Volume 40 Supplement 1
Protein intake and nutritional programming: metabolic consequences
© Verduci et al; licensee BioMed Central Ltd. 2014
Published: 11 August 2014
According to recent epidemiological evidence, early protein intakes that exceeds metabolic requirements (>15% of energy) may increase weight gain during infancy and the risk of developing obesity in childhood: the so-called “early protein hypothesis” . A high protein intake, indeed, especially milk’s protein [2, 3], may enhance the secretion of insulin and insulin-like growth factor-I (IGF-I), associated with increased weight gain during the first 2 years of life, increase of adipocyte differentiation and adipogenic activity . In a large number of studies increased weight gain in infancy and early adiposity rebound have been associated with the development of later obesity . The presence of a positive strong association between early protein intake and increased weight gain in early childhood has been recently demonstrated in the European Childhood Obesity Project (CHOP): a multicenter, double-blind intervention trial involving both formula fed infants, randomly assigned to receive, during the first year of life, infant and follow-on formulas with different protein content (high or low), and breastfed infants as control group. This trial showed that both weight-for-length and BMI z-scores were significantly higher in the high protein (HP) compared with the low protein (LP) group at 12 and 24 months . Moreover the body composition analysis at 6 months of life showed that weight gain velocity from baseline to 6 months was significantly associated with fat mass, proving that higher early protein intakes may influence adiposity . Concerning metabolic data, HP group compared with LP group showed higher plasma concentrations of branched chain aminoacids, IGF-I and insulin at 6 months. Moreover, IGF-I concentrations have been associated with weight gain in the first 6 months of life . Additionally IGF-I could partly mediate protein-induced kidney growth in healthy children . This phenomenon was observed in the HP group: children at 6 months of life showed a significantly greater kidney volume compared with the LP group . However the long-term consequences of these results should be further evaluated.
Lastly it has been recently published that protein content of infant formulas may influence not only the growth pattern in the first two years, but also the risk of developing obesity at school-age, showing a 2.43 increased risk of obesity at 6 years of age in the HP vs LP group .
In conclusion these results suggest that early nutritional intervention programs are needed to avoid negative long-term consequences on health, especially to prevent “non-communicable diseases”in adult age.
- Riva E, Verduci E, Giovannini M, Agostoni C: Early protein intakes and adiposity: reloaded or downloaded. Acta Paediatr. 2004, 93: 725-726. 10.1111/j.1651-2227.2004.tb03007.x.View ArticlePubMedGoogle Scholar
- Hoppe C, Mølgaard C, Vaag A, Barkholt V, Michaelsen KF: High intakes of milk, but not meat, increase s-insulin and insulin resistance in 8-year-old boys. Eur J Clin Nutr. 2005, 59: 393-398. 10.1038/sj.ejcn.1602086.View ArticlePubMedGoogle Scholar
- Hoppe C, Mølgaard C, Juul A, Michaelsen KF: High intakes of skimmed milk, but not meat, increase serum IGF-I and IGFBP-3 in eight-year-old boys. Eur J Clin Nutr. 2004, 58: 1211-1216. 10.1038/sj.ejcn.1601948.View ArticlePubMedGoogle Scholar
- Koletzko B, von Kries R, Closa R, Escribano J, Scaglioni S, Giovannini M, Beyer J, Demmelmair H, Anton B, Gruszfeld D, Dobrzanska A, Sengier A, Langhendries JP, Rolland Cachera MF, Grote V: Can infant feeding choices modulate later obesity risk?. Am J Clin Nutr. 2009, 89: 1502S-1508S. 10.3945/ajcn.2009.27113D.View ArticlePubMedGoogle Scholar
- Koletzko B, von Kries R, Closa R, Escribano J, Scaglioni S, Giovannini M, Beyer J, Demmelmair H, Gruszfeld D, Dobrzanska A, Sengier A, Langhendries JP, Rolland Cachera MF, Grote V, European Childhood Obesity Trial Study Group: Lower protein in infant formula is associated with lower weight up to age 2 y: a randomized clinical trial. Am J Clin Nutr. 2009, 89: 1836-1845. 10.3945/ajcn.2008.27091.View ArticlePubMedGoogle Scholar
- Escribano J, Luque V, Ferre N, Mendez-Riera G, Koletzko B, Grote V, Demmelmair H, Bluck L, Wright A, Closa-Monasterolo R, European Childhood Obesity Trial Study Group: Effect of protein intake and weight gain velocity on body fat mass at 6 months of age: the EU Childhood Obesity Programme. Int J Obes. 2012, 36: 548-53. 10.1038/ijo.2011.276.View ArticleGoogle Scholar
- Socha P, Grote V, Gruszfeld D, Janas R, Demmelmair H, Closa-Monasterolo R, Subías JE, Scaglioni S, Verduci E, Dain E, Langhendries JP, Perrin E, Koletzko B, European Childhood Obesity Trial Study Group: Milk protein intake, the metabolic-endocrine response, and growth in infancy: data from a randomized clinical trial. Am J Clin Nutr. 2011, 94 (Suppl): 1776S-1784S.View ArticlePubMedGoogle Scholar
- Luque V, Escribano J, Grote V, Ferre N, Koletzko B, Gruszfeld D, Socha P, Langhendries JP, Goyens P, Closa-Monasterolo R, European Childhood Obesity Project: Does insulin-like growth factor-1 mediate protein-induced kidney growth in infants? A secondary analysis from a randomized controlled trial. Pediatr Res. 2013, 74: 223-229. 10.1038/pr.2013.87.View ArticlePubMedGoogle Scholar
- Escribano J, Luque V, Ferre N, Zaragoza-Jordana M, Grote V, Koletzko B, Gruszfeld D, Socha P, Dain E, Van Hees JN, Verduci E, Closa-Monasterolo R: Increased protein intake augments kidney volume and function in healthy infants. Kidney Int. 2011, 79: 783-90. 10.1038/ki.2010.499.View ArticlePubMedGoogle Scholar
- Weber M, Grote V, Closa-Monasterolo R, Escribano J, Langhendries JP, Dain E, Giovannini M, Verduci E, Gruszfeld D, Socha P, Koletzko B, European Childhood Obesity Trial Study Group: Lower protein content in infant formula reduces BMI and obesity risk at school age: follow-up of a randomized trial. Am J Clin Nutr. 2014, 99: 1041-1051. 10.3945/ajcn.113.064071.View ArticlePubMedGoogle Scholar
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