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  1. Hepatoblastoma (HB) is the most common malignant liver tumor in children. Abnormal activation of the Wnt/β-catenin signaling pathway plays an important role in the formation and development of HB. Genes in HB ...

    Authors: Gang Shen, Hongyu Shen, Jing Zhang, Qingtao Yan and Huixian Liu

    Citation: Italian Journal of Pediatrics 2020 46:113

    Content type: Review

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  2. Listeria monocytogenes is a Gram-positive bacteria transmitted to human by animal stools, contaminated water and food.

    Authors: Giacomo Brisca, Alberto La Valle, Claudia Campanello, Mattia Pacetti, Mariasavina Severino, Giuseppe Losurdo, Antonella Palmieri, Isabella Buffoni and Salvatore Renna

    Citation: Italian Journal of Pediatrics 2020 46:111

    Content type: Case report

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  3. Myositis ossificans (MO) is a heterotopic bone formation in soft tissues, usually caused by traumas or neuropathies. Although the aetiology remains unclear, MO is supposed to be an osteoblast metaplasia with a...

    Authors: Luisa Cortellazzo Wiel, Matteo Trevisan, Flora Maria Murru, Marco Rabusin and Egidio Barbi

    Citation: Italian Journal of Pediatrics 2020 46:110

    Content type: Case report

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  4. Allergic transfusion reactions (ATRs) are immunological reactions after transfusion. Interleukin-1 (IL-1) is a critical regulator for human diseases. We performed this study to investigate the association of t...

    Authors: Wenjing Hu, Li Feng, Meng Li, Ting Li, Yudong Dai and Xiaowei Wang

    Citation: Italian Journal of Pediatrics 2020 46:109

    Content type: Research

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  5. Silver-Russell Syndrome (SRS) is a genetic disorder characterized by intrauterine and postnatal growth restriction and normal head circumference with consequent relative macrocephaly. Addictional findings are ...

    Authors: Francesca Mercadante, Martina Busè, Emanuela Salzano, Tiziana Fragapane, Daniela Palazzo, Michela Malacarne and Maria Piccione

    Citation: Italian Journal of Pediatrics 2020 46:108

    Content type: Case report

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  6. Pregnancy may represent a time of exceptional vulnerability to intimate partner violence because of changes in women’s conditions. Despite the fact that intimate partner violence during pregnancy confers consi...

    Authors: Kahsay Zenebe Gebreslasie, Solomon Weldemariam, Gelawdiyos Gebre and Mihret-Ab Mehari

    Citation: Italian Journal of Pediatrics 2020 46:107

    Content type: Research

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  7. Despite to PFAPA syndrome is considered a benign and self-limited condition in childhood its impact on patients and families can be remarkable in many cases. Currently, the therapeutic options for managing are...

    Authors: Sara Manti, Federica Filosco, Giuseppe Fabio Parisi, Giuseppe Germano Finocchiaro, Maria Papale, Andrea Giugno, Patrizia Barone and Salvatore Leonardi

    Citation: Italian Journal of Pediatrics 2020 46:106

    Content type: Research

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  8. Digital health technologies carry the great potential of assisting physicians in making well-informed diagnostic and therapeutic decisions. In allergy care, electronic clinical diaries have been recently used ...

    Authors: Salvatore Tripodi, Andrea Giannone, Ifigenia Sfika, Simone Pelosi, Stephanie Dramburg, Annamaria Bianchi, Antonio Pizzulli, Jakob Florack, Valeria Villella, Ekaterina Potapova and Paolo Maria Matricardi

    Citation: Italian Journal of Pediatrics 2020 46:105

    Content type: Review

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  9. During the last decade several paediatric studies have been published with different possible indications for probiotics, leading to a global increase of probiotics’ market. Nevertheless, different study desig...

    Authors: Massimo Martinelli, Giuseppe Banderali, Marisa Bobbio, Elisa Civardi, Alberto Chiara, Sofia D’Elios, Andrea Lo Vecchio, Mattia Olivero, Diego Peroni, Claudio Romano, Mauro Stronati, Renato Turra, Irene Viola, Annamaria Staiano and Alberto Villani

    Citation: Italian Journal of Pediatrics 2020 46:104

    Content type: Review

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    The Correction to this article has been published in Italian Journal of Pediatrics 2020 46:116

  10. Pediatric obesity is one of the most relevant health issues of the last century. Obesity-related short and long-term consequences are responsible of a large amount of economic cost. In addition, the different ...

    Authors: Roberta Romanelli, Nicola Cecchi, Maria Grazia Carbone, Michele Dinardo, Giuseppina Gaudino, Emanuele Miraglia del Giudice and Giuseppina Rosaria Umano

    Citation: Italian Journal of Pediatrics 2020 46:103

    Content type: Review

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  11. Dehydrated hereditary stomatocytosis (DHS) or hereditary xerocytosis is a rare, autosomal dominant hemolytic anemia characterized by macrocytosis, presence of stomatocytes and dehydration of red blood cells (R...

    Authors: Daniele Zama, Giulia Giulietti, Edoardo Muratore, Immacolata Andolfo, Roberta Russo, Achille Iolascon and Andrea Pession

    Citation: Italian Journal of Pediatrics 2020 46:102

    Content type: Case report

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  12. In the pediatric setting, management of pain in the emergency department – and even in common care – is a challenging exercise, due to the complexity of the pediatric patient, poor specific training of many ph...

    Authors: Franca Benini, Ilaria Corsini, Emanuele Castagno, Davide Silvagni, Annunziata Lucarelli, Luca Giacomelli, Angela Amigoni, Gina Ancora, Marinella Astuto, Fabio Borrometi, Rosa Maria Casilli, Elena Chiappini, Renato Cutrera, Arianna De Matteis, Giuseppe di Mauro, Anna Musolino…

    Citation: Italian Journal of Pediatrics 2020 46:101

    Content type: Letter to the Editor

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  13. Preterm infants have an increased risk of cognitive and behavioral deficits and cerebral palsy compared to term born babies. Especially before 32 weeks of gestation, infants may require respiratory support, bu...

    Authors: Laura Cannavò, Immacolata Rulli, Raffaele Falsaperla, Giovanni Corsello and Eloisa Gitto

    Citation: Italian Journal of Pediatrics 2020 46:100

    Content type: Review

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  14. The Sudden Unexpected Infant Death Syndrome (SUID) is one of the leading causes of mortality in the first year of life. The aim of this work was the retrospective evaluation of the incidence of SUID and the ef...

    Authors: Raffaele Piumelli, Niccolò Nassi, Annamaria Buccoliero, Rossella Occhini, Vincenzo Nardini, Paolo Toti, Cristina Salvatori, Marta Peruzzi and Cinzia Arzilli

    Citation: Italian Journal of Pediatrics 2020 46:99

    Content type: Research

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  15. Syndromic congenital heart disease accounts for 30% of cases and can be determined by genetic, environmental or multifactorial causes. In many cases the etiology remains uncertain. Many known genes are respons...

    Authors: Silvia Amodeo, Giuseppe Vitrano, Melania Guardino, Giuseppe Paci, Fulvio Corselli, Vincenzo Antona, Giuseppe Barrano, Monia Magliozzi, Antonio Novelli, Renato Venezia and Giovanni Corsello

    Citation: Italian Journal of Pediatrics 2020 46:98

    Content type: Case report

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  16. Complications of acute sinusitis affecting multiple sites are very uncommon, and generally develop for a delayed diagnosis of the primary infection, with possible severe and life-threatening evolution. Patient...

    Authors: Lorenzo Solimeno, Sara Torretta, Paola Marchisio, Elisabetta Iofrida, Samantha Bosis, Claudia Tagliabue, Giada Maria Di Pietro, Lorenzo Pignataro and Claudio Guastella

    Citation: Italian Journal of Pediatrics 2020 46:97

    Content type: Case report

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  17. Tracheal agenesis (TA) is a rare disorder usually diagnosed prenatally when a congenital high airway obstruction syndrome (CHAOS) is identified. We present a case of unexpected TA in a neonate without prenatal...

    Authors: Alessandro Perri, Maria Letizia Patti, Annamaria Sbordone, Giovanni Vento and Rita Luciano

    Citation: Italian Journal of Pediatrics 2020 46:96

    Content type: Case report

    Published on:

    The Correction to this article has been published in Italian Journal of Pediatrics 2020 46:115

  18. MED13L-related intellectual disability is a new syndrome that is characterized by intellectual disability (ID), motor developmental delay, speech impairment, hypotonia and facial dysmorphism. Both the MED13L h...

    Authors: Zhi Yi, Ying Zhang, Zhenfeng Song, Hong Pan, Chengqing Yang, Fei Li, Jiao Xue and Zhenghai Qu

    Citation: Italian Journal of Pediatrics 2020 46:95

    Content type: Case report

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  19. Using available official data we found 248 epidemics curves caused worldwide by the 2019-nCoV in the period December 2019–March 31st 2020. The analysis of this material allowed two main observations: 1) it is ...

    Authors: Roberto Ronchetti and Pietro Massimiliano Bianco

    Citation: Italian Journal of Pediatrics 2020 46:94

    Content type: Letter to the Editor

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  20. Allergic rhinitis (AR) and adenoidal hypertrophy (AH) are the most frequent causative disorders of nasal obstruction in children, leading to recurrent respiratory infections. Both nasal cavities are colonized ...

    Authors: Giulia Brindisi, Anna Maria Zicari, Laura Schiavi, Alessandra Gori, Maria Pia Conte, Massimiliano Marazzato, Giovanna De Castro, Lucia Leonardi and Marzia Duse

    Citation: Italian Journal of Pediatrics 2020 46:93

    Content type: Research

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  21. Childhood epilepsies are a heterogeneous group of conditions differing in diagnostic criteria, management, and outcome. Late-infantile neuronal ceroid lipofuscinosis type 2 (CLN2) is a neurodegenerative condit...

    Authors: Elisabetta Amadori, Marcello Scala, Giulia Sofia Cereda, Maria Stella Vari, Francesca Marchese, Veronica Di Pisa, Maria Margherita Mancardi, Thea Giacomini, Laura Siri, Fabiana Vercellino, Domenico Serino, Alessandro Orsini, Alice Bonuccelli, Irene Bagnasco, Amanda Papa, Carlo Minetti…

    Citation: Italian Journal of Pediatrics 2020 46:92

    Content type: Research

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  22. Under nutrition and overweight typically occur during nutritional transition periods in developing countries including Egypt. Short stature and anemia are public health concern due to its strong link with maln...

    Authors: Ali M. El-Shafie, Zeinab A. Kasemy, Zein A. Omar, Safa H. Alkalash, Amal A. Salama, Kerollos S. Mahrous, Shaimaa M. Hewedy, Nessreen M. Kotb, Heba S. Abd El-Hady, Eman S. Eladawy, Mohamed A. Zeid, Manar E. Abd El Hamid, Emad H. Hemeda, Mohamed A. El-shafie, Esraa A. El-Meligy and Wael A. Bahbah

    Citation: Italian Journal of Pediatrics 2020 46:91

    Content type: Research

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  23. Linezolid is a synthetic antibiotic which is active against most Gram-positive bacteria, especially on Staphylococcus aureus. Its administration can be required when the infection is due to staphylococcus strains...

    Authors: Cinzia Auriti, Fiammetta Piersigilli, Iliana Bersani, Sara Cairoli, Paolina Giuseppina Amante, Daniela Longo and Bianca Maria Goffredo

    Citation: Italian Journal of Pediatrics 2020 46:90

    Content type: Case report

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  24. We highlight the main developments that have been published during the first semester of the last year in the Italian Journal of Pediatrics. We have carefully chosen information from numerous exciting progress...

    Authors: Carlo Caffarelli, Francesca Santamaria, Virginia Mirra, Ermanno Bacchini, Angelica Santoro, Sergio Bernasconi and Giovanni Corsello

    Citation: Italian Journal of Pediatrics 2020 46:89

    Content type: Review

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  25. Cerebral palsy (CP) is a non-progressive disorder of movement and posture due to a static insult to the brain. In CP, the depth of investigation is guided by the patients’ medical history and their clinical ex...

    Authors: Liqin Hu, Xiaoqin Xin, Shaobin Lin, Min Luo, Junkun Chen, Hongsheng Qiu, Li Ma and Jungao Huang

    Citation: Italian Journal of Pediatrics 2020 46:88

    Content type: Case report

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  26. Since the outbreak of COVID-19 pandemic, the number of cases registered worldwide has risen to over 3 million. While COVID-19 per se does not seem to represent a significant threat to the pediatric population,...

    Authors: Benedetta Ciacchini, Francesco Tonioli, Cinzia Marciano, Maria Grazia Faticato, Elena Borali, Alessio Pini Prato and Enrico Felici

    Citation: Italian Journal of Pediatrics 2020 46:87

    Content type: Letter to the Editor

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  27. Furosemide is approved in full term neonates to treat edema associated with congestive heart failure, cirrhosis and renal diseases. It is often administered off-label in premature neonates, to treat respirator...

    Authors: Valeria Anna Manfredini, Chiara Cerini, Antonio Clavenna, Andrea Dotta, Maria Letizia Caccamo, Alex Staffler, Luca Massenzi and Rossano Massimo Rezzonico

    Citation: Italian Journal of Pediatrics 2020 46:86

    Content type: Research

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  28. Disruptive behavior can have lifetime consequences for youth. Prevention, early identification and treatment of disruptive behavior can improve outcomes for these youth. The purpose of the present study was to...

    Authors: Marzieh Araban, Ali Montazeri, L. A. R. Stein, Mahmood Karimy and Ali Asghar Haeri Mehrizi

    Citation: Italian Journal of Pediatrics 2020 46:85

    Content type: Research

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  29. The COVID-19 pandemic has surprised the entire population. The world has had to face an unprecedented pandemic. Only, Spanish flu had similar disastrous consequences. As a result, drastic measures (lockdown) h...

    Authors: Fabio Cardinale, Giorgio Ciprandi, Salvatore Barberi, Roberto Bernardini, Carlo Caffarelli, Mauro Calvani, Giovanni Cavagni, Elena Galli, Domenico Minasi, Michele Miraglia del Giudice, Viviana Moschese, Elio Novembre, Francesco Paravati, Diego G. Peroni, Maria Angela Tosca, Giovanni Traina…

    Citation: Italian Journal of Pediatrics 2020 46:84

    Content type: Review

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  30. Data about acute poisoning in Italian pediatric patients are obsolete or absent. This study would partially fill this exiting gap and compare the scene with others around the world.

    Authors: Giovanni N. Berta, Federica Di Scipio, Francesca M. Bosetti, Barbara Mognetti, Federica Romano, Maria E. Carere, Anna C. Del Giudice, Emanuele Castagno, Claudia Bondone and Antonio F. Urbino

    Citation: Italian Journal of Pediatrics 2020 46:83

    Content type: Research

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  31. In internationally adopted children disorders of linear growth, puberty development, thyroid function, and bone metabolism are frequently reported. It is important that these children receive careful auxologic...

    Authors: Stefano Stagi, Valeria Papacciuoli, Djibril Boiro, Chiara Maggioli, Niane Ndeye Ndambao, Stefania Losi, Elena Chiappini, Sonia Toni and Ousmane Ndiaye

    Citation: Italian Journal of Pediatrics 2020 46:82

    Content type: Review

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  32. Hereditary multiple osteochondromas (HMO) is a genetic condition characterized by the presence of multiple osteochondromas, usually at the lateral side of the most active growth plate of a long bone. These les...

    Authors: Andrea Trombetta, Vanessa Migliarino, Flavio Faletra, Egidio Barbi and Gianluca Tornese

    Citation: Italian Journal of Pediatrics 2020 46:81

    Content type: Case report

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  33. An epidemiological transition is interesting Sub-Saharan Africa increasing the burden of non-communicable diseases most of which are of surgical interest. Local resources are far from meeting needs and, consid...

    Authors: Pierluigi Lelli Chiesa, Osman T. M. Osman, Antonio Aloi, Mariagrazia Andriani, Alberto Benigni, Claudio Catucci, Paolo Giambelli, Gabriele Lisi, Faisal M. Nugud, Paola Presutti, Viviana Prussiani, Vincenzo Racalbuto, Fabio Rossi, Giuliana Santoponte, Bruno Turchetta, Diaa Eldinn Yaseen Mohammed Salman…

    Citation: Italian Journal of Pediatrics 2020 46:80

    Content type: Research

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  34. The epidemic of coronavirus disease 2019 (COVID-19) broke out in Wuhan, China, in December 2019 and rapidly spread across the world. In order to counter this epidemic, several countries put in place different ...

    Authors: Maria Pia Fantini, Chiara Reno, Giovanni Battista Biserni, Elena Savoia and Marcello Lanari

    Citation: Italian Journal of Pediatrics 2020 46:79

    Content type: Letter to the Editor

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  35. Clubfoot is the most frequent congenital malformation of the foot, affecting more than 1–2 subjects per 1.000 newborns. Without appropriate treatment, a child with congenital clubfoot will never be able to wal...

    Authors: Daniela Dibello, Valentina Di Carlo, Giulia Colin, Egidio Barbi and Anna M. C. Galimberti

    Citation: Italian Journal of Pediatrics 2020 46:78

    Content type: Commentary

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  36. Vitamin A administration may decrease any stage of retinopathy of prematurity (ROP) in preterm infants. To evaluate whether vitamin A oral supplementation could be preventive in ROP incidence and severity in V...

    Authors: Francesca Garofoli, Donatella Barillà, Micol Angelini, Iolanda Mazzucchelli, Annalisa De Silvestri, Rosanna Guagliano, Lidia Decembrino and Chryssoula Tzialla

    Citation: Italian Journal of Pediatrics 2020 46:77

    Content type: Letter to the Editor

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  37. Studies investigating the prevalence of hypertension and its correlation with anthropometric indices among adolescents are still scarce compared to those conducted in adults of greater than 40 years. So far, n...

    Authors: Godfrey Katamba, David Collins Agaba, Richard Migisha, Agnes Namaganda, Rosemary Namayanja and Eleanor Turyakira

    Citation: Italian Journal of Pediatrics 2020 46:76

    Content type: Research

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  38. Varicella may complicate with cerebellitis in previously healthy children, requiring hospitalization. Aim of our study was to define whether children who experienced varicella cerebellitis have a normal immune...

    Authors: Elena Bozzola, Rita Carsetti, Eva Piano Mortari, Marco Masci, Giulia Spina and Alberto Villani

    Citation: Italian Journal of Pediatrics 2020 46:75

    Content type: Research

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  39. Schinzel-Giedion syndrome (SGS) is a multiple malformation syndrome mainly characterized by severe intellectual disability, distinctive facial features, and multiple congenital anomalies, including skeletal ab...

    Authors: Maria Pia Leone, Pietro Palumbo, Orazio Palumbo, Ester Di Muro, Massimiliano Chetta, Nicola Laforgia, Nicoletta Resta, Alessandro Stella, Stefano Castellana, Tommaso Mazza, Marco Castori, Massimo Carella and Nenad Bukvic

    Citation: Italian Journal of Pediatrics 2020 46:74

    Content type: Case report

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  40. The rate of twinning continues to increase due to the combined effect of a rise in parental age and increased use of assisted reproductive technology. The risk of congenital anomalies in twins is higher than i...

    Authors: Ettore Piro, Ingrid Anne Mandy Schierz, Gregorio Serra, Giuseppe Puccio, Mario Giuffrè and Giovanni Corsello

    Citation: Italian Journal of Pediatrics 2020 46:73

    Content type: Research

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  41. Aim of this retrospective study was to describe clinical characteristics, diagnostic work-up, management and follow-up of newborns with neural tube defects (NTDs), admitted to the Mother and Child Department o...

    Authors: Ettore Piro, Gregorio Serra, Ingrid Anne Mandy Schierz, Mario Giuffrè and Giovanni Corsello

    Citation: Italian Journal of Pediatrics 2020 46:72

    Content type: Research

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  42. Delayed umbilical cord clamping is associated with greater haemoglobin concentration and iron storage between 3 and 6 months of life and with less need of blood transfusion and lower incidence of neonatal hypo...

    Authors: Giuseppe De Bernardo, Maurizio Giordano, Rita De Santis, Paola Castelli, Desiree Sordino, Daniele Trevisanuto, Giuseppe Buonocore and Serafina Perrone

    Citation: Italian Journal of Pediatrics 2020 46:71

    Content type: Research

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  43. Human Immunodeficiency Virus (HIV) infection and low birth weight (LBW) continue to be significant public health concerns in many low-income countries including Ethiopia. Yet the effect of maternal HIV infecti...

    Authors: Andualem Zenebe, Betelhem Eshetu and Samson Gebremedhin

    Citation: Italian Journal of Pediatrics 2020 46:70

    Content type: Research

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  44. Effective prevention and control strategies are mandatory to prevent SARS-CoV-2 infection.

    Authors: Elisabetta Bignamini, Salvatore Cazzato, Renato Cutrera, Giuliana Ferrante, Stefania La Grutta, Amelia Licari, Enrico Lombardi, Fabio Midulla, Giorgio Piacentini, Massimo Pifferi, Francesca Santamaria, Giancarlo Tancredi and Attilio Turchetta

    Citation: Italian Journal of Pediatrics 2020 46:68

    Content type: Letter to the Editor

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  45. A prompt diagnosis of HIE remains a challenge clinically. This study aimed to identify potential biomarkers of neonatal hypoxic-ischemic encephalopathy (HIE) via a novel proteomic approach, the isobaric tags f...

    Authors: Yuanyuan Zhu, Yajing Yun, Meifang Jin, Gen Li, Hong Li, Po Miao, Xin Ding, Xing Feng, Lixiao Xu and Bin Sun

    Citation: Italian Journal of Pediatrics 2020 46:67

    Content type: Research

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  46. Colorectal polyps are reported in 6,1% of paediatric colonoscopies and in 12% of those performed for lower gastrointestinal bleeding. Although colonoscopy is widely used in paediatric patients, it requires bow...

    Authors: Giovanni Di Nardo, Francesco Esposito, Chiara Ziparo, Caterina Strisciuglio, Francesca Vassallo, Marco Di Serafino, Maria Pia Villa, Pasquale Parisi, Melania Evangelisti, Claudia Pacchiarotti and Vito Domenico Corleto

    Citation: Italian Journal of Pediatrics 2020 46:66

    Content type: Research

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  47. As the quality and quantity of patient-centered care may be perceived differently by recipients and independent observers, assessment of humanization of pediatric care remains an elusive issue. Herein we aim t...

    Authors: C. Mandato, M. A. Siano, A. G. E. De Anseris, M. Tripodi, G. Massa, R. De Rosa, M. Buffoli, A. Lamanna, P. Siani and P. Vajro

    Citation: Italian Journal of Pediatrics 2020 46:65

    Content type: Research

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  48. Coarctation of the aorta (CoA), presenting with local stenosis of the aorta is involved in many cardiovascular processes. However, there has been little research on the mechanism of coarctation of the aorta.

    Authors: Siyu Ma, Junqiang Zheng, Yang Xu, Zhaocong Yang, Yu Zhu, Xiaoqi Su and Xuming Mo

    Citation: Italian Journal of Pediatrics 2020 46:63

    Content type: Research

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  49. Due to novel coronavirus infection emergency, restricting measures have been imposed in Italy. As well as adults, also children are limited in their daily routine.

    Authors: Alberto Villani, Elena Bozzola, Paolo Siani and Giovanni Corsello

    Citation: Italian Journal of Pediatrics 2020 46:62

    Content type: Commentary

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