Articles

Pediatric meningococcocal meningitis in the acute phase: how much does it cost?

Meningococcal meningitis (MM) is known to be responsible of high cost for the Public Health Administration. Aim of the work is to calculate the costs for the hospitalization of pediatric patients affected by MM.

Authors: Elena Bozzola, Stefano Guolo, Enea Bonci, Chiara Rossetti, Mauro Bozzola, Massimiliano Raponi and Alberto Villani

Comparison of minor head trauma management in the emergency departments of a United States and Italian Children’s hospital

Pediatric head trauma management varies between emergency departments globally. Here we aim to compare the pediatric minor head trauma management between a US and Italian hospital.

Authors: Brittany M. Stopa, Stefano Amoroso, Luca Ronfani, Elena Neri, Egidio Barbi and Lois K. Lee

SIADH versus adrenal insufficiency: a life-threatening misdiagnosis

Primary adrenal insufficiency (PAI) in children is an uncommon but severe condition which can be either inherited or acquired. It consists in clinical manifestation of defective production or ineffective actio...

Authors: Stefano Pintaldi, Angela Lora, Katy Vecchiato, Andrea Taddio and Egidio Barbi

The association of prenatal and postnatal macrolide exposure with subsequent development of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis

The association between macrolides use and subsequent occurrence of infantile hypertrophic pyloric stenosis (IHPS) is still debatable. The aim of this study was to conduct a systematic review and meta-analysis...

Authors: Hamdi H. Almaramhy and Abdulmohsen H. Al-Zalabani

Correction to: Evaluation of serum 25-Hydroxy vitamin D levels in children with autism Spectrum disorder

The original article [1] contained an error in author Mohammad Taghi Mansouri’s name.

Authors: Ali Asghar Arastoo, Hesam Khojastehkia, Zahra Rahimi, Morteza Abdullatif Khafaie, Syed Ahmad Hosseini, Mohammad Taghi Mansouri, Shabnam Yosefyshad, Maryam Abshirini, Karimimalekabadi Noshin and Maria Cheraghi

Correction to: Morphine-induced supraventricular tachycardia in near-term fetus

The original article [1] contained an error whereby all authors’ names were mistakenly inverted.

Authors: Vincenzo Zanardo, Alphonse Simbi, Matteo Parotto, Lorenzo Severino, Riccardo Carta, Pietro Guerrini and Gianluca Straface

Analysis of the predicting factors of recurrent wheezing in infants

Clinically, asthma in children under 5 years old is under estimated because lack of diagnostic criteria. The current study was, therefore, designed to identify the predicting factors for recurrent wheezing in ...

Authors: Jia Zhai, Yingxue Zou, Jie Liu, Xingnan Jin, Cuian Ma, Jiao Li, Run Guo and Bing Huang

Effect of vitamin D3 seasonal supplementation with 1500 IU/day in north Italian children (DINOS study)

The appropriate dose of vitamin D supplementation in children is still debated. We calculated that the recommended dose of 600–1000 IU vitamin D3/day is not sufficient to reach a serum 25-hydroxyvitamin D (25-...

Authors: Stefano Mazzoleni, Giovanna Magni and Daniela Toderini

Dynamic Ghrelin and GH serum levels during combined simultaneous arginine clonidine stimulation test in children with dwarfism

Combined simultaneous arginine clonidine stimulation (CSACS) test represents a more appropriate stimulus to detect Ghrelin, for it does not affect glucose metabolism.

Authors: Guangzhong Zhou and Rongzeng Du

Prelacteal feeding practice and its associated factors among mothers of children age less than 24 months old in Southern Ethiopia

Although Pre-lacteal feeding is a barrier for implementation of optimal breastfeeding practices and increases the risk of neonatal illness and mortality, still it is continued as a deep-rooted nutritional malp...

Authors: Esayas Aydiko Amele, Birhanu wondimeneh Demissie, Kalkidan Wondwossen Desta and Emebet Berhane Woldemariam

An association analysis to identify genetic variants linked to asthma and rhino-conjunctivitis in a cohort of Sicilian children

Asthma and rhino-conjunctivitis are common chronic diseases in childhood. In this cross-sectional study, we performed a gene association analysis with current asthma and rhino-conjunctivitis in a cohort of Sic...

Authors: Gianluca Sottile, Giuliana Ferrante, Marta Torregrossa, Fabio Cibella, Giovanna Cilluffo, Salvatore Fasola, Riccardo Alessandro, Gregorio Seidita, Giovanni Viegi and Stefania La Grutta

Omalizumab in children with severe allergic disease: a case series

Currently, severe allergic asthma and food allergy in children represent an important public health problem with medical, psychosocial and economic impacts. Omalizumab is a humanized monoclonal anti-IgE antibo...

Authors: Giuseppe Crisafulli, Lucia Caminiti, Fernanda Chiera, Stefania Arasi, Giuseppina Salzano, Ilenia Panasiti, Andrea Barbalace and Giovanni Battista Pajno

Malnutrition, morbidity and infection in the informal settlements of Nairobi, Kenya: an epidemiological study

Malnutrition constitutes one of the major public health challenges throughout the developing world. Urban poverty and malnutrition have been on the rise, with an increased rate of morbidity. We herein explore ...

Authors: Maria Vittoria De Vita, Carlo Scolfaro, Bruna Santini, Antonella Lezo, Federico Gobbi, Dora Buonfrate, Elizabeth W. Kimani-Murage, Teresiah Macharia, Milka Wanjohi, Jacopo Mattia Rovarini and Gianfranco Morino

The role of extracellular histones in systemic-onset juvenile idiopathic arthritis

To explore the effects of extracellular histones released by activated neutrophils on systemic-onset juvenile idiopathic arthritis (SoJIA), and to study the change of serum histone level between the active and...

Authors: Xiao Hu, Qiuling Xie, Xi Mo and Yanliang Jin

Efficacy of the gluten free diet in the management of functional gastrointestinal disorders: a systematic review on behalf of the Italian Society of Paediatrics

Functional gastrointestinal disorders (FGIDs) are characterized by chronic/recurrent gastrointestinal symptoms not related to organic disorders. Due to the limited treatment options and to the perception of su...

Authors: Elena Scarpato, Renata Auricchio, Francesca Penagini, Angelo Campanozzi, Gian Vincenzo Zuccotti and Riccardo Troncone

Stage 4 s neuroblastoma: features, management and outcome of 268 cases from the Italian Neuroblastoma Registry

Infants diagnosed with stage 4 s neuroblastoma commonly experience spontaneous disease regression, with few succumbing without response to therapy. We analyzed a large cohort of such infants enrolled in the It...

Authors: Bruno De Bernardi, Andrea Di Cataldo, Alberto Garaventa, Paolo Massirio, Elisabetta Viscardi, Marta Giorgia Podda, Aurora Castellano, Paolo D’Angelo, Elisa Tirtei, Fraia Melchionda, Simona Vetrella, Francesco De Leonardis, Carmelita D’Ippolito, Annalisa Tondo, Antonella Nonnis, Giovanni Erminio…

Novel DNA variation of GPR54 gene in familial central precocious puberty

Puberty can be considered the end point of a maturation process which is defined by the dynamic interactions of genes and environmental factors during prenatal and postnatal development. Kisspeptin/G protein-c...

Authors: Nosrat Ghaemi, Martha Ghahraman, Samaneh Noroozi Asl, Rahim Vakili, Fatemeh Fardi Golyan, Meysam Moghbeli and Mohammad Reza Abbaszadegan

Inequalities in infant mortality in Italy

All the children of the world should be born equal, but this is not so: even in Italy, there are striking differences already at birth. Neonatal and infant mortality are accurate indexes to assess the demograp...

Authors: Silvia Simeoni, Luisa Frova and Mario De Curtis

Maternal HIV infection and preeclampsia increased risk of low birth weight among newborns delivered at University of Gondar specialized referral hospital, Northwest Ethiopia, 2017

Globally, more than 20 million infants are born with low birth weight. The risk of neonatal mortality among low birth weight infants is 25 to 30 times greater than neonates with birth weight ≥ 2500 g. Low birth w...

Authors: Daniale Tekelia Ekubagewargies, Destaye Guadie Kassie and Wubet Worku Takele

The effects of position on gastric residual volume of premature infants in NICU

Nutrition cares are of the main measures to save premature infants. In this regard, proper positioning is one of the key measures that is done by nurses; still there is a paucity of studies in this field and t...

Authors: Alireza Khatony, Alireza Abdi, Batol Karimi, Abbas Aghaei and Hamidreza Saeidi Brojeni

Authors’ reply - anaphylactic shock with methylprednisolone, Kounis syndrome and Hypersitivity to corticosteroids: a clinical paradox

In our letter, we comment the paper of Kounis et al., that highlights a poor-known clinical entity determined by systemic use of corticosteroids, the so-called “Kounis syndrome type I”. We appreciated and shar...

Authors: F. Porcaro, M. G. Paglietti, A. Diamanti, F. Petreschi, A. Schiavino, V. Negro, V. Pecora, A. Fiocchi and R. Cutrera

Hepatomegaly and type 1 diabetes: a clinical case of Mauriac’s syndrome

Hepatic glycogenosis is characterized by excessive glycogen accumulation in hepatocytes and represents a complication of poor controlled type 1 diabetes. It can be caused by excessive insulin doses or recurren...

Authors: Fortunato Lombardo, Stefano Passanisi, Albino Gasbarro, Giovanni Tuccari, Antonio Ieni and Giuseppina Salzano

Survival and predictors among preterm neonates admitted at University of Gondar comprehensive specialized hospital neonatal intensive care unit, Northwest Ethiopia

Prematurity accounts about 1 million neonatal deaths worldwide and the second causes of both neonatal and under five-child mortality. Neonatal mortality accounts for 43% of under-five child mortality in Ethiop...

Authors: Ayenew Engida Yismaw, Abebaw Addis Gelagay and Malede Mequanent Sisay

A modified physiologic test for bronchopulmonary dysplasia: a clinical tool for weaning from CPAP and/or oxygen-therapy the premature babies?

A physiologic test for estimating BPD rate has been developed by Walsh and collaborators. Actually there are not standard criteria for weaning from CPAP and/or oxygen therapy the premature babies. Aim of this ...

Authors: Giovanni Vento, Valentina Vendettuoli, Claudia Aurilia, Milena Tana, Chiara Tirone, Alessandra Lio, Piero Giuseppe Matassa, Francesca Priolo, Piero Catenazzi, Mirta Corsello, Enrico Zecca and Fabio Mosca

Postnatal length and weight growth velocities according to Fenton reference and their associated perinatal factors in healthy late preterm infants during birth to term-corrected age: an observational study

Optimum early postnatal growth is critical for early and later health of preterm infants. Postnatal length and weight growth velocities and their associated perinatal factors in healthy late preterm infants wi...

Authors: Li Zhang, Yan Li, Shuang Liang, Xiao-Juan Liu, Feng-Ling Kang and Gui-Mei Li

Listeria monocytogenes meningitis in immunocompetent and healthy children: a case report and a review of the literature

Listeria monocytogenes is a gram-positive bacteria generally transmitted to humans through ingestion of contaminated food. It typically infects high risk subjects, such as pregnant women, neonates, the elderly an...

Authors: Massimo Luca Castellazzi, Paola Marchisio and Samantha Bosis

Is preterm birth associated with asthma among children from birth to 17 years old? -A study based on 2011-2012 US National Survey of Children’s Health

Preterm birth can interrupt lung development in utero and is associated with early life factors, which adversely affects the developing respiratory system. Studies on preterm birth and asthma risk are comparat...

Authors: Jie Zhang, Chenchao Ma, Aimin Yang, Rongqiang Zhang, Jiannan Gong and Fengfeng Mo

74th Congress of the Italian Society of Pediatrics

Authors:

Evaluation of serum 25-Hydroxy vitamin D levels in children with autism Spectrum disorder

Vitamin D plays an important role in etiology of Autism Spectrum Disorders (ASDs). We aimed to evaluate the serum 25 - hydroxyl vitamin D level among children with ASDs in Ahvaz city, Iran.

Authors: Ali Asghar Arastoo, Hesam Khojastehkia, Zahra Rahimi, Morteza Abdullatif Khafaie, Syed Ahmad Hosseini, Mohammad Taghi Mansouri, Shabnam Yosefyshad, Maryam Abshirini, Noshin Karimimalekabadi and Maria Cheraghi

Re-comparing of three different epidemic seasons of bronchiolitis: different prophylaxis approaches

During the last epidemic season of bronchiolitis (S2, years 2016–2017) we performed a single Centre analysis in inborn infant of 30^+ 0–32^+ 6 gestational age and age < 12 months who did not receive prophylaxis wit...

Authors: Simonetta Picone, Adele Fabiano, Davide Roma, Federico Di Palma and Piermichele Paolillo

SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children

Drug hypersensitivity reactions (DHRs) in childhood are mainly caused by betalactam or non-betalactam antibiotics, and non-steroidal anti-inflammatory drugs (NSAIDs). Laboratory tests for identifying children ...

Authors: Carlo Caffarelli, Fabrizio Franceschini, Davide Caimmi, Francesca Mori, Lucia Diaferio, Dora Di Mauro, Carla Mastrorilli, Stefania Arasi, Simona Barni, Paolo Bottau, Silvia Caimmi, Fabio Cardinale, Pasquale Comberiati, Giuseppe Crisafulli, Lucia Liotti, Umberto Pelosi…

Gambling disorder in adolescents: what do we know about this social problem and its consequences?

Gambling disorder (GD) is a psychiatric condition and it is characterized by a maladaptive pattern of gambling behavior that persists despite negative consequences in major areas of life functioning. In Italy,...

Authors: Pietro Ferrara, Giulia Franceschini and Giovanni Corsello

Off-label drugs use in pediatric palliative care

Paediatric palliative care (PPC) aim to ensure the control of symptoms and the best possible quality of life for patients whose underlying disease, characterized by an unstoppable evolution and negative progno...

Authors: Lucia De Zen, Federico Marchetti, Egidio Barbi and Franca Benini

Genomics of neonatal sepsis: has-miR-150 targeting BCL11B functions in disease progression

Neonatal sepsis is an inflammatory systemic syndrome, which is a major cause of morbidity and mortality in premature infants. We analyzed the expression profile data of E-MTAB-4785 to reveal the pathogenesis o...

Authors: Li Huang, Lixing Qiao, Huan Zhu, Li Jiang and Liping Yin

Anaphylactic shock with methylprednisolone, Kounis syndrome and hypersensitivity to corticosteroids: a clinical paradox

Corticosteroids are widely used for the treatment of allergic reactions but paradoxically themselves may induce acute, delayed, local or systemic allergic reactions and even anaphylaxis with Kounis syndrome. T...

Authors: Nicholas G. Kounis, Ioanna Koniari, George D. Soufras and Emmanouil Chourdakis

Low birth weight and its associated factors in Ethiopia: a systematic review and meta-analysis

Different primary studies in Ethiopia showed the burden of low birth weight. However, variation among those studies was seen. This study was aimed to estimate the national prevalence and associated factors of ...

Authors: Aklilu Endalamaw, Eshetu Haileselassie Engeda, Daniale Tekelia Ekubagewargies, Getaneh Mulualem Belay and Mekuriaw Alemayehu Tefera

Perception of childhood anaemia among mothers in Kumasi: a quantitative approach

Anaemia is the world’s second cause of disability and it affects over half of pre-school children in developing countries and at least 30–40% in industrial countries. In poorer malaria-endemic countries, anemi...

Authors: Reindolf Anokye, Enoch Acheampong, Anthony Kwaku Edusei, Wisdom Kwadwo Mprah, Justice Ofori-Amoah, Vida Maame Kissiwaa Amoah and Vincent Ekow Arkorful

An early diagnosis of trichorhinophalangeal syndrome type 1: a case report and a review of literature

Trichorhinophalangeal syndrome (TRPS) is a rare autosomal dominant disorder caused by defects involving the TRPS1 gene. It exhibits distinctive craniofacial, ectodermal and skeletal abnormalities, such as sparse ...

Authors: Giulia Trippella, Paolo Lionetti, Sara Naldini, Francesca Peluso, Matteo Della Monica and Stefano Stagi

Hospital clinical pathways for children affected by juvenile idiopathic arthritis

Juvenile idiopathic arthritis (JIA) is the most common pediatric chronic rheumatic disease, which requires constant follow-up over the years, due to relapses during its progression. To maintain a good quality ...

Authors: L. Cavazzana, M. Fornili, G. Filocamo, C. Agostoni, F. Auxilia and S. Castaldi

Differentiating Kawasaki disease from urinary tract infection in febrile children with pyuria and C-reactive protein elevation

Kawasaki disease (KD) is sometimes confused with urinary tract infection (UTI) because both can present with pyuria and C-reactive protein (CRP) elevation. The present study investigated the clinical and labor...

Authors: Seung Beom Han and Soo-Young Lee

West-Nile virus encephalitis in an immunocompetent pediatric patient: successful recovery

West Nile virus (WNV) is a mosquito-borne RNA virus belonging to the Flaviviridae family. Symptomatic infection happens in only about 20% of the cases, while WNV neuroinvasive disease (WNND) is rare and accounts ...

Authors: Salvatore Savasta, Francesca Rovida, Thomas Foiadelli, Anna Maria Campana, Elena Percivalle, Gian Luigi Marseglia and Fausto Baldanti

Phenotypic testicular abnormalities and pubertal development in boys with McCune-Albright syndrome

Aim of this survey is to review the few available literature data on pathophysiologic and clinical aspects of pubertal development in boys with McCune-Albright syndrome (MAS). On the basis of such analysis, we...

Authors: Tommaso Aversa, Giuseppina Zirilli, Domenico Corica, Filippo De Luca and Malgorzata Wasniewska

The role of imaging in the skeletal involvement of mucopolysaccharidoses

This article discusses the role of imaging modalities including radiography, multi-detector computed tomography, magnetic resonance imaging, and ultrasound in diagnosing and monitoring skeletal abnormalities i...

Authors: Vincenzo Spina, Domenico Barbuti, Alberto Gaeta, Stefano Palmucci, Ernesto Soscia, Marco Grimaldi, Antonio Leone, Renzo Manara and Gabriele Polonara

Clinical hints to diagnosis of attenuated forms of Mucopolysaccharidoses

The mucopolysaccharidoses (MPS) are clinically similar but also heterogeneous in terms of major or minor involvement of different organs/systems, burden of disease, and rate of progression. The attenuated form...

Authors: Miriam Rigoldi, Elena Verrecchia, Raffaele Manna and Maria Teresa Mascia

The new frame for Mucopolysaccharidoses

Mucopolysaccharidoses (MPS) are genetic, progressive, lysosomal storage disorders affecting virtually all organs and systems. The first MPS were clinically identified about 100 years ago. Nowadays, the enzyme ...

Authors: Rossella Parini and Andrea Biondi

Possible strategies to cross the blood–brain barrier

The mucopolysaccharidoses (MPS) are a heterogeneous group of in-born metabolic conditions caused by genetic defects that result in the absence or severe deficiency of one of the lysosomal hydrolases responsibl...

Authors: Cinzia M. Bellettato and Maurizio Scarpa

Early diagnosis and management of cardiac manifestations in mucopolysaccharidoses: a practical guide for paediatric and adult cardiologists

Mucopolysaccharidoses (MPS) are a group of hereditary disorders caused by lysosomal storage of glycosaminoglycans (GAGs) and characterized by a wide variability of phenotypes from severe fetal-neonatal forms t...

Authors: Lucia Boffi, Pierluigi Russo and Giuseppe Limongelli

Cerebral and occipito-atlanto-axial involvement in mucopolysaccharidosis patients: clinical, radiological, and neurosurgical features

Neurosurgical features of mucopolysaccharidosis (MPS) patients mainly involve the presence of cranio-vertebral junction (CVJ) abnormalities and the development of communicating hydrocephalus. CVJ pathology is ...

Authors: Carlo Giussani, Lelio Guida, Francesco Canonico and Erik P. Sganzerla

Ocular features in mucopolysaccharidosis: diagnosis and treatment

Mucopolysaccharidoses (MPS) are a group of rare lysosomal storage disorders characterized by the accumulation of glycosaminoglycans (GAGs) in different parts of the eye. Ocular problems are very common in MPS ...

Authors: Alessandra Del Longo, Elena Piozzi and Fiammetta Schweizer

Mucopolysaccharidoses: early diagnostic signs in infants and children

Mucopolysaccharidoses (MPS) comprise a group of lysosomal disorders that are characterized by progressive, systemic clinical manifestations and a coarse phenotype. The different types, having clinical, biochem...

Authors: Cinzia Galimberti, Annalisa Madeo, Maja Di Rocco and Agata Fiumara