- Meeting abstract
- Open Access
Developmental haemostasis in moderate and late preterm infants
© Motta and Russo; licensee BioMed Central Ltd. 2014
- Published: 9 October 2014
- Reference Range
- Coagulation System
- Preterm Neonate
- Adult Level
- Late Preterm
The term “developmental haemostasis” was first coined by Maureen Andrews to describe the age-related physiological changes of the coagulation system during childhood. Given the age-dependent specificity of haemostasis, the evaluation and the interpretation of coagulation assays in newborns may present diagnostic difficulties and appropriate reference ranges for the diagnosis and management of coagulopathies in moderate and late preterm infants are needed.
Reference values for coagulation tests in healthy moderate and late preterm neonates (30 to 36 weeks of gestation) during the first 6 months of life.
Protein C (U/mL)
Protein S (U/mL)
Thromboelastography and the measurement of thrombin generation are methods that provide a global assessment of hemostasis. Recently, the use of these assays has been reported in neonates and the results suggest that these methods may offer advantages for the evaluation of developmental hemostasis. Thromboelastography, in particular, may be less sensitive to age-related changes of coagulation protein.[5, 6] However, the introduction of these methods into clinical practice of neonatal medicine should be based on larger studies confirming the predictive value of the assays.
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