing and treating bleeding patients [1]. Because bleeding is part of the human experience, one the most challenging tasks for a physician is to discriminate between “normal” and “pathologic” bleeding. Hemorrhages or bleeds may occur in every tissue and organ. Every bleeding symptom may, however, vary greatly in terms of magnitude: for instance bleeds in the subcutaneous tissues may present as small pinpoint lesions (petechiae) or large bruises, and epistaxis may range from some blood-streaked mucus to a massive hemorrhage [2]. Minor bleeding is a broad category encompassing a wide variety of symptoms that are, however, severe enough to interfere with the patient’ everyday life. Major bleeding defines those episodes that may cause permanent damage to the patient or threaten his or her life. Major bleeding is defined as bleeding in a critical area (intracranial, intraspinal, intraocular, retroperitoneal, intra-articular or pericardial, or intramuscular with compartment syndrome) resulting in an hemoglobin fall > 2 g/dl or requiring transfusion [3]. Bleeding in a child can be a diagnostic challenge because of the wide range of causes, but making a specific diagnosis is clinically important in order to provide appropriate therapy. Bleeding disorders can be inherited or acquired, and include coagulation factor deficiencies or Von Willebrand diseases, platelet deficiencies and/or dysfunctions, blood vessels alterations [4]. The evaluation of a child presenting with bleeding should include a comprehensive medical and bleeding history, a complete family history, a detailed examination and selected laboratory tests. For immune thrombocytopenia, in newly diagnoses children, intravenous human immunoglobulin or corticosteroids can be used [5]. Individuals with platelet function defects should be managed by qualified specialist and platelet inhibitor medication should be avoid. First line drugs for patients with platelet dysfunction are: antifibrinolytics, desmopressin, platelet transfusions and recombinant factor VIIa [6, 7]. Bleeding events still occurs in patients with hemophilia despite prophylactic factor replacement. Adequate management depends not only upon the hemophilia subtype and site of bleeding, but also the episode severity, identifiable precipitants (e.g. trauma), the patients’ age and current place of residence, adequacy of venous access, presence of inhibitors, previous history of bleeding, and the time of onset in relation to prophylactic therapy. For all diseases other important initial considerations include the applicability of first aid measures (e.g ice, direct pressure, splinting) and appropriate analgesia [8].

Authors’ Affiliations

Dipartimento di Scienze Biomediche e Oncologia Umana, Clinica Pediatrica F. Vecchio, Università degli Studi di Bari “Aldo Moro”, Bari, Italy


  1. James P, Coller B: Phenotyping bleeding. Curr Opin Hematol. 2012, 19: 406-12. 10.1097/MOH.0b013e32835673ab.PubMed CentralView ArticlePubMedGoogle Scholar
  2. Rodeghiero F, Michel M, Gernsheimer T, Ruggeri M, Blanchette V, Bussel JB, Cines DB, Cooper N, Godeau B, Greinacher A, Imbach P, Khellaf M, Klaassen RJ, Kuhne T, Liebman H, Mazzucconi MG, Newland A, Pabinger I, Tosetto A, Stasi R: Standardization of bleeding assessment in immune thrombocytopenia: report from the International Working Group. Blood. 2013, 121: 2596-606. 10.1182/blood-2012-07-442392.View ArticlePubMedGoogle Scholar
  3. Schulman S, Kearon C: Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. J Thromb Haemost. 2005, 3: 692-4. 10.1111/j.1538-7836.2005.01204.x.View ArticlePubMedGoogle Scholar
  4. Revel-Vilk S: Clinical and laboratory assessment of the bleeding pediatric patient. Semin Thromb Hemost. 2011, 37: 756-62. 10.1055/s-0031-1297166.View ArticlePubMedGoogle Scholar
  5. Provan D, Stasi R, Newland AC, Blanchette VS: International consensus report on the investigations and management of primary immune thrombocytopenia. Blood. 2010, 115: 168-86. 10.1182/blood-2009-06-225565.View ArticlePubMedGoogle Scholar
  6. Almeida AM, Khair K, Hann I, Liesner R: The use of recombinant factor VIIa in children with inherited platelet function disorders. Br J Haematol. 2003, 121: 477-81. 10.1046/j.1365-2141.2003.04286.x.View ArticlePubMedGoogle Scholar
  7. Giordano P, Lassandro G, Tesse R, Longo S, Valente F, Cappiello AR, Coppola A: Innovative use of recombinant activated factor VII during physical rehabilitation in an Italian child with Glanzmann's thromboasthenia. Blood Transfus. 2013, 11: 143-7.PubMed CentralPubMedGoogle Scholar
  8. Giordano P, Franchini M, Lassandro G, Faienza MF, Valente R, Molinari AC: Issues in pediatric haemophilia care. Ital J Pediatr. 2013, 39: 24-10.1186/1824-7288-39-24.PubMed CentralView ArticlePubMedGoogle Scholar


© Giordano and Lassandro; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.