Allergology and Immunology

This section considers studies regarding the epidemiology, pathology, prevention, and control of allergic and immunologic diseases in children and adolescents.

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  1. Case report

    Anaphylactic shock with methylprednisolone sodium succinate in a child with short bowel syndrome and cow’s milk allergy

    Medications with methyl-prednisolone sodium succinate containing lactose, which potentially contains traces of cow’s milk proteins (CMP), could cause allergic reactions or compromise treatment of acute allergi...

    Federica Porcaro, Maria Giovanna Paglietti, Antonella Diamanti, Francesca Petreschi, Alessandra Schiavino, Valentina Negro, Valentina Pecora, Alessandro Fiocchi and Renato Cutrera

    Italian Journal of Pediatrics 2017 43:104

    Published on: 17 November 2017

  2. Review

    Specific IgE and skin prick tests to diagnose allergy to fresh and baked cow’s milk according to age: a systematic review

    The diagnosis of IgE-mediated cow’s milk allergy is often based on anamnesis, and on specific IgE (sIgE) levels and/or Skin Prick Tests (SPT), which have both a good sensitivity but a low specificity, often ca...

    Barbara Cuomo, Giovanni Cosimo Indirli, Annamaria Bianchi, Stefania Arasi, Davide Caimmi, Arianna Dondi, Stefania La Grutta, Valentina Panetta, Maria Carmen Verga and Mauro Calvani

    Italian Journal of Pediatrics 2017 43:93

    Published on: 12 October 2017

  3. Research

    Efficacy and usability of a novel nebulizer targeting both upper and lower airways

    Upper and lower airways diseases share in part their pathogenic mechanisms and frequently occur simultaneously as “United Airway Disease.” Local treatment with nebulizers delivers anti-symptomatic drugs in eit...

    Daniela Posa, Antonio Pizzulli, Petra Wagner, Serena Perna, Stephanie Hofmaier, Paolo Maria Matricardi and Susanne Lau

    Italian Journal of Pediatrics 2017 43:89

    Published on: 29 September 2017

  4. Research

    Long-term treatment with low-dose medicine in chronic childhood eczema: a double-blind two-stage randomized control trial

    The efficacy of low-dose medicine (LDM) in childhood mild/moderate eczema is not known. We conducted a double-blind, two-stage, randomized, placebo-controlled clinical trial, lasting 23 months, to address this...

    R. Carello, L. Ricottini, V. Miranda, P. Panei, L. Rocchi, R. Arcieri and E. Galli

    Italian Journal of Pediatrics 2017 43:78

    Published on: 6 September 2017

  5. Review

    ANCA-associated vasculitis in childhood: recent advances

    Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides are rare systemic diseases that usually occur in adulthood. They comprise granulomatosis with polyangiitis (GPA, Wegener’s), microscopic poly...

    Marta Calatroni, Elena Oliva, Davide Gianfreda, Gina Gregorini, Marco Allinovi, Giuseppe A. Ramirez, Enrica P. Bozzolo, Sara Monti, Claudia Bracaglia, Giulia Marucci, Monica Bodria, Renato A. Sinico, Federico Pieruzzi, Gabriella Moroni, Serena Pastore, Giacomo Emmi…

    Italian Journal of Pediatrics 2017 43:46

    Published on: 5 May 2017

  6. Letter to the Editor

    The utility of the basophil activation test in the diagnosis of immediate amoxicillin or amoxicillin-clavulanate hypersensitivity in children and adults

    The basophil activation test (BAT), has been proposed as a possible assay for the diagnosis of immediate-type allergy to beta-lactams (BLs).

    Simona Barni, Francesca Mori, Claudia Valleriani, Giusi Mangone, Sergio Testi, Francesca Saretta, Lucrezia Sarti, Neri Pucci, Maurizio de Martino, Chiara Azzari and Elio Novembre

    Italian Journal of Pediatrics 2017 43:42

    Published on: 21 April 2017

  7. Research

    Bifidobacterium mixture (B longum BB536, B infantis M-63, B breve M-16V) treatment in children with seasonal allergic rhinitis and intermittent asthma

    Allergic rhinitis (AR) and allergic asthma are caused by an IgE-mediated inflammatory reaction. Probiotics may exert anti-inflammatory and immune-modulatory activity. Thus, this study aimed at investigating wh...

    Michele Miraglia Del Giudice, Cristiana Indolfi, Michele Capasso, Nunzia Maiello, Fabio Decimo and Giorgio Ciprandi

    Italian Journal of Pediatrics 2017 43:25

    Published on: 7 March 2017

  8. Review

    Clinical practice recommendations for allergen-specific immunotherapy in children: the Italian consensus report

    Allergen-specific immunotherapy (AIT) is currently recognized as a clinically effective treatment for allergic diseases, with a unique disease-modifying effect. AIT was introduced in clinical practice one cent...

    Giovanni Battista Pajno, Roberto Bernardini, Diego Peroni, Stefania Arasi, Alberto Martelli, Massimo Landi, Giovanni Passalacqua, Antonella Muraro, Stefania La Grutta, Alessandro Fiocchi, Luciana Indinnimeo, Carlo Caffarelli, Elisabetta Calamelli, Pasquale Comberiati and Marzia Duse

    Italian Journal of Pediatrics 2017 43:13

    Published on: 23 January 2017

  9. Research

    Vitamin D deficiency and its impact on asthma severity in asthmatic children

    Despite obtaining evidences on association between vitamin D and development of lung in fetus, little is known about vitamin D level and its impact on severity of asthma in children. The present study aimed to...

    Nasrin Esfandiar, Fariba Alaei, Shahrzad Fallah, Delara Babaie and Niloofar Sedghi

    Italian Journal of Pediatrics 2016 42:108

    Published on: 17 December 2016

  10. Case report

    Eosinophilic esophagitis after congenital diaphragmatic hernia

    Eosinophilic esophagitis (EoE) is an increasingly diagnosed disease, especially in the western world. Although its pathogenesis remains poorly understood, there is strong evidence that the eosinophilic inflamm...

    Amelia Licari, Riccardo Castagnoli and Gian Luigi Marseglia

    Italian Journal of Pediatrics 2016 42:96

    Published on: 8 November 2016

  11. Review

    Atopy and autoimmune thyroid diseases: melatonin can be useful?

    Recently, there has been growing interest in the relationship between allergic and autoimmune diseases. Allergy and autoimmunity can be considered two potential outcomes of dysregulated immunity and analysis o...

    Gabriella D’Angelo, Lucia Marseglia, Sara Manti, Laura Colavita, Caterina Cuppari, Pietro Impellizzeri, Salvatore Arena, Teresa Arrigo, Carmelo Salpietro and Eloisa Gitto

    Italian Journal of Pediatrics 2016 42:95

    Published on: 4 November 2016

  12. Research

    Kawasaki disease in Sicily: clinical description and markers of disease severity

    Kawasaki disease (KD) is an acute systemic vasculitis of small and middle size arteries; 15-25 % of untreated patients and 5 % of patients treated with intravenous immunoglobulin (IVIG) develop coronary artery...

    Maria Cristina Maggio, Giovanni Corsello, Eugenia Prinzi and Rolando Cimaz

    Italian Journal of Pediatrics 2016 42:92

    Published on: 2 November 2016

  13. Case report

    Brain damage resembling acute necrotizing encephalopathy as a specific manifestation of haemophagocytic lymphohistiocytosis - induced by hypersensitivity

    Both haemophagocytic lymphohistiocytosis and acute necrotizing encephalopathy are life-threatening condition. It presents major diagnostic difficulties, since it may have a diversity in clinical picture and wi...

    Dongling Dai, Feiqiu Wen, Sixi Liu and Shaoming Zhou

    Italian Journal of Pediatrics 2016 42:79

    Published on: 31 August 2016

  14. Research

    The B-cell compartment in antibody-deficient infants and young children – developing common variable immunodeficiency or transient immune maturation?

    Hypogammaglobulinemia in early childhood is a common feature characterized by distinct intrinsic and extrinsic factors leading to disturbed peripheral blood lymphocyte homeostasis. Detailed flow cytometric imm...

    Aleksandra Szczawinska-Poplonyk, Katarzyna Tapolska-Jozwiak and Husam Samara

    Italian Journal of Pediatrics 2016 42:71

    Published on: 26 July 2016

  15. Research

    Shared genetic variants between serum levels of high-density lipoprotein cholesterol and wheezing in a cohort of children from Cyprus

    In a cohort of children in Cyprus, we recently reported low levels of high density lipoprotein cholesterol (HDL-C) to be associated with asthma. We examined whether genetic polymorphisms that were previously l...

    Panayiotis K. Yiallouros, Panayiotis Kouis, Ourania Kolokotroni, Sonia Youhanna, Savvas C. Savva, Kleanthi Dima, Aikaterini Zerva, Danielle Platt, Nicos Middleton and Pierre Zalloua

    Italian Journal of Pediatrics 2016 42:67

    Published on: 13 July 2016

  16. Case report

    Pulmonary manifestation of immunoglobulin G4-related disease in a 7-year-old immunodeficient boy with Epstein-Barr virus infection: a case report

    Immunoglobulin G4-related disease (IgG4-RD) is a multiorgan fibroinflammatory condition with lymphoplasmacytic infiltrates containing abundant IgG4-positive plasma cells. The immunopathogenesis of the disease ...

    Aleksandra Szczawinska-Poplonyk, Irena Wojsyk-Banaszak, Katarzyna Jonczyk-Potoczna and Anna Breborowicz

    Italian Journal of Pediatrics 2016 42:58

    Published on: 8 June 2016

  17. Commentary

    Beyond the “Choosing wisely”: a possible attempt

    Since the fundamental principles of the medical profession were clearly defined in a physician charter in 2002, special considerations have been expressed about the adequate distribution of health care resourc...

    Roberto Bernardini, Giampaolo Ricci, Francesca Cipriani, Flavio Civitelli, Luciana Indinnimeo, Domenico Minasi, Luigi Terracciano and Marzia Duse

    Italian Journal of Pediatrics 2016 42:55

    Published on: 28 May 2016

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