Articles

Nationwide survey of neonatal transportation practices in Italy

Despite regionalization of perinatal care provides for the “in utero” transfer of high-risk pregnancies, there will always be a number of neonates who undergo acute inter-facility transport. The presence of a ...

Authors: Maurizio Gente, Roberto Aufieri, Rocco Agostino, Tiziana Fedeli, Maria Grazia Calevo, Paolo Massirio and Carlo Bellini

Prevalence, types, and malformations in congenital anomalies of the kidney and urinary tract in newborns: a retrospective hospital-based study

Congenital anomalies of the kidney and urinary tract (CAKUTs) are some of the most common birth defects affecting newborns. CAKUTs often have poor birth outcomes owing to the limited experience of physicians i...

Authors: Zhong-yi Li, Yan-min Chen, Li-qian Qiu, Dan-qing Chen, Chong-gao Hu, Jian-yun Xu and Xiao-hui Zhang

Two novel mutations in exon 3 of PHOX2B gene: think about congenital central hypoventilation syndrome in patients with Hirschsprung disease

Congenital central hypoventilation syndrome (CCHS) is characterized by alveolar hypoventilation increasing during sleep and affected patients are unable to perceive and respond to hypercarbia with increased ve...

Authors: Maria Giovanna Paglietti, Claudio Cherchi, Federica Porcaro, Emanuele Agolini, Alessandra Schiavino, Francesca Petreschi, Antonio Novelli and Renato Cutrera

Abstracts from the 24th Congress of the Italian Society of Cystic Fibrosis and the 14th National Congress of Cystic Fibrosis Italian Society

Authors:

Factors associated with low birth weight among babies born at Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia

Low birth weight is defined as infant born with weight of less than 2500 g. It is one of the major public health problems worldwide. In Ethiopia, there are limited evidences on factors contributing to low birt...

Authors: Melese Siyoum and Teshome Melese

Influenza vaccination: opinions of health care professionals working in pediatric emergency departments

Vaccine coverage of health care professionals against influenza is still low in Italy, as well as in other European countries.

Authors: Luciano Pinto, Raffaele Falsaperla, Alberto Villani, Giovanni Corsello, Roberto Del Gado, Adolfo Mazzeo and Riccardo Lubrano

Treatment outcomes and factors affecting time-to-recovery from severe acute malnutrition in 6–59 months old children admitted to a stabilization center in Southern Ethiopia: A retrospective cohort study

Despite improving access to Severe Acute Malnutrition (SAM) management, information on the quality of the service, as measured by timely recovery, is scare. This study is designed to assess treatment outcomes ...

Authors: Anteneh Fikrie, Akalewold Alemayehu and Samson Gebremedhin

Preterm birth: seven-year retrospective study in a single centre population

Preterm birth is a health and social problem, considered the leading cause of neonatal mortality worldwide. It is associated with higher rates of neurodevelopmental morbidity, sensorineural impairments and oth...

Authors: Roberta Granese, Eloisa Gitto, Gabriella D’Angelo, Raffaele Falsaperla, Giovanni Corsello, Donatella Amadore, Gloria Calagna, Ilaria Fazzolari, Roberta Grasso and Onofrio Triolo

Neonatal respiratory support strategies for the management of extremely low gestational age infants: an Italian survey

We aimed to survey Delivery Room and Neonatal Intensive Care Unit (NICU) respiratory strategies dedicated to the extremely low gestational age newborn (ELGAN – GA < 28 wks) in Italy.

Authors: Flavia Petrillo, Camilla Gizzi, Gianfranco Maffei, Piero G. Matassa, Maria Luisa Ventura, Cinzia Ricci, Roberta Pastorino and Giovanni Vento

Ventricular bigeminy and trigeminy caused by hypophosphataemia during diabetic ketoacidosis treatment: a case report

Hypophosphatemia has many causes, and is often encountered during DKA (Diabetic Ketoacidosis) treatment. However, it rarely requires clinical intervention.

Authors: Konrad Miszczuk, Joanna Mroczek-Wacinska, Robert Piekarski, Beata Wysocka- Lukasik, Renata Jawniak and Iwona Ben-Skowronek

Vitamin D inhibits pro-inflammatory cytokines in the airways of cystic fibrosis patients infected by Pseudomonas aeruginosa- pilot study

Vitamin D plays an important role in inflammatory responses after antigen exposure. Interleukin-23 (Il-23) promotes Il-17-dependent inflammation during Pseudomonas aeruginosa (P. aeruginosa) pulmonary infection. ...

Authors: M. Olszowiec-Chlebna, A. Koniarek-Maniecka, A. Brzozowska, A. Błauż, B. Rychlik and I. Stelmach

The gliadin-CFTR connection: new perspectives for the treatment of celiac disease

Familial loss-of-function mutations of the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) channel protein cause cystic fibrosis (CF), the most frequent inherited life-threatenin...

Authors: Luigi Maiuri, Valeria R. Villella, Valeria Raia and Guido Kroemer

Medico-legal considerations on “Lotus Birth” in the Italian legislative framework

The term “Lotus Birth” identifies the practice of not cutting the umbilical cord and of leaving the placenta attached to the newborn after its expulsion until it detaches spontaneously, which generally occurs ...

Authors: Alessandro Bonsignore, Francesca Buffelli, Rosagemma Ciliberti, Francesco Ventura, Andrea Molinelli and Ezio Fulcheri

Long-term follow-up of newborns at neurological risk

In order to give a new contribution to the knowledge of the psycho-physical, behavioral and socio-relational development of the individuals who were born at neurological risk, we have carried out a research wo...

Authors: Enrico Gasparrini, Francesca Rosati and Maria Teresa Gaetti

Association of neural tube defects with maternal alterations and genetic polymorphisms in one-carbon metabolic pathway

Neural tube defects (NTDs) are birth defects of the brain, spine, or spinal cord invoked by the insufficient intake of folic acid in the early stages of pregnancy and have a complex etiology involving both gen...

Authors: Chun-Quan Cai, Yu-Lian Fang, Jian-Bo Shu, Lin-Sheng Zhao, Rui-Ping Zhang, Li-Rong Cao, Yi-Zheng Wang, Xiu-Fang Zhi, Hua-Lei Cui, Ou-Yan Shi and Wei Liu

An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache

Migraine is one of the most prevalent chronic pain manifestations of childhood. Despite the multitude of available treatments, parents are often concerned about chronic therapies and pediatricians have insuffi...

Authors: Filomena Moscano, Michela Guiducci, Lucia Maltoni, Pasquale Striano, Maria Giuseppina Ledda, Francesco Zoroddu, Umberto Raucci, Maria Pia Villa and Pasquale Parisi

10-year experience with umbilical cord blood IgE and microbiome therapy

The benefit of probiotics in newborn children in relation to allergy and general morbidity later in life appears to be controversial. Allergic diseases represent an increasingly important health problem worldw...

Authors: Jiří Liška, Konrad Siala, Blanka Čuláková, Václav Holeček, Štěpánka Sobotová, Josef Sýkora and František Šefrna

Assessment of Preptin peptide level in the sera of rachitic children and in breast milk of their mothers

Preptin is a 34-residue pancreatic hormone that stimulates osteoblast proliferation and reduces osteoblast apoptosis.

Authors: Gihan M. Bebars, Salem A. Sallam, Shereen S. Gaber and Alshimaa H. Abdelaziz

Why is “early childhood intensive care” an Italian association of neonatology study group?

To date, a large number of children are hospitalized inappropriately in adult intensive care units, where the minimum standards of care are not applied to young patients. It is well-known that the child is not...

Authors: Nicola Pozzi, Gabriella D’Angelo and Eloisa Gitto

Combined effect of different factors on weight status and cardiometabolic risk in Italian adolescents

The observed increase in body weight and cardiometabolic risk (CR) in youth from developed countries contributes to the global burden of chronic diseases in adult age. The aim of this work is to provide a patt...

Authors: Antonino Bianco, Anna Rita Filippi, João Breda, Vincenza Leonardi, Antonio Paoli, Luca Petrigna, Antonio Palma and Garden Tabacchi

Consensus communication strategies to improve doctor-patient relationship in paediatric severe asthma

Asthma is a chronic inflammatory disease that is very common among youth worldwide. The burden of this illness is very high not only considering financial costs but also on emotional and social functioning. Gu...

Authors: Antonietta Cappuccio, Filomena Bugliaro, Silvia Maria Elena Caimmi, Valeria Caldarelli, Lucia Caminiti, Enza D’Auria, Emanuela di Palmo, Marzia Duse, Alessandro Giovanni Fiocchi, Francesco Gesualdo, Ahmad Kantar, Enrico Lombardi, Anna Lucania, Margherita Marchiani, Maria Giulia Marini, Gianluigi Marseglia…

Vitamin K deficiency bleeding in an apparently healthy newborn infant: the compelling need for evidence-based recommendation

Vitamin K is a key point for guarantee normal blood clotting and its level in newborns is commonly low, so a supplementation after delivery is mandatory.

Authors: Simone Ceratto and Francesco Savino

Globalization of pediatric research: pharmacological RCTs in Latin America

Globalization caused a shift in trial locations towards low-middle income countries, raising ethical concerns. These include the risk that conditions primarily affecting children in these countries will be neg...

Authors: Federica Arienti, Claudia Pansieri, Chiara Pandolfini, Andrea Biondi and Maurizio Bonati

Can we still do something-and what?-for a seemingly missing syndrome?

Although several modifiable risk factors have been identified, and prone and side sleep positions were identified as preventing sudden infant death syndrome (SIDS), the epidemiology of sudden unexpected deaths...

Authors: Rita Campi and Maurizio Bonati

Not only Alagille syndrome. Syndromic paucity of interlobular bile ducts secondary to HNF1β deficiency: a case report and literature review

paucity of interlobular bile ducts is an important observation at liver biopsy in the diagnostic work-up of neonatal cholestasis. To date, other than in the Alagille syndrome, syndromic paucity of interlobular...

Authors: Michele Pinon, Michele Carboni, Davide Colavito, Fabio Cisarò, Licia Peruzzi, Antonio Pizzol, Giulia Calosso, Ezio David and Pier Luigi Calvo

Italian translation, cultural adaptation, and pilot testing of a questionnaire to assess family burden in inherited ichthyoses

Inherited ichthyoses are rare disorders characterized by generalized skin scaling. Among them, autosomal recessive congenital ichthyoses (ARCI) form a major subgroup presenting lifelong and severely disabling ...

Authors: May El Hachem, Damiano Abeni, Andrea Diociaiuti, Roberta Rotunno, Francesco Gesualdo, Giovanna Zambruno and Christine Bodermer

Pediatric meningococcocal meningitis in the acute phase: how much does it cost?

Meningococcal meningitis (MM) is known to be responsible of high cost for the Public Health Administration. Aim of the work is to calculate the costs for the hospitalization of pediatric patients affected by MM.

Authors: Elena Bozzola, Stefano Guolo, Enea Bonci, Chiara Rossetti, Mauro Bozzola, Massimiliano Raponi and Alberto Villani

Comparison of minor head trauma management in the emergency departments of a United States and Italian Children’s hospital

Pediatric head trauma management varies between emergency departments globally. Here we aim to compare the pediatric minor head trauma management between a US and Italian hospital.

Authors: Brittany M. Stopa, Stefano Amoroso, Luca Ronfani, Elena Neri, Egidio Barbi and Lois K. Lee

SIADH versus adrenal insufficiency: a life-threatening misdiagnosis

Primary adrenal insufficiency (PAI) in children is an uncommon but severe condition which can be either inherited or acquired. It consists in clinical manifestation of defective production or ineffective actio...

Authors: Stefano Pintaldi, Angela Lora, Katy Vecchiato, Andrea Taddio and Egidio Barbi

Correction to: Evaluation of serum 25-Hydroxy vitamin D levels in children with autism Spectrum disorder

The original article [1] contained an error in author Mohammad Taghi Mansouri’s name.

Authors: Ali Asghar Arastoo, Hesam Khojastehkia, Zahra Rahimi, Morteza Abdullatif Khafaie, Syed Ahmad Hosseini, Mohammad Taghi Mansouri, Shabnam Yosefyshad, Maryam Abshirini, Karimimalekabadi Noshin and Maria Cheraghi

Correction to: Morphine-induced supraventricular tachycardia in near-term fetus

The original article [1] contained an error whereby all authors’ names were mistakenly inverted.

Authors: Vincenzo Zanardo, Alphonse Simbi, Matteo Parotto, Lorenzo Severino, Riccardo Carta, Pietro Guerrini and Gianluca Straface

The association of prenatal and postnatal macrolide exposure with subsequent development of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis

The association between macrolides use and subsequent occurrence of infantile hypertrophic pyloric stenosis (IHPS) is still debatable. The aim of this study was to conduct a systematic review and meta-analysis...

Authors: Hamdi H. Almaramhy and Abdulmohsen H. Al-Zalabani

Analysis of the predicting factors of recurrent wheezing in infants

Clinically, asthma in children under 5 years old is under estimated because lack of diagnostic criteria. The current study was, therefore, designed to identify the predicting factors for recurrent wheezing in ...

Authors: Jia Zhai, Yingxue Zou, Jie Liu, Xingnan Jin, Cuian Ma, Jiao Li, Run Guo and Bing Huang

Effect of vitamin D3 seasonal supplementation with 1500 IU/day in north Italian children (DINOS study)

The appropriate dose of vitamin D supplementation in children is still debated. We calculated that the recommended dose of 600–1000 IU vitamin D3/day is not sufficient to reach a serum 25-hydroxyvitamin D (25-...

Authors: Stefano Mazzoleni, Giovanna Magni and Daniela Toderini

Dynamic Ghrelin and GH serum levels during combined simultaneous arginine clonidine stimulation test in children with dwarfism

Combined simultaneous arginine clonidine stimulation (CSACS) test represents a more appropriate stimulus to detect Ghrelin, for it does not affect glucose metabolism.

Authors: Guangzhong Zhou and Rongzeng Du

An association analysis to identify genetic variants linked to asthma and rhino-conjunctivitis in a cohort of Sicilian children

Asthma and rhino-conjunctivitis are common chronic diseases in childhood. In this cross-sectional study, we performed a gene association analysis with current asthma and rhino-conjunctivitis in a cohort of Sic...

Authors: Gianluca Sottile, Giuliana Ferrante, Marta Torregrossa, Fabio Cibella, Giovanna Cilluffo, Salvatore Fasola, Riccardo Alessandro, Gregorio Seidita, Giovanni Viegi and Stefania La Grutta

Prelacteal feeding practice and its associated factors among mothers of children age less than 24 months old in Southern Ethiopia

Although Pre-lacteal feeding is a barrier for implementation of optimal breastfeeding practices and increases the risk of neonatal illness and mortality, still it is continued as a deep-rooted nutritional malp...

Authors: Esayas Aydiko Amele, Birhanu wondimeneh Demissie, Kalkidan Wondwossen Desta and Emebet Berhane Woldemariam

The role of extracellular histones in systemic-onset juvenile idiopathic arthritis

To explore the effects of extracellular histones released by activated neutrophils on systemic-onset juvenile idiopathic arthritis (SoJIA), and to study the change of serum histone level between the active and...

Authors: Xiao Hu, Qiuling Xie, Xi Mo and Yanliang Jin

Omalizumab in children with severe allergic disease: a case series

Currently, severe allergic asthma and food allergy in children represent an important public health problem with medical, psychosocial and economic impacts. Omalizumab is a humanized monoclonal anti-IgE antibo...

Authors: Giuseppe Crisafulli, Lucia Caminiti, Fernanda Chiera, Stefania Arasi, Giuseppina Salzano, Ilenia Panasiti, Andrea Barbalace and Giovanni Battista Pajno

Malnutrition, morbidity and infection in the informal settlements of Nairobi, Kenya: an epidemiological study

Malnutrition constitutes one of the major public health challenges throughout the developing world. Urban poverty and malnutrition have been on the rise, with an increased rate of morbidity. We herein explore ...

Authors: Maria Vittoria De Vita, Carlo Scolfaro, Bruna Santini, Antonella Lezo, Federico Gobbi, Dora Buonfrate, Elizabeth W. Kimani-Murage, Teresiah Macharia, Milka Wanjohi, Jacopo Mattia Rovarini and Gianfranco Morino

Inequalities in infant mortality in Italy

All the children of the world should be born equal, but this is not so: even in Italy, there are striking differences already at birth. Neonatal and infant mortality are accurate indexes to assess the demograp...

Authors: Silvia Simeoni, Luisa Frova and Mario De Curtis

Novel DNA variation of GPR54 gene in familial central precocious puberty

Puberty can be considered the end point of a maturation process which is defined by the dynamic interactions of genes and environmental factors during prenatal and postnatal development. Kisspeptin/G protein-c...

Authors: Nosrat Ghaemi, Martha Ghahraman, Samaneh Noroozi Asl, Rahim Vakili, Fatemeh Fardi Golyan, Meysam Moghbeli and Mohammad Reza Abbaszadegan

Efficacy of the gluten free diet in the management of functional gastrointestinal disorders: a systematic review on behalf of the Italian Society of Paediatrics

Functional gastrointestinal disorders (FGIDs) are characterized by chronic/recurrent gastrointestinal symptoms not related to organic disorders. Due to the limited treatment options and to the perception of su...

Authors: Elena Scarpato, Renata Auricchio, Francesca Penagini, Angelo Campanozzi, Gian Vincenzo Zuccotti and Riccardo Troncone

Stage 4 s neuroblastoma: features, management and outcome of 268 cases from the Italian Neuroblastoma Registry

Infants diagnosed with stage 4 s neuroblastoma commonly experience spontaneous disease regression, with few succumbing without response to therapy. We analyzed a large cohort of such infants enrolled in the It...

Authors: Bruno De Bernardi, Andrea Di Cataldo, Alberto Garaventa, Paolo Massirio, Elisabetta Viscardi, Marta Giorgia Podda, Aurora Castellano, Paolo D’Angelo, Elisa Tirtei, Fraia Melchionda, Simona Vetrella, Francesco De Leonardis, Carmelita D’Ippolito, Annalisa Tondo, Antonella Nonnis, Giovanni Erminio…

Maternal HIV infection and preeclampsia increased risk of low birth weight among newborns delivered at University of Gondar specialized referral hospital, Northwest Ethiopia, 2017

Globally, more than 20 million infants are born with low birth weight. The risk of neonatal mortality among low birth weight infants is 25 to 30 times greater than neonates with birth weight ≥ 2500 g. Low birth w...

Authors: Daniale Tekelia Ekubagewargies, Destaye Guadie Kassie and Wubet Worku Takele

The effects of position on gastric residual volume of premature infants in NICU

Nutrition cares are of the main measures to save premature infants. In this regard, proper positioning is one of the key measures that is done by nurses; still there is a paucity of studies in this field and t...

Authors: Alireza Khatony, Alireza Abdi, Batol Karimi, Abbas Aghaei and Hamidreza Saeidi Brojeni

Authors’ reply - anaphylactic shock with methylprednisolone, Kounis syndrome and Hypersitivity to corticosteroids: a clinical paradox

In our letter, we comment the paper of Kounis et al., that highlights a poor-known clinical entity determined by systemic use of corticosteroids, the so-called “Kounis syndrome type I”. We appreciated and shar...

Authors: F. Porcaro, M. G. Paglietti, A. Diamanti, F. Petreschi, A. Schiavino, V. Negro, V. Pecora, A. Fiocchi and R. Cutrera

Survival and predictors among preterm neonates admitted at University of Gondar comprehensive specialized hospital neonatal intensive care unit, Northwest Ethiopia

Prematurity accounts about 1 million neonatal deaths worldwide and the second causes of both neonatal and under five-child mortality. Neonatal mortality accounts for 43% of under-five child mortality in Ethiop...

Authors: Ayenew Engida Yismaw, Abebaw Addis Gelagay and Malede Mequanent Sisay

Hepatomegaly and type 1 diabetes: a clinical case of Mauriac’s syndrome

Hepatic glycogenosis is characterized by excessive glycogen accumulation in hepatocytes and represents a complication of poor controlled type 1 diabetes. It can be caused by excessive insulin doses or recurren...

Authors: Fortunato Lombardo, Stefano Passanisi, Albino Gasbarro, Giovanni Tuccari, Antonio Ieni and Giuseppina Salzano

A modified physiologic test for bronchopulmonary dysplasia: a clinical tool for weaning from CPAP and/or oxygen-therapy the premature babies?

A physiologic test for estimating BPD rate has been developed by Walsh and collaborators. Actually there are not standard criteria for weaning from CPAP and/or oxygen therapy the premature babies. Aim of this ...

Authors: Giovanni Vento, Valentina Vendettuoli, Claudia Aurilia, Milena Tana, Chiara Tirone, Alessandra Lio, Piero Giuseppe Matassa, Francesca Priolo, Piero Catenazzi, Mirta Corsello, Enrico Zecca and Fabio Mosca