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  1. Jaffe-Campanacci syndrome is characterized by multiple non-ossifying fibromas, café-au-lait macules and giant cell granulomas of the jaw. Even if the association between all these peculiar features and neurofi...

    Authors: Silvia Vannelli, Raffaele Buganza, Federica Runfola, Ilaria Mussinatto, Antonio Andreacchio and Luisa de Sanctis

    Citation: Italian Journal of Pediatrics 2020 46:58

    Content type: Case report

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  2. In Italy, as in many European countries, Pediatric Emergency Medicine is not formally recognized as a pediatric subspecialty, hindering nation-wide adoption of standards of care, especially in the field of pro...

    Authors: Idanna Sforzi, Silvia Bressan, Claudia Saffirio, Salvatore De Masi, Leonardo Bussolin, Liviana Da Dalt, Fabio De Iaco, Itai Shavit, Baruch Krauss and Egidio Barbi

    Citation: Italian Journal of Pediatrics 2020 46:57

    Content type: Research

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  3. Recently, an outbreak of viral pneumonitis in Wuhan, Hubei, China successively spread as a global pandemia, led to the identification of a novel betacoronavirus species, the 2019 novel coronavirus, successivel...

    Authors: Domenico Umberto De Rose, Fiammetta Piersigilli, Maria Paola Ronchetti, Alessandra Santisi, Iliana Bersani, Andrea Dotta, Olivier Danhaive and Cinzia Auriti

    Citation: Italian Journal of Pediatrics 2020 46:56

    Content type: Review

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  4. Beckwith-Wiedemann syndrome (BWS) is a genetic overgrowth disorder with variable clinical features and cancer predisposition. In this study, we aim to characterize the clinical features and molecular defects o...

    Authors: Ruixue Wang, Yongmei Xiao, Dan Li, Hui Hu, Xiaolu Li, Ting Ge, Ronghua Yu, Yizhong Wang and Ting Zhang

    Citation: Italian Journal of Pediatrics 2020 46:55

    Content type: Research

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  5. Although disseminated intravascular coagulation (DIC) is a critical disease, there is few gold standard interventions in neonatal medicine. The aim of this study is to reveal factors affecting neonatal DIC at ...

    Authors: Hayato Go, Hitoshi Ohto, Kenneth E. Nollet, Nozomi Kashiwabara, Kei Ogasawara, Mina Chishiki, Shun Hiruta, Ichiri Sakuma, Yukihiko Kawasaki and Mitsuaki Hosoya

    Citation: Italian Journal of Pediatrics 2020 46:54

    Content type: Research

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  6. An early diagnosis of CHARGE syndrome is challenging, especially for the primary care physicians who often take care of neonates with multiple congenital anomalies. Here we report eight cases of CHARGE syndrom...

    Authors: Maria Francesca Bedeschi, Beatrice Letizia Crippa, Lorenzo Colombo, Martina Buscemi, Cesare Rossi, Roberta Villa, Silvana Gangi, Odoardo Picciolini, Claudia Cinnante, Viola Giulia Carlina Fergnani, Paola Francesca Ajmone, Elisa Scola, Fabio Triulzi and Fabio Mosca

    Citation: Italian Journal of Pediatrics 2020 46:53

    Content type: Research

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  7. Feeding intolerance in premature infants is one of the main causes of their long-term hospitalization in NICUs. Massage therapy is a cost-effective intervention that has a positive impact on the health of infa...

    Authors: Leila Seiiedi-Biarag and Mojgan Mirghafourvand

    Citation: Italian Journal of Pediatrics 2020 46:52

    Content type: Review

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  8. Mayer-Rokitansky-Küster-Hauser (MRKHS) syndrome refers to congenital hypoplasia/aplasia of the uterus, the cervix and the upper 2/3 of the vagina, in females with normal ovaries and fallopian tubes, secondary ...

    Authors: Giuliana Morabito, Alessandro Daidone, Flora Murru, Marianna Iaquinto, Elena Faleschini, Egidio Barbi and Giorgio Cozzi

    Citation: Italian Journal of Pediatrics 2020 46:51

    Content type: Case report

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  9. Atopic eczema (AE) is the most common inflammatory skin disease in infancy and its prevalence is rising worldwide. It has a wide social impact on the affected children and their families’ lives. AE can have a ...

    Authors: Mattia Giovannini, Davide Geat, Gabriele Barlocco, Riccardo Pertile, Francesca Mori, Cesare Filippeschi, Elio Novembre, Mario Cristofolini and Ermanno Baldo

    Citation: Italian Journal of Pediatrics 2020 46:50

    Content type: Letter to the Editor

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  10. Ascites can develop as a consequence of a number of diseases in childhood. Despite chronic liver disease is the most common cause, several conditions can lead to ascites also in the absence of liver dysfunctio...

    Authors: Alessandro Rossi, Velia Melone, Rossella Turco, Luigi Camera, Eugenia Bruzzese, Erasmo Miele, Annamaria Staiano, Alfredo Guarino and Andrea Lo Vecchio

    Citation: Italian Journal of Pediatrics 2020 46:49

    Content type: Case report

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  11. Massive gastrointestinal bleeding in children is uncommon. Dieulafoy lesion is an uncommon disease which may lead to massive and repeated upper gastrointestinal hemorrhage. We report two cases of gastric Dieul...

    Authors: Giovanni Di Nardo, Gianluca Esposito, Angela Mauro, Letizia Zenzeri, Gian Paolo Ciccarelli, Andrea Catzola, Alessandro Rossi and Vito Domenico Corleto

    Citation: Italian Journal of Pediatrics 2020 46:48

    Content type: Case report

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  12. Planning optimal fluid and inotrope-vasopressor-inodilator therapy is essential in critically ill children. Pulse index Contour Cardiac Output (PiCCO) monitoring is an invasive, hemodynamic monitor that provid...

    Authors: Nagehan Aslan, Dincer Yildizdas, Ozden Ozgur Horoz, Yasemin Coban, Fadli Demir, Sevcan Erdem and Yasar Sertdemir

    Citation: Italian Journal of Pediatrics 2020 46:47

    Content type: Research

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  13. Exposure to hypothermia is somehow unavoidable when a baby comes to life. This is the reason why any possible effort should be made by every caregiver involved during birth, from labour to transfer into the ma...

    Authors: Daniele Merazzi, Ilia Bresesti, Paolo Tagliabue, Maria Grazia Valsecchi, Paola De Lorenzo and Gianluca Lista

    Citation: Italian Journal of Pediatrics 2020 46:46

    Content type: Research

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  14. Fetal programming during in utero life defines the set point of physiological and metabolic responses that lead into adulthood; events happening in “the first 1,000 days” (from conception to 2-years of age), p...

    Authors: Benedetta Raspini, Debora Porri, Rachele De Giuseppe, Marcello Chieppa, Marina Liso, Rosa Maria Cerbo, Elisa Civardi, Francesca Garofoli, Maria Cristina Monti, Mirco Vacca, Maria De Angelis and Hellas Cena

    Citation: Italian Journal of Pediatrics 2020 46:45

    Content type: Research

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  15. Harlequin Ichthyosis is the most severe variant of congenital autosomal recessive ichthyosis, associated with severe morbidity and potentially lethal in early life. At birth, patients present thick and plaque-...

    Authors: Cinzia Auriti, Roberta Rotunno, Andrea Diociaiuti, Silvia Magni Manzoni, Andrea Uva, Iliana Bersani, Alessandra Santisi, Andrea Dotta and May El Hachem

    Citation: Italian Journal of Pediatrics 2020 46:44

    Content type: Case report

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  16. Preterm infants are at risk for structural disruption of brain connectivity due to perinatal complications encountered during the fetal and neonatal periods. This study aimed to investigate the development of ...

    Authors: Jong Ho Cha, Yong-Ho Choi, Jong-Min Lee, Joo Young Lee, Hyun-Kyung Park, Jinsup Kim, Il-Kewon Kim and Hyun Ju Lee

    Citation: Italian Journal of Pediatrics 2020 46:43

    Content type: Research

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  17. Recurrent respiratory infections (RRIs) are defined by the presence of at least one of the following criteria: (i) > 6 annual respiratory infections (RIs); (ii) > 1 monthly RIs involving the upper airways from...

    Authors: Sara Manti, Giuseppe Fabio Parisi, Maria Papale, Amelia Licari, Carmelo Salpietro, Michele Miraglia del Giudice, Gian Luigi Marseglia and Salvatore Leonardi

    Citation: Italian Journal of Pediatrics 2020 46:42

    Content type: Research

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  18. Off- label drug use refers to the use of medicines outside of their marketing authorization with respect to dose, dosage form, route of administration, indication or age. Off-label/unlicensed drug use signific...

    Authors: Meles Tekie Gidey, Yohannes Gebrehaweria Gebretsadkan, Afewerki Gebremeskel Tsadik, Abraham Gebrezgabiher Welie and Brhane Teklebrhan Assefa

    Citation: Italian Journal of Pediatrics 2020 46:41

    Content type: Research

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  19. Vitamin B12 (cobalamin, cbl) deficiency in children is rare and may occurs in exclusively breast fed infants of mothers on vegetarian or vegan diet with lack of appropriate supplementation. The clinical manifesta...

    Authors: Cezary Dubaj, Katarzyna Czyż and Wanda Furmaga-Jabłońska

    Citation: Italian Journal of Pediatrics 2020 46:40

    Content type: Case report

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  20. Pubertal timing is known to be influenced by interactions among various genetic, nutritional, environmental and socio-economic factors, although the ultimate mechanisms underlying the increase in pulsatile GnR...

    Authors: Sara Pagani, Valeria Calcaterra, Gloria Acquafredda, Chiara Montalbano, Elena Bozzola, Pietro Ferrara, Manuela Gasparri, Alberto Villani and Mauro Bozzola

    Citation: Italian Journal of Pediatrics 2020 46:39

    Content type: Research

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  21. Chronic cough is a common symptom in children and protracted bacterial bronchitis (PBB) is one of the causes of chronic cough. However, the understanding of this disease remains limited. The present study aims...

    Authors: Xiao-bo Zhang, Xiao Wu and Guang-min Nong

    Citation: Italian Journal of Pediatrics 2020 46:38

    Content type: Research

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  22. In the last years, ‘omics’ technologies, and especially metabolomics, emerged as expanding scientific disciplines and promising technologies in the characterization of several pathophysiological processes.

    Authors: Flaminia Bardanzellu and Vassilios Fanos

    Citation: Italian Journal of Pediatrics 2020 46:37

    Content type: Review

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  23. Seizures in individuals affected by tuberous sclerosis complex (TSC) commonly develop in the first year of life, are often preceded by a progressive deterioration of the electroencephalogram (EEG), and likely ...

    Authors: M. N. Savini, A. Mingarelli, A. Peron, F. La Briola, F. Cervi, R. M. Alfano, M. P. Canevini and A. Vignoli

    Citation: Italian Journal of Pediatrics 2020 46:36

    Content type: Research

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  24. The prevalence of children with neurological impairment (NI) presenting feeding difficulties and gastrointestinal symptoms is rising. The most recent guidelines recommend early nutritional assessment and inter...

    Authors: Valeria Dipasquale, Frederic Gottrand, Peter B. Sullivan and Claudio Romano

    Citation: Italian Journal of Pediatrics 2020 46:35

    Content type: Review

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  25. Healthcare-associated infections (HAIs) occur frequently in intensive care units (NICUs). The aim of this study was to analyze the results of surveillance of HAIs in a III level NICU in Naples, Italy during 20...

    Authors: Marina Silvia Scamardo, Pasquale Dolce, Eliana Pia Esposito, Francesco Raimondi, Maria Triassi and Raffaele Zarrilli

    Citation: Italian Journal of Pediatrics 2020 46:34

    Content type: Research

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  26. The management of chronic diseases, particularly in children, requires an integrated physical and psychological approach to both sick children and their family. This is the case of Cystic Fibrosis (CF), a comp...

    Authors: Grazia Isabella Continisio, Nicola Serra, Assunta Guillari, Maria Teresa Civitella, Angela Sepe, Silvio Simeone, Gianpaolo Gargiulo, Silvia Toscano, Maria Rosaria Esposito, Valeria Raia and Teresa Rea

    Citation: Italian Journal of Pediatrics 2020 46:33

    Content type: Research

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  27. Children with Down syndrome (DS) show a high susceptibility to recurrent infections (RI), caused by immune defects and abnormalities of the airways. Our goal was to investigate the effects of Pidotimod on RI p...

    Authors: Diletta Valentini, Chiara Di Camillo, Nadia Mirante, Valentina Marcellini, Rita Carsetti and Alberto Villani

    Citation: Italian Journal of Pediatrics 2020 46:31

    Content type: Research

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  28. The original article contains a misspelling of co-author, Christine Bodemer’s name which is presented correctly in this Correction article.

    Authors: May El Hachem, Damiano Abeni, Andrea Diociaiuti, Roberta Rotunno, Francesco Gesualdo, Giovanna Zambruno and Christine Bodemer

    Citation: Italian Journal of Pediatrics 2020 46:30

    Content type: Correction

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    The original article was published in Italian Journal of Pediatrics 2019 45:26

  29. Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis in the pediatric population worldwide and an important cause of death in developing countries. It has been demonstrated that the bala...

    Authors: Isabella Tarissi De Jacobis, Rosa Vona, Elisabetta Straface, Lucrezia Gambardella, Giulia Ceglie, Francesca de Gennaro, Ilenia Pontini, Anna Chiara Vittucci, Alessandra Carè, Camilla Cittadini, Alberto Villani and Donatella Pietraforte

    Citation: Italian Journal of Pediatrics 2020 46:29

    Content type: Research

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  30. Child vaccination is an instrument for saving millions of lives. Only one in twenty children has access to childhood vaccination in hard to reach areas in developing countries. Although studies have been done ...

    Authors: Ayal Debie and Ayenew Molla Lakew

    Citation: Italian Journal of Pediatrics 2020 46:28

    Content type: Research

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  31. CDKL5-related disorders (CDD) is an epileptic encephalopathy resulted of gene mutations of CDKL5. This study aimed to explore the development process of CDD and to expand its mutation spectrum.

    Authors: Yumei Yan, Dake He, Jing Wu, Ruolin Hou, Kun Sun and Ling Li

    Citation: Italian Journal of Pediatrics 2020 46:27

    Content type: Research

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  32. The survival of preterm babies has increased worldwide, but the risk of neuro-developmental disabilities remains high, which is of concern to both the public and professionals. The early identification of chil...

    Authors: Licia Lugli, Marisa Pugliese, Carlotta Plessi, Alberto Berardi, Isotta Guidotti, Gina Ancora, Sara Grandi, Giancarlo Gargano, Silvia Braibanti, Fabrizio Sandri, Silvia Soffritti, Elisa Ballardini, Vittoria Arena, Marcello Stella, Serafina Perrone, Sabrina Moretti…

    Citation: Italian Journal of Pediatrics 2020 46:26

    Content type: Research

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  33. Aplasia cutis congenita (ACC), classified in nine groups, is likely to be underreported, since milder isolated lesions in wellbeing newborns could often be undetected, and solitary lesions in the context of po...

    Authors: Ingrid Anne Mandy Schierz, Mario Giuffrè, Antonello Del Vecchio, Vincenzo Antona, Giovanni Corsello and Ettore Piro

    Citation: Italian Journal of Pediatrics 2020 46:25

    Content type: Research

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  34. Patients affected by acute central nervous system (ACNS) infectionsmay present different complications, including neuropsychological disorders. Nevertheless, psychopathological impairment has been rarely measu...

    Authors: Elena Bozzola, Giulia Spina, Paola Bergonzini, Mauro Bozzola, Massimiliano Raponi and Alberto Villani

    Citation: Italian Journal of Pediatrics 2020 46:23

    Content type: Research

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  35. The optimal management of PDA in very low birth weight (VLBW) infants is still controversial. Aim of our study was to investigate the management of PDA in the Italian neonatal intensive care units (NICU).

    Authors: Benjamim Ficial, Iuri Corsini, Stefano Fiocchi, Federico Schena, Irma Capolupo, Rosa Maria Cerbo, Manuela Condò, Daniela Doni, Simona La Placa, Salvatore Porzio, Katia Rossi, Sabrina Salvadori and Marilena Savoia

    Citation: Italian Journal of Pediatrics 2020 46:22

    Content type: Research

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  36. Neonatal acidaemia at birth can increase neonatal morbidity and mortality and it is predictive of neonatal asphyxia. The umbilical blood gas analysis is a valid tool for the evaluation of neonatal acidaemia. H...

    Authors: Giuseppe De Bernardo, Rita De Santis, Maurizio Giordano, Desiree Sordino, Giuseppe Buonocore and Serafina Perrone

    Citation: Italian Journal of Pediatrics 2020 46:20

    Content type: Research

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  37. The pathophysiological etiologies related with the development of Autism Spectrum Disorders (ASD) remain controversial. Different authors have studied neurotoxins such as mercury (Hg) and their relationship wi...

    Authors: Fernando Gil-Hernández, Antonio R. Gómez-Fernández, María Josede la Torre-Aguilar, Juan L. Pérez-Navero, Katherine Flores-Rojas, Pilar Martín-Borreguero and Mercedes Gil-Campos

    Citation: Italian Journal of Pediatrics 2020 46:19

    Content type: Research

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  38. The upper airways (UA) should be considered as a functional unit. Current functional anatomy divides URT in three, mutually dependent, “junction boxes”: i) the ostio-meatal complex (OMC), ii) the spheno-ethmoi...

    Authors: Attilio Varricchio, Ignazio La Mantia, Francesco Paolo Brunese and Giorgio Ciprandi

    Citation: Italian Journal of Pediatrics 2020 46:18

    Content type: Commentary

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  39. The risk factors for multi-drug resistant infection (MDRI) in the pediatric intensive care unit (PICU) remain unclear. It’s necessary to evaluate the epidemiological characteristics and risk factors for MDRI i...

    Authors: Zaihua Wang and Zhongfang Xia

    Citation: Italian Journal of Pediatrics 2020 46:17

    Content type: Research

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  40. Initial establishment of the human gut microbiota is generally believed to occur immediately following birth, involving key gut commensals such as bifidobacteria that are acquired from the mother. The subseque...

    Authors: Francesca Turroni, Christian Milani, Sabrina Duranti, Gabriele Andrea Lugli, Sergio Bernasconi, Abelardo Margolles, Francesco Di Pierro, Douwe van Sinderen and Marco Ventura

    Citation: Italian Journal of Pediatrics 2020 46:16

    Content type: Review

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  41. We report a case of a 4-year-old girl with acute dacryocystitis complicated with giant lacrimal abscess who underwent open dacryocystectomy as resolutive surgery.

    Authors: Maria Di Cicco, Elisabetta Maria Bellino, Andrea Marabotti, Laura Luti, Diego G. Peroni and Giampiero I. Baroncelli

    Citation: Italian Journal of Pediatrics 2020 46:15

    Content type: Case report

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  42. As more and more diagnostic and interventional options are becoming available for use in pediatric patients, techniques of procedural sedation analgesia (PSA) are being administered in considerably growing num...

    Authors: Harald Sauer, Marie Lobenhofer and Hashim Abdul-Khaliq

    Citation: Italian Journal of Pediatrics 2020 46:14

    Content type: Research

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  43. In recent years, medical training has significantly increased the use of simulation for teaching and evaluation. The retraining of medical personnel in Italy is entrusted to the program of Continuous Education...

    Authors: Alice Covelli, Serena Bardelli, Rosa T. Scaramuzzo, Emilio Sigali, Massimiliano Ciantelli, Marta Del Pistoia, Alessia Longo, Selene Tognarelli, Arianna Menciassi and Armando Cuttano

    Citation: Italian Journal of Pediatrics 2020 46:13

    Content type: Research

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  44. Children with chronic respiratory failure and/or sleep disordered breathing due to a broad range of diseases may require long-term ventilation to be managed at home. Advances in the use of long-term non-invasi...

    Authors: Martino Pavone, Elisabetta Verrillo, Alessandro Onofri, Serena Caggiano, Maria Beatrice Chiarini Testa and Renato Cutrera

    Citation: Italian Journal of Pediatrics 2020 46:12

    Content type: Research

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  45. Given the inadequate overall awareness of the main disease features and treatment modalities of pruritus in pediatric patients with atopic dermatitis, a multidisciplinary Italian expert group met with the majo...

    Authors: May El Hachem, Giuseppe Di Mauro, Roberta Rotunno, Simona Giancristoforo, Cristiana De Ranieri, Carla Maria Carlevaris, Maria Carmen Verga and Iride Dello Iacono

    Citation: Italian Journal of Pediatrics 2020 46:11

    Content type: Review

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  46. Preterm birth (PTB) can be caused by different factors. The factors can be classified into different categories: socio demographic, obstetric, reproductive health, medical, behavioral and nutritional related. ...

    Authors: Tariku Laelago, Tadele Yohannes and Gulima Tsige

    Citation: Italian Journal of Pediatrics 2020 46:10

    Content type: Review

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  47. The aims of the study were to determine the effects of electronic exposure on behaviors of preschoolers, which could provide scientific grounds to the control of digital screen time and usage of electronics.

    Authors: Guodong Xie, Qianye Deng, Jing Cao and Qing Chang

    Citation: Italian Journal of Pediatrics 2020 46:9

    Content type: Research

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