Skip to main content

Long term treatment with omalizumab in adolescent with refractory solar urticaria



Solar urticaria represents an uncomfortable form of chronic inducible urticaria. First and second-line treatments are ineffective in some patients, leading to an impairment in their quality of life. Omalizumab represents a safe therapeutic option in case of refractory solar urticaria.

Case presentation

We update a case of a 21-year-old Caucasian girl affected by solar urticaria from the age of 14. Poor disease control was achieved with standard or high-dose of H1-antihistamines. Several omalizumab courses, including a 1-year-long course, were practiced resulting in clinical remission and significant improvement in patient’s quality of life.


Our experience confirms the effectiveness and safety of omalizumab for the management of refractory solar urticaria. Future studies are awaited in order to monitor long term effects and chronic doses of this treatment, particularly in patients who need concomitant therapy with antihistamines.


Solar urticaria (SU) represents a quite rare but uncomfortable form of chronic inducible urticaria. It is caused by sun-exposure and ultraviolet (UV) irradiation, UVB and more frequently UVA. Skin manifestations usually appear after few minutes of sunlight exposure. Because of its rarity, there are few data on the prevalence and incidence. SU usually manifests itself in the fourth decade of life and it occurs more commonly in women than men, regardless skin phototype and ethnicity [1]. First line treatment is based on second-generation H1-antihistamines, which can be increased up 2–4 fold the standard dosage to achieve clinical remission. However, standard therapy with antihistamines is ineffective in some patients; therefore, these patients require second and third-line therapeutic approaches (e.g. antileukotrienes, cyclosporine-A, biologics) along with absolute avoidance of sun exposure. The disease-related limitation of normal daily activity frequently leads to an impairment in quality of life of patients. Omalizumab, a recombinant humanized anti-IgE monoclonal antibody approved for the management of chronic spontaneous urticaria and severe asthma, has been recently demonstrated as a safe and effective therapeutic option in patients with inadequate response to standard therapies [2,3,4,5]. In Italy, omalizumab is approved for use in chronic spontaneous urticarial, but it is considered off-label for the management of chronic inducible urticaria, including SU [6].

Case presentation

We update a previously described case of a 21-year-old Caucasian girl suffering from SU from the age of 14 [7]. She was firstly treated with three H1-antihistamines at standard dose for a total of 8 months (cetirizine 10 mg/day, desloratadine 5 mg/day and hydroxyzine 25 mg/day) with unsatisfactory response to therapy. Treatment with H1-antihistamine at double dose (cetirizine 20 mg/day) associated to with H2-antihistamine at standard dose (ranitidine 150 mg/day) and antileukotriene (montelukast 10 mg/day) was also ineffective. During the first 2 years of disease, several 5-day courses of oral prednisone (25 mg daily) were prescribed as add-on therapy. However, the patient had a poor disease control. At the age of 16 she underwent a 9-month course of experimental therapy with omalizumab subcutaneously, with a starting dose of 375 mg every 2 weeks for 6 months which was progressively decreased to a monthly 150 mg maintenance dose up to suspension. Therapeutic response of the patient had been promptly obtained after the first administration and clinical improvement persisted when maintenance dose had been practiced. Clinical remission was confirmed by the negative results of photo-test for UVA and UVB which was performed at the end of omalizumab course and after 4 months from discontinuation of therapy (Fig. 1).

Fig. 1
figure 1

Evaluation of UAS7 values at each omalizumab course

During the subsequent 4 years, the patient underwent a total of 4 courses of subcutaneous omalizumab due to recurrent relapses of SU after sun exposure. Laboratory tests, including serum IgE levels, eosinophil count, inflammation markers and antinuclear antibodies, were performed at the beginning of each course. Disease activity was monitored by the Urticaria Activity Score over 7 days (UAS7). The first three therapeutic courses were practiced at the dose of 300 mg monthly for a total of 6 months. During treatment cutaneous symptoms faded to a complete remission, as demonstrated by the reduction of UAS7 score values (Fig. 1). Short treatment with second-generation antihistamines at standard dose was occasionally required during omalizumab course due to the appearance of mild cutaneous manifestations (rupatadin 10 mg/day or bilastine 20 mg/day) (Table 1).

Table 1 Occasional relapses of SU during the 4-year period of follow-up and required treatment

Symptoms appeared within just 1 month from the last administration of the third omalizumab therapeutic course. Thus, we decided to prescribe a prolonged course of treatment. The girl underwent omalizumab therapy at the previous tested effective dose of 300 mg monthly for 1 year continuously. The aim of this long lasting treatment was to achieve a more sustained response and persistent remission, according to scientific evidence [8, 9].

A complete clinical remission reconfirmed to be gained starting from the third dose and was associated with a sustained negativity of UAS7 values. At the 10th month of this treatment, standard dose of anti-histamines (rupatadin 10 mg/day for 7 days and following bilastine 20 mg/day for 7 days) was successfully practiced due to the appearance of two small flares resulting in itch and moderate sunlight-induced erythema. Photo-tests performed at the end of therapy resulted negative. No adverse effects were detected during all the omalizumab courses. Dermatology Life Quality Index (DLQI) questionnaire was completed by the patient to assess the impact of SU on quality of life prior to omalizumab treatment, at the end of both the first and last omalizumab courses. DLQI score was 24, 12 and 9, respectively, confirming a significant reduction of the emotional burden of the disease.

Discussion and conclusion

Omalizumab is a recombinant humanized monoclonal antibody that binds to the CHε3 region of IgE and, thus, avoids IgE from binding to FcεRI and FcεRII receptors on the surface of mast cells and basophils [10]. Omalizumab also prevents IgE from binding to FcεRI on dendritic cells and this could be related to a decreased release of inflammatory mediators with subsequent inhibitory effects on the allergen cascade [11]. Long-term therapy with omalizumab has been approved for the management of moderate to severe asthma and allergic rhinitis. It is also considered effective and safe in treating vernal keratoconjunctivitis and as an add-on maintenance treatment of nasal polyps [12,13,14]. The 2017 EAACI/GA2LEN/EDF/WAO international guidelines recommend the use of omalizumab as third–line of treatment for the management of CSU in adults and adolescents aged ≥12 years with inadequate response to H1-antihistamines [15]. Omalizumab use in patients younger than 12 years is still off-label for CSU despite emerging data suggesting safety and efficacy in this population [16].

Regarding chronic inducible urticaria, including SU, there are sparse reports on the use of omalizumab both in adult and pediatric patients [17, 18]. A recent systematic review, covering a total of 48 patients with antihistamine refractory SU, reported that treatment with omalizumab resulted in clinical improvement for 80% of patients, and 50% of them became symptom free. About 20% of patients failed to achieve any clinical response under a monthly dosage of 150–300 mg of omalizumab. Mild adverse events (i.e. gastrointestinal intolerance, periorbital edema, local reaction, and short-term asthenia) were recorded in only 11% of subjects [8]. However, most studies have short follow-up periods which are limited to a few months.

To the best of our knowledge, this is the first report describing a 4-year follow-up on omalizumab use to treat an adolescent patient with refractory SU. Our case confirms the rapid clinical efficacy and safety of 300 mg monthly dose. Noteworthy, a similar experience of long-term therapy with omalizumab plus low dose anti-histamines has been reported in a child with SU who was treated for 36 months resulting in clinical remission [8]. In recent years, research teams marked the importance to identify reliable biomarkers which are able to predict changes in disease activity as treatment response. Among these, baseline IgE levels appear to be the most intriguing factor. Some studies showed that among patients with chronic urticaria, non-responders to omalizumab had significantly lower baseline IgE levels than partial responders and complete responders [19, 20]. More specifically, low baseline serum IgE < 15.2 IU/mL would predict a lower likelihood of response to omalizumab [19]. Our case supports this finding since IgE values varied from 73.7 to 224.5 IU/ml before each therapeutic course, thus defining our patient as a full-responder.

Another relevant aspect that should be taken into account in SU patients is the psychological impact. Quality of life impairment is quite common among adults and children suffering from SU, especially during relapse times [21]. Can et al. have recently demonstrated that omalizumab not only provides symptom control for chronic urticaria but also improves patients’ psychological conditions, thereby making the disease less hard to manage [22]. Likewise, our patient reported a progressive improvement in quality of life as demonstrated by the reduction of DLQI questionnaire scores.

Finally, our experience regarding the last one-year course contributes to support information on efficacy, safety, and tolerability of a prolonged therapeutic regimen and strengthens the awareness that SU cases unresponsive to topical treatment and cyclosporin may need omalizumab [6, 8, 9]. However, unavoidable short exposure to UV, especially in sunny countries, facilitate the occurrence of recurrent relapses of SU after omalizumab discontinuation. In this context, the need of sustained omalizumab treatment at low dosage should be considered in the near future. Therefore, randomized controlled trials with long lasting follow-up are awaited to monitor the chronic doses of omalizumab and schedules for eligible patient suffering from solar urticaria unresponsive to conventional treatment.

Availability of data and materials

Not applicable.



Dermatology Life Quality Index


Solar Urticaria




Urticaria Activity Score


  1. Goetze S, Elsner P. Solar Urticaria. J Dtsch Dermatol Ges. 2015;13(12):1250–3.

    Article  PubMed  Google Scholar 

  2. Maurer M, Metz M, Brehler R, Hillen U, Jakob T, Mahler V, et al. Omalizumab treatment in patients with chronic inducible urticaria: a systematic review of published evidence. J All Clin Immunol. 2018;141(2):638–64.

    Article  CAS  Google Scholar 

  3. Caffarelli C, Paravati F, El Hachem M, Duse M, Bergamini M, Simeone G, et al. Management of chronic urticaria in children: a clinical guideline. Ital J Pediatr. 2019;45(1):101.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Crisafulli G, Caminiti L, Chiera F, Arasi S, Salzano G, Panasiti I, et al. Omalizumab in children with severe allergic disease: a case series. Ital J Pediatr. 2019;45(1):13.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Passanisi S, Arasi S, Caminiti L, Crisafulli G, Salzano G, Pajno GB. Omalizumab in children and adolescents with chronic spontaneous urticaria: case series and review of the literature. Dermatol Ther. 2020;33(4):e13489.

    Article  CAS  PubMed  Google Scholar 

  6. Damiani G, Diani M, Conic RRZ, Colli C, Ferrucci S, Martina E, et al. Omalizumab in chronic Urticaria: an Italian survey. Int Arch Allergy Immunol. 2019;178(1):45–9.

    Article  CAS  PubMed  Google Scholar 

  7. Arasi S, Crisafulli G, Caminiti L, Guarneri F, Aversa T, Porcaro F, et al. Treatment with omalizumab in a 16-year-old Caucasian girl with refractory solar urticaria. Pediatr Allergy Immunol. 2015;26(6):583–5.

    Article  PubMed  Google Scholar 

  8. Snast I, Kremer N, Lapidoth M, Enk CD, Tal Y, Rosman Y, et al. Omalizumab for the treatment of solar urticaria: case series and systematic review of the literature. J Allergy Clin Immunol Pract. 2018;4(4):1198–204.

    Article  Google Scholar 

  9. Silva PM, Costa AC, Mendes A, Barbosa MP. Long-term efficacy of omalizumab in seven patients with treatment-resistant chronic spontaneous urticaria. Allergol Immunopathol (Madr). 2015;43(2):168–73.

    Article  CAS  Google Scholar 

  10. Saini SS, MacGlashan DW, Sterbinsky SA, Togias A, Adelman DC, Lichtenstein LM, et al. Down-regulation of human basophil IgE and FC epsilon RI alpha surface densities and mediator release by anti-IgE-infusions is reversible in vitro and in vivo. J Immunol. 1999;162:5624–30.

    CAS  PubMed  Google Scholar 

  11. Holgate ST. New strategies with anti-IgE in allergic diseases. World Allergy Organ J. 2014;7(1):17.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Adachi M, Kozawa M, Yoshisue H, Milligan KL, Nagasaki M, Sasajima T, et al. Real-world safety and efficacy of omalizumab in patients with severe allergic asthma: a long-term post-marketing study in Japan. Respir Med. 2018;141:56–63.

    Article  PubMed  Google Scholar 

  13. Santamaría L, Sánchez J. Eficacia a largo plazo del omalizumab en pacientes con queratoconjuntivitis vernal resistente a tratamiento convencional [Long-term efficacy of omalizumab in patients with conventional treatment-resistant vernal keratoconjunctivitis]. Rev Alerg Mex. 2018;65(2):192–6.

    Article  PubMed  Google Scholar 

  14. Passanisi S, Caminiti L, Zirilli G, Lombardo F, Crisafulli G, Aversa T, et al. Biologics in food allergy: up-to-date. Expert Opin Biol Ther. 2021;21(9):1–9.

    Article  CAS  Google Scholar 

  15. Zuberbier T, Aberer W, Asero R, Abdul Latiff AH, Baker D, Ballmer-Weber B, et al. The EAACI/GA2LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy. 2018;73(7):1393–414.

    Article  CAS  PubMed  Google Scholar 

  16. Chang J, Cattelan L, Ben-Shoshan M, Le M, Netchiporouk E. Management of Pediatric Chronic Spontaneous Urticaria: a review of current evidence and guidelines. J Asthma Allergy. 2021;14:187–99.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Waibel KH, Reese DA, Hamilton RG, Devillez RL. Partial improvement of solar urticaria after omalizumab. J Allergy Clin Immunol. 2010;125(2):490–1.

    Article  CAS  PubMed  Google Scholar 

  18. Moncourier M, Assikar S, Matei I, Souyri N, Couture M, Rigot E, et al. Visible light-induced solar urticaria is improved by omalizumab. Photodermatol Photoimmunol Photomed. 2016;32(5-6):314–6.

    Article  CAS  PubMed  Google Scholar 

  19. Ertas R, Ozyurt K, Atasoy M, Hawro T, Maurer M. The clinical response to omalizumab in chronic spontaneous urticaria patients is linked to and predicted by IgE levels and their change. Allergy. 2018;73(3):705–12.

    Article  CAS  PubMed  Google Scholar 

  20. Straesser MD, Oliver E, Palacios T, Kyin T, Patrie J, Borish L. Serum IgE as an immunological marker to predict response to omalizumab treatment in symptomatic chronic urticaria. J Allergy Clin Immunol Pract. 2018;6:1386–1388.e1.

    Article  Google Scholar 

  21. Haylett AK, Koumaki D, Rhodes LE. Solar urticaria in 145 patients: assessment of action spectra and impact on quality of life in adults and children. Photodermatol Photoimmunol Photomed. 2018;34(4):262–8.

    Article  PubMed  Google Scholar 

  22. Can PK, Etikan P, Degirmentepe EN, Kocaturk E. Depression scores change significantly after omalizumab treatment in patients with chronic spontaneous urticaria. Asian Pac J Allergy Immunol. 2021.

Download references


Not applicable.


Not applicable.

Author information

Authors and Affiliations



MI and SP wrote the manuscript. LC and SA collected the clinical and laboratory data. GC he contributed to the discussion. GZ collected the bibliography. GBP reviewed the manuscript. Each author listed on the manuscript has seen and approved the submission of this version of the manuscript and takes full responsibility for the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Giovanni B. Pajno.

Ethics declarations

Ethics approval and consent to participate

Not applicable.

Consent for publication

Written informed consent was obtained from the patient’s parents for the publication of this case report.

Competing interests

The authors declare that they have no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Iannelli, M., Passanisi, S., Crisafulli, G. et al. Long term treatment with omalizumab in adolescent with refractory solar urticaria. Ital J Pediatr 47, 195 (2021).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: