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  1. Planning optimal fluid and inotrope-vasopressor-inodilator therapy is essential in critically ill children. Pulse index Contour Cardiac Output (PiCCO) monitoring is an invasive, hemodynamic monitor that provid...

    Authors: Nagehan Aslan, Dincer Yildizdas, Ozden Ozgur Horoz, Yasemin Coban, Fadli Demir, Sevcan Erdem and Yasar Sertdemir

    Citation: Italian Journal of Pediatrics 2020 46:47

    Content type: Research

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  2. Exposure to hypothermia is somehow unavoidable when a baby comes to life. This is the reason why any possible effort should be made by every caregiver involved during birth, from labour to transfer into the ma...

    Authors: Daniele Merazzi, Ilia Bresesti, Paolo Tagliabue, Maria Grazia Valsecchi, Paola De Lorenzo and Gianluca Lista

    Citation: Italian Journal of Pediatrics 2020 46:46

    Content type: Research

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  3. Fetal programming during in utero life defines the set point of physiological and metabolic responses that lead into adulthood; events happening in “the first 1,000 days” (from conception to 2-years of age), p...

    Authors: Benedetta Raspini, Debora Porri, Rachele De Giuseppe, Marcello Chieppa, Marina Liso, Rosa Maria Cerbo, Elisa Civardi, Francesca Garofoli, Maria Cristina Monti, Mirco Vacca, Maria De Angelis and Hellas Cena

    Citation: Italian Journal of Pediatrics 2020 46:45

    Content type: Research

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  4. Harlequin Ichthyosis is the most severe variant of congenital autosomal recessive ichthyosis, associated with severe morbidity and potentially lethal in early life. At birth, patients present thick and plaque-...

    Authors: Cinzia Auriti, Roberta Rotunno, Andrea Diociaiuti, Silvia Magni Manzoni, Andrea Uva, Iliana Bersani, Alessandra Santisi, Andrea Dotta and May El Hachem

    Citation: Italian Journal of Pediatrics 2020 46:44

    Content type: Case report

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  5. Preterm infants are at risk for structural disruption of brain connectivity due to perinatal complications encountered during the fetal and neonatal periods. This study aimed to investigate the development of ...

    Authors: Jong Ho Cha, Yong-Ho Choi, Jong-Min Lee, Joo Young Lee, Hyun-Kyung Park, Jinsup Kim, Il-Kewon Kim and Hyun Ju Lee

    Citation: Italian Journal of Pediatrics 2020 46:43

    Content type: Research

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  6. Recurrent respiratory infections (RRIs) are defined by the presence of at least one of the following criteria: (i) > 6 annual respiratory infections (RIs); (ii) > 1 monthly RIs involving the upper airways from...

    Authors: Sara Manti, Giuseppe Fabio Parisi, Maria Papale, Amelia Licari, Carmelo Salpietro, Michele Miraglia del Giudice, Gian Luigi Marseglia and Salvatore Leonardi

    Citation: Italian Journal of Pediatrics 2020 46:42

    Content type: Research

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  7. Off- label drug use refers to the use of medicines outside of their marketing authorization with respect to dose, dosage form, route of administration, indication or age. Off-label/unlicensed drug use signific...

    Authors: Meles Tekie Gidey, Yohannes Gebrehaweria Gebretsadkan, Afewerki Gebremeskel Tsadik, Abraham Gebrezgabiher Welie and Brhane Teklebrhan Assefa

    Citation: Italian Journal of Pediatrics 2020 46:41

    Content type: Research

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  8. Vitamin B12 (cobalamin, cbl) deficiency in children is rare and may occurs in exclusively breast fed infants of mothers on vegetarian or vegan diet with lack of appropriate supplementation. The clinical manifesta...

    Authors: Cezary Dubaj, Katarzyna Czyż and Wanda Furmaga-Jabłońska

    Citation: Italian Journal of Pediatrics 2020 46:40

    Content type: Case report

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  9. Pubertal timing is known to be influenced by interactions among various genetic, nutritional, environmental and socio-economic factors, although the ultimate mechanisms underlying the increase in pulsatile GnR...

    Authors: Sara Pagani, Valeria Calcaterra, Gloria Acquafredda, Chiara Montalbano, Elena Bozzola, Pietro Ferrara, Manuela Gasparri, Alberto Villani and Mauro Bozzola

    Citation: Italian Journal of Pediatrics 2020 46:39

    Content type: Research

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  10. Chronic cough is a common symptom in children and protracted bacterial bronchitis (PBB) is one of the causes of chronic cough. However, the understanding of this disease remains limited. The present study aims...

    Authors: Xiao-bo Zhang, Xiao Wu and Guang-min Nong

    Citation: Italian Journal of Pediatrics 2020 46:38

    Content type: Research

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  11. In the last years, ‘omics’ technologies, and especially metabolomics, emerged as expanding scientific disciplines and promising technologies in the characterization of several pathophysiological processes.

    Authors: Flaminia Bardanzellu and Vassilios Fanos

    Citation: Italian Journal of Pediatrics 2020 46:37

    Content type: Review

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  12. Seizures in individuals affected by tuberous sclerosis complex (TSC) commonly develop in the first year of life, are often preceded by a progressive deterioration of the electroencephalogram (EEG), and likely ...

    Authors: M. N. Savini, A. Mingarelli, A. Peron, F. La Briola, F. Cervi, R. M. Alfano, M. P. Canevini and A. Vignoli

    Citation: Italian Journal of Pediatrics 2020 46:36

    Content type: Research

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  13. The prevalence of children with neurological impairment (NI) presenting feeding difficulties and gastrointestinal symptoms is rising. The most recent guidelines recommend early nutritional assessment and inter...

    Authors: Valeria Dipasquale, Frederic Gottrand, Peter B. Sullivan and Claudio Romano

    Citation: Italian Journal of Pediatrics 2020 46:35

    Content type: Review

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  14. Healthcare-associated infections (HAIs) occur frequently in intensive care units (NICUs). The aim of this study was to analyze the results of surveillance of HAIs in a III level NICU in Naples, Italy during 20...

    Authors: Marina Silvia Scamardo, Pasquale Dolce, Eliana Pia Esposito, Francesco Raimondi, Maria Triassi and Raffaele Zarrilli

    Citation: Italian Journal of Pediatrics 2020 46:34

    Content type: Research

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  15. The management of chronic diseases, particularly in children, requires an integrated physical and psychological approach to both sick children and their family. This is the case of Cystic Fibrosis (CF), a comp...

    Authors: Grazia Isabella Continisio, Nicola Serra, Assunta Guillari, Maria Teresa Civitella, Angela Sepe, Silvio Simeone, Gianpaolo Gargiulo, Silvia Toscano, Maria Rosaria Esposito, Valeria Raia and Teresa Rea

    Citation: Italian Journal of Pediatrics 2020 46:33

    Content type: Research

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  16. Children with Down syndrome (DS) show a high susceptibility to recurrent infections (RI), caused by immune defects and abnormalities of the airways. Our goal was to investigate the effects of Pidotimod on RI p...

    Authors: Diletta Valentini, Chiara Di Camillo, Nadia Mirante, Valentina Marcellini, Rita Carsetti and Alberto Villani

    Citation: Italian Journal of Pediatrics 2020 46:31

    Content type: Research

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  17. The original article contains a misspelling of co-author, Christine Bodemer’s name which is presented correctly in this Correction article.

    Authors: May El Hachem, Damiano Abeni, Andrea Diociaiuti, Roberta Rotunno, Francesco Gesualdo, Giovanna Zambruno and Christine Bodemer

    Citation: Italian Journal of Pediatrics 2020 46:30

    Content type: Correction

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    The original article was published in Italian Journal of Pediatrics 2019 45:26

  18. Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis in the pediatric population worldwide and an important cause of death in developing countries. It has been demonstrated that the bala...

    Authors: Isabella Tarissi De Jacobis, Rosa Vona, Elisabetta Straface, Lucrezia Gambardella, Giulia Ceglie, Francesca de Gennaro, Ilenia Pontini, Anna Chiara Vittucci, Alessandra Carè, Camilla Cittadini, Alberto Villani and Donatella Pietraforte

    Citation: Italian Journal of Pediatrics 2020 46:29

    Content type: Research

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  19. Child vaccination is an instrument for saving millions of lives. Only one in twenty children has access to childhood vaccination in hard to reach areas in developing countries. Although studies have been done ...

    Authors: Ayal Debie and Ayenew Molla Lakew

    Citation: Italian Journal of Pediatrics 2020 46:28

    Content type: Research

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  20. CDKL5-related disorders (CDD) is an epileptic encephalopathy resulted of gene mutations of CDKL5. This study aimed to explore the development process of CDD and to expand its mutation spectrum.

    Authors: Yumei Yan, Dake He, Jing Wu, Ruolin Hou, Kun Sun and Ling Li

    Citation: Italian Journal of Pediatrics 2020 46:27

    Content type: Research

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  21. The survival of preterm babies has increased worldwide, but the risk of neuro-developmental disabilities remains high, which is of concern to both the public and professionals. The early identification of chil...

    Authors: Licia Lugli, Marisa Pugliese, Carlotta Plessi, Alberto Berardi, Isotta Guidotti, Gina Ancora, Sara Grandi, Giancarlo Gargano, Silvia Braibanti, Fabrizio Sandri, Silvia Soffritti, Elisa Ballardini, Vittoria Arena, Marcello Stella, Serafina Perrone, Sabrina Moretti…

    Citation: Italian Journal of Pediatrics 2020 46:26

    Content type: Research

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  22. Aplasia cutis congenita (ACC), classified in nine groups, is likely to be underreported, since milder isolated lesions in wellbeing newborns could often be undetected, and solitary lesions in the context of po...

    Authors: Ingrid Anne Mandy Schierz, Mario Giuffrè, Antonello Del Vecchio, Vincenzo Antona, Giovanni Corsello and Ettore Piro

    Citation: Italian Journal of Pediatrics 2020 46:25

    Content type: Research

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  23. Patients affected by acute central nervous system (ACNS) infectionsmay present different complications, including neuropsychological disorders. Nevertheless, psychopathological impairment has been rarely measu...

    Authors: Elena Bozzola, Giulia Spina, Paola Bergonzini, Mauro Bozzola, Massimiliano Raponi and Alberto Villani

    Citation: Italian Journal of Pediatrics 2020 46:23

    Content type: Research

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  24. The optimal management of PDA in very low birth weight (VLBW) infants is still controversial. Aim of our study was to investigate the management of PDA in the Italian neonatal intensive care units (NICU).

    Authors: Benjamim Ficial, Iuri Corsini, Stefano Fiocchi, Federico Schena, Irma Capolupo, Rosa Maria Cerbo, Manuela Condò, Daniela Doni, Simona La Placa, Salvatore Porzio, Katia Rossi, Sabrina Salvadori and Marilena Savoia

    Citation: Italian Journal of Pediatrics 2020 46:22

    Content type: Research

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  25. Neonatal acidaemia at birth can increase neonatal morbidity and mortality and it is predictive of neonatal asphyxia. The umbilical blood gas analysis is a valid tool for the evaluation of neonatal acidaemia. H...

    Authors: Giuseppe De Bernardo, Rita De Santis, Maurizio Giordano, Desiree Sordino, Giuseppe Buonocore and Serafina Perrone

    Citation: Italian Journal of Pediatrics 2020 46:20

    Content type: Research

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  26. The pathophysiological etiologies related with the development of Autism Spectrum Disorders (ASD) remain controversial. Different authors have studied neurotoxins such as mercury (Hg) and their relationship wi...

    Authors: Fernando Gil-Hernández, Antonio R. Gómez-Fernández, María Josede la Torre-Aguilar, Juan L. Pérez-Navero, Katherine Flores-Rojas, Pilar Martín-Borreguero and Mercedes Gil-Campos

    Citation: Italian Journal of Pediatrics 2020 46:19

    Content type: Research

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  27. The upper airways (UA) should be considered as a functional unit. Current functional anatomy divides URT in three, mutually dependent, “junction boxes”: i) the ostio-meatal complex (OMC), ii) the spheno-ethmoi...

    Authors: Attilio Varricchio, Ignazio La Mantia, Francesco Paolo Brunese and Giorgio Ciprandi

    Citation: Italian Journal of Pediatrics 2020 46:18

    Content type: Commentary

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  28. The risk factors for multi-drug resistant infection (MDRI) in the pediatric intensive care unit (PICU) remain unclear. It’s necessary to evaluate the epidemiological characteristics and risk factors for MDRI i...

    Authors: Zaihua Wang and Zhongfang Xia

    Citation: Italian Journal of Pediatrics 2020 46:17

    Content type: Research

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  29. Initial establishment of the human gut microbiota is generally believed to occur immediately following birth, involving key gut commensals such as bifidobacteria that are acquired from the mother. The subseque...

    Authors: Francesca Turroni, Christian Milani, Sabrina Duranti, Gabriele Andrea Lugli, Sergio Bernasconi, Abelardo Margolles, Francesco Di Pierro, Douwe van Sinderen and Marco Ventura

    Citation: Italian Journal of Pediatrics 2020 46:16

    Content type: Review

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  30. We report a case of a 4-year-old girl with acute dacryocystitis complicated with giant lacrimal abscess who underwent open dacryocystectomy as resolutive surgery.

    Authors: Maria Di Cicco, Elisabetta Maria Bellino, Andrea Marabotti, Laura Luti, Diego G. Peroni and Giampiero I. Baroncelli

    Citation: Italian Journal of Pediatrics 2020 46:15

    Content type: Case report

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  31. As more and more diagnostic and interventional options are becoming available for use in pediatric patients, techniques of procedural sedation analgesia (PSA) are being administered in considerably growing num...

    Authors: Harald Sauer, Marie Lobenhofer and Hashim Abdul-Khaliq

    Citation: Italian Journal of Pediatrics 2020 46:14

    Content type: Research

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  32. In recent years, medical training has significantly increased the use of simulation for teaching and evaluation. The retraining of medical personnel in Italy is entrusted to the program of Continuous Education...

    Authors: Alice Covelli, Serena Bardelli, Rosa T. Scaramuzzo, Emilio Sigali, Massimiliano Ciantelli, Marta Del Pistoia, Alessia Longo, Selene Tognarelli, Arianna Menciassi and Armando Cuttano

    Citation: Italian Journal of Pediatrics 2020 46:13

    Content type: Research

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  33. Children with chronic respiratory failure and/or sleep disordered breathing due to a broad range of diseases may require long-term ventilation to be managed at home. Advances in the use of long-term non-invasi...

    Authors: Martino Pavone, Elisabetta Verrillo, Alessandro Onofri, Serena Caggiano, Maria Beatrice Chiarini Testa and Renato Cutrera

    Citation: Italian Journal of Pediatrics 2020 46:12

    Content type: Research

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  34. Given the inadequate overall awareness of the main disease features and treatment modalities of pruritus in pediatric patients with atopic dermatitis, a multidisciplinary Italian expert group met with the majo...

    Authors: May El Hachem, Giuseppe Di Mauro, Roberta Rotunno, Simona Giancristoforo, Cristiana De Ranieri, Carla Maria Carlevaris, Maria Carmen Verga and Iride Dello Iacono

    Citation: Italian Journal of Pediatrics 2020 46:11

    Content type: Review

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  35. Preterm birth (PTB) can be caused by different factors. The factors can be classified into different categories: socio demographic, obstetric, reproductive health, medical, behavioral and nutritional related. ...

    Authors: Tariku Laelago, Tadele Yohannes and Gulima Tsige

    Citation: Italian Journal of Pediatrics 2020 46:10

    Content type: Review

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  36. The aims of the study were to determine the effects of electronic exposure on behaviors of preschoolers, which could provide scientific grounds to the control of digital screen time and usage of electronics.

    Authors: Guodong Xie, Qianye Deng, Jing Cao and Qing Chang

    Citation: Italian Journal of Pediatrics 2020 46:9

    Content type: Research

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  37. In Italy live about 8.7% immigrants, which contribute to more than 15% of all deliveries taking place in Italy. We aimed to investigate whether newborns from high migratory pressure countries (HMPC) mothers ha...

    Authors: Mario De Curtis, Leonardo Villani and Arianna Polo

    Citation: Italian Journal of Pediatrics 2020 46:8

    Content type: Letter to the Editor

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  38. The efficacy of dopamine versus epinephrine for pediatric or neonatal septic shock remains controversial. We conduct a meta-analysis to explore the influence of dopamine versus epinephrine on shock reversal fo...

    Authors: Lingling Wen and Liangyin Xu

    Citation: Italian Journal of Pediatrics 2020 46:6

    Content type: Research

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  39. Drug Hypersensitivity Reactions (DHRs) are considered adverse effects of medications that resemble allergy symptoms. The reported positive clinical history of pediatric drug reactions is about 10%, however, af...

    Authors: A. Piccorossi, G. Liccioli, S. Barni, L. Sarti, M. Giovannini, A. Verrotti, E. Novembre and F. Mori

    Citation: Italian Journal of Pediatrics 2020 46:5

    Content type: Research

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  40. The goal of this literature review is to compare current studies regarding the accuracy of different serum markers in differentiating viral from bacterial pneumonia in the pediatric population with what is emp...

    Authors: Jithin Thomas, Aiste Pociute, Rimantas Kevalas, Mantas Malinauskas and Lina Jankauskaite

    Citation: Italian Journal of Pediatrics 2020 46:4

    Content type: Review

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  41. Congenital cytomegalovirus (cCMV) infection is the most frequent non-genetic cause of sensorineural hearing-loss (SNHL) (i.e., hearing loss due to a cochlear and/or auditory nerve damage). It is widely accepte...

    Authors: Fabio Natale, Mario De Curtis, Bianca Bizzarri, Maria Patrizia Orlando, Massimo Ralli, Giuseppina Liuzzi, Barbara Caravale, Francesco Franco, Aurelia Gaeta, Antonella Giancotti, Francesca Yoshie Russo and Rosaria Turchetta

    Citation: Italian Journal of Pediatrics 2020 46:3

    Content type: Research

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  42. Anemia in newborn babies causes asymptomatic to an acute life-threatening event. If untreated, it leads to a delay in brain maturation, tissue hypoxia, and stunted growth. In Sub-Saharan Africa, its burden ran...

    Authors: Tegenaw Tiruneh, Elias Shiferaw and Bamlaku Enawgaw

    Citation: Italian Journal of Pediatrics 2020 46:1

    Content type: Research

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  43. Virtual Reality (VR) as a tool for pain reduction is the research topic of several clinical trial for Randomized Controlled Trials despite its wide use in the daily clinical practice for non- pharmacological r...

    Authors: Anna Maria Iannicelli, Daniele Vito, Concetta Anna Dodaro, Pasquale De Matteo, Rita Nocerino, Angela Sepe and Valeria Raia

    Citation: Italian Journal of Pediatrics 2019 45:171

    Content type: Review

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  44. Radiation therapy represents an important approach in the therapeutic management of children and adolescents with malignant tumors and its application with modern techniques – including Proton Beam Therapy (PB...

    Authors: Angela Sardaro, Roberta Carbonara, Maria Fonte Petruzzelli, Barbara Turi, Marco Moschetta, Arnaldo Scardapane and Amato Antonio Stabile Ianora

    Citation: Italian Journal of Pediatrics 2019 45:170

    Content type: Review

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