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  • Meeting abstract
  • Open Access

Results after one year of rotavirus universal mass vaccination in Sicily

  • Francesco Vitale1Email author,
  • Fabio Tramuto1,
  • Emanuele Amodio1,
  • Vincenzo Restivo1 and
  • Claudio Costantino1
Italian Journal of Pediatrics201541(Suppl 2):A77

https://doi.org/10.1186/1824-7288-41-S2-A77

Published: 30 September 2015

Keywords

IntussusceptionGastroenteritisVaccination CoverageVaccination CampaignImmunization Schedule

Background

Rotavirus (RV) vaccination is the best strategy to prevent hospitalizations due to rotavirus gastroenteritis (RVGE) and is strongly recommended by international health authority [1]. The Sicilian Health Department introduced rotavirus universal mass vaccination (RUMV) into regional immunizations schedule in 2013 (mean vaccination coverage = 31%).

Intussusception is the invagination of one segment of the intestine within a more distal segment and even though the etiology is still unknown, in 1998, a relationship with a tetravalent rotavirus vaccine that was promptly withdrawn was suggested [2]. Post licensure surveillance studies have not confirmed previous findings and no increased risk of intussusception was found between vaccinated infants with both of the actually licensed rotavirus vaccines [3, 4].

Aim of this study is to analyze the trend of RVGE hospitalizations and contextually to monitor the trend of intussusception in Sicily from 2009 to 2013 after one year of RUMV.

Material and methods

Were collected data from hospital discharge records occurred from 1st January 2009 to 31st December 2013 in Sicily.

Cases of RVGE were defined as all hospitalizations with an ICD-9-CM diagnosis code of 008.61 on any position [5]. Furthermore, cases of intussusception were defined as all hospitalizations with an ICD-9-CM code of 560.0 on any discharge diagnoses.

Results

In 2013 the RVGE hospitalizations were 41% less in children aged 0-59 months and 43% less in children aged 0-23 months respect to the mean number of cases observed from 2009 to 2012 in Sicily (figure 1). Analyzing RVGE hospitalization rates per 100,000, was reported a significant reduction in both age classes in 2013 respect to mean incidence observed from 2009 to 2012 (0-59 months: from 395 to 242 cases/100,000; 0- 23 months from 609 to 364 cases/100,000) (figure 2).
Figure 1
Figure 1

Hospitalization cases for RVGE in children aged 0-59 and 0-23 months in Sicily from 2009 to 2013.

Figure 2
Figure 2

Hospitalization rates fro GERV observed before (2009-2012) and after (2013) RV vaccination introduction in Sicily (age classes 0-59 months and 0-23 months)

Finally, a significant increase in intussusception hospitalizations was not reported with respect to mean number of hospitalized children observed from 2009 to 2012 in age class 0 to 59 months. In particular, among children aged 0-23 months (directly exposed to vaccination in 2013) a slight reduction was observed with respect to mean number of cases reported in 2009-2012. (figure 3).
Figure 3
Figure 3

Hospitalization cases for intussusception in children aged 0-59 and 0-23 months in Sicily from 2009 to 2013

Conclusions

After one year of surveillance and despite reaching low vaccination coverage, our results demonstrated the high effectiveness of the RUMV strategy on reduction of RV circulation. Similar data on RV vaccination efficacy on early vaccination campaign was reported in Belgium [6].

Moreover, the steadiness of intussusception hospitalizations after introduction of RV vaccination allows us to confirm the security profile of the available vaccine.

Authors’ Affiliations

(1)
Department of Science for Health Promotion and Mother to Child Care “G. D'Alessandro”, University of Palermo, Palermo, Italy

References

  1. Cortese MM, Parashar UD: Centers for Disease Control and Prevention (CDC). Prevention of rotavirus gastroenteritis among infants and children: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2009, 58 (RR02): 1-25.PubMedGoogle Scholar
  2. Centers for Disease Control and Prevention (CDC): Withdrawal of rotavirus vaccine recommendation. MMWR Morb Mortal Wkly Rep. 1999, 48 (43): 1007-Google Scholar
  3. Murphy BR, Morens DM, Simonsen L, Chanock RM, La Montagne JR, Kapikian AZ: Reappraisal of the association of intussusception with the licensed live rotavirus vaccine challenges initial conclusions. J Infect Dis. 2003, 187 (8): 1301-1308. 10.1086/367895.PubMedView ArticleGoogle Scholar
  4. Belongia EA, Irving SA, Shui IM, Kulldorff M, Lewis E, Yin R, et al: Real-time surveillance to assess risk of intussusception and other adverse events after pentavalent, bovine-derived rotavirus vaccine. Pediatr Infect Dis J. 2010, 29 (1): 1-5. 10.1097/INF.0b013e3181af8605.PubMedView ArticleGoogle Scholar
  5. Costantino C, Amodio E, Vitale F: Impact on rotavirus gastro-enteritis hospitalisation during the first year of universal vaccination in Sicily. Paediatr Int Child Health. 2015, 2046905515Y0000000007-Google Scholar
  6. Raes M, Strens D, Vergison A, Verghote M, Standaert B: Reduction in pediatric rotavirus-related hospitalizations after universal rotavirus vaccination in Belgium. Pediatr Infect Dis J. 2011, 30 (1): e120-e125. 10.1097/INF.0b013e318214b811.PubMedView ArticleGoogle Scholar

Copyright

© Vitale et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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