Articles

Digital screen time and its effect on preschoolers’ behavior in China: results from a cross-sectional study

The aims of the study were to determine the effects of electronic exposure on behaviors of preschoolers, which could provide scientific grounds to the control of digital screen time and usage of electronics.

Authors: Guodong Xie, Qianye Deng, Jing Cao and Qing Chang

High risk of macrosomia in newborns of immigrant mothers

In Italy live about 8.7% immigrants, which contribute to more than 15% of all deliveries taking place in Italy. We aimed to investigate whether newborns from high migratory pressure countries (HMPC) mothers ha...

Authors: Mario De Curtis, Leonardo Villani and Arianna Polo

FMF is not always “fever”: from clinical presentation to “treat to target”

Familial Mediterranean Fever, a monogenic autoinflammatory disease secondary to MEFV gene mutations in the chromosome 16p13, is characterized by recurrent self-limiting attacks of fever, arthritis, aphthous ch...

Authors: Maria Cristina Maggio and Giovanni Corsello

The efficacy of dopamine versus epinephrine for pediatric or neonatal septic shock: a meta-analysis of randomized controlled studies

The efficacy of dopamine versus epinephrine for pediatric or neonatal septic shock remains controversial. We conduct a meta-analysis to explore the influence of dopamine versus epinephrine on shock reversal fo...

Authors: Lingling Wen and Liangyin Xu

Epidemiology and drug allergy results in children investigated in allergy unit of a tertiary-care paediatric hospital setting

Drug Hypersensitivity Reactions (DHRs) are considered adverse effects of medications that resemble allergy symptoms. The reported positive clinical history of pediatric drug reactions is about 10%, however, af...

Authors: A. Piccorossi, G. Liccioli, S. Barni, L. Sarti, M. Giovannini, A. Verrotti, E. Novembre and F. Mori

Blood biomarkers differentiating viral versus bacterial pneumonia aetiology: a literature review

The goal of this literature review is to compare current studies regarding the accuracy of different serum markers in differentiating viral from bacterial pneumonia in the pediatric population with what is emp...

Authors: Jithin Thomas, Aiste Pociute, Rimantas Kevalas, Mantas Malinauskas and Lina Jankauskaite

Isolated auditory neuropathy at birth in congenital cytomegalovirus infection

Congenital cytomegalovirus (cCMV) infection is the most frequent non-genetic cause of sensorineural hearing-loss (SNHL) (i.e., hearing loss due to a cochlear and/or auditory nerve damage). It is widely accepte...

Authors: Fabio Natale, Mario De Curtis, Bianca Bizzarri, Maria Patrizia Orlando, Massimo Ralli, Giuseppina Liuzzi, Barbara Caravale, Francesco Franco, Aurelia Gaeta, Antonella Giancotti, Francesca Yoshie Russo and Rosaria Turchetta

A reflection on the role of genetics in the concept of “epileptic encephalopathy”, as emerged from the most recent ILEA classification of epilepsy

The International League Against Epilepsy (ILAE) has been working to standardize the epilepsy classifications for over a hundred years.

Authors: Angelo Russo and Giuseppe Gobbi

Prevalence and associated factors of anemia among full-term newborn babies at University of Gondar comprehensive specialized hospital, Northwest Ethiopia: a cross-sectional study

Anemia in newborn babies causes asymptomatic to an acute life-threatening event. If untreated, it leads to a delay in brain maturation, tissue hypoxia, and stunted growth. In Sub-Saharan Africa, its burden ran...

Authors: Tegenaw Tiruneh, Elias Shiferaw and Bamlaku Enawgaw

Does virtual reality reduce pain in pediatric patients? A systematic review

Virtual Reality (VR) as a tool for pain reduction is the research topic of several clinical trial for Randomized Controlled Trials despite its wide use in the daily clinical practice for non- pharmacological r...

Authors: Anna Maria Iannicelli, Daniele Vito, Concetta Anna Dodaro, Pasquale De Matteo, Rita Nocerino, Angela Sepe and Valeria Raia

Proton therapy in the most common pediatric non-central nervous system malignancies: an overview of clinical and dosimetric outcomes

Radiation therapy represents an important approach in the therapeutic management of children and adolescents with malignant tumors and its application with modern techniques – including Proton Beam Therapy (PB...

Authors: Angela Sardaro, Roberta Carbonara, Maria Fonte Petruzzelli, Barbara Turi, Marco Moschetta, Arnaldo Scardapane and Amato Antonio Stabile Ianora

A multi-etiological model of childhood obesity: a new biobehavioral perspective for prevention?

Current prevention strategies focusing only around the energy balance model have been found insufficient to tackle the childhood obesity epidemic. Originating from the paper by Baranowski et al., recently publ...

Authors: Giuliana Valerio and Sergio Bernasconi

Early onset retinal dystrophies: clinical clues to diagnosis for pediatricians

Inherited retinal dystrophies are major cause of severe progressive vision loss in children. Early recognition and diagnosis are essential for timely visual rehabilitation during the appropriate stages of the ...

Authors: Agnese Suppiej, Silvia Marino, Maria Eleonora Reffo, Veronica Maritan, Giovanna Vitaliti, Janette Mailo and Raffaele Falsaperla

Two case reports of fetal alcohol syndrome: broadening into the spectrum of cardiac disease to personalize and to improve clinical assessment

Fetal alcohol spectrum disorder (FASD) refers to a broad spectrum of disabilities, in infants and children, resulting from moderate to excessive prenatal alcohol exposure.

Authors: R. Onesimo, C. De Rose, A. B. Delogu, A. Battista, C. Leoni, S. Veltri, G. De Rosa and G. Zampino

Differential analysis of nutrient intake, insulin resistance and lipid profiles between healthy and premature thelarche Chinese girls

Premature thelarche (PT) is a benevolent ailment affecting young girls. Multiple factors are reported to correlate with this condition, but the mechanisms responsible for the onset of PT have not yet been full...

Authors: Yueqin Xu, Yan Li, Shuang Liang and Guimei Li

Severe congenital RYR1-associated myopathy complicated with atrial tachycardia and sinus node dysfunction: a case report

Cardiac arrhythmias are sometimes encountered in patients with hereditary myopathies and muscular dystrophies. Description of arrhythmias in myopathies and muscular dystrophies is very important, because arrhy...

Authors: Itaru Hayakawa, Yuichi Abe, Hiroshi Ono and Masaya Kubota

The effect of educational intervention based on BASNEF model for reducing internet addiction among female students: a quasi-experimental study

Adolescents and students are encountered with a challenge so-called “internet Addiction”. This issue affects both their physical and mental health, as well as their academic, social, and family performance. Th...

Authors: Batol Gholamian, Hossein Shahnazi and Akbar Hassanzadeh

75th Congress of the Italian Society of Pediatrics

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2019 Congress of the Italian Society of Neonatology

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High expression of miR-222-3p in children with Mycoplasma pneumoniae pneumonia

Mycoplasma pneumoniae is a leading cause of community-acquired pneumonia in children. However, its mechanism of pathogenesis is not fully understood, and microRNAs might play a role. This study aimed to explor...

Authors: Chu Chu, Xiaoli Lei, Yuqin Li, Yali Luo, Ying Ding, Weifang Zhou and Wei Ji

OPG/RANK/RANKL signaling axis in patients with type I diabetes: Associations with parathormone and vitamin D

Type 1 diabetes (T1D) has been associated with a higher fracture risk due to alterations in bone structure and metabolism. On the other hand, the important role of the RANKL/OPG/RANK signaling axis in bone phy...

Authors: Paraskevi Karalazou, Dimitrios Ntelios, Fani Chatzopoulou, Aikaterini Fragou, Maria Taousani, Konstantina Mouzaki, Assimina Galli-Tsinopoulou, Sofia Kouidou and Georgios Tzimagiorgis

PRRT2 gene variant in a child with dysmorphic features, congenital microcephaly, and severe epileptic seizures: genotype-phenotype correlation?

Mutations in Proline-rich Transmembrane Protein 2 (PRRT2) have been primarily associated with individuals presenting with infantile epilepsy, including benign familial infantile epilepsy, benign infantile epileps...

Authors: Piero Pavone, Giovanni. Corsello, Sung Yoon Cho, Xena Giada Pappalardo, Martino Ruggieri, Simona Domenica Marino, Dong Kyu Jin, Silvia Marino and Raffaele Falsaperla

Effectiveness of message-framing intervention on complementary feeding related behaviors among mothers with infants aged 4–8 months: a 3-arm randomized controlled trial

Complementary feeding from the age of 6 months along with breastfeeding is essential for the health of infants. The effect of educational interventions on preventing the early or late onset of complementary fe...

Authors: Ziba Rafieyan-Kopaei, Zohreh Fathian-Dastgerdi, Mohammad Javad Tarrahi and Fereshteh Zamani-Alavijeh

Italian guidelines for the prevention and management of dental trauma in children

Dental trauma is a frequent occurrence in children and adolescent and a correct diagnosis and treatment are essential for a favourable long-term prognosis. The present Guidelines aim to formulate evidence-base...

Authors: Maria Grazia Cagetti, Piero Alessandro Marcoli, Mario Berengo, Piero Cascone, Livio Cordone, Patrizia Defabianis, Osvalda De Giglio, Nicola Esposito, Antonio Federici, Alberto Laino, Alessandra Majorana, Michele Nardone, Vilma Pinchi, Silvia Pizzi, Antonella Polimeni, Maria Grazia Privitera…

Acute pain management in children: a survey of Italian pediatricians

Current guidelines recommend assessing and relieving pain in all children and in all instances; yet, in clinical practice, management is frequently suboptimal. We investigated the attitude of Italian family pe...

Authors: Gian Luigi Marseglia, Maria Alessio, Liviana Da Dalt, Maria Giuliano, Angelo Ravelli and Paola Marchisio

Long-term follow-up until early adulthood in autosomal dominant, complex SPG30 with a novel KIF1A variant: a case report

Pathogenic variants in KIF1A (kinesin family member 1A) gene have been associated with hereditary spastic paraplegia (HSP) type 30 (SPG30), encopassing autosomal dominant and recessive, pure and complicated forms...

Authors: Carlotta Spagnoli, Susanna Rizzi, Grazia Gabriella Salerno, Daniele Frattini and Carlo Fusco

Poor child complementary Feeding Practices in northwest Ethiopia: Finding from the Baseline Survey of Nutrition Project, 2016

Improving infant and young child feeding practices is critical to improved nutrition, health, and development of children. Ethiopia adopted the WHO recommendations of child feeding practices and developed the ...

Authors: Zegeye Abebe, Amare Tariku, Gashaw Andargie Bikes, Molla Mesele Wassie, Kedir Abdela Gonete, Tadesse Awoke, Ejigu Gebeye, Azeb Atnafu Gete, Melkie Edris Yesuf, Yigzaw Kebede, Kassahun Alemu, Abebaw Addis, Esmael Ali Muhammad, Solomon Mekonnen Abebe, Aysheshim Kasahun belew, Melkamu Tamir Hunegnaw…

Trends and determinants of teenage childbearing in Ethiopia: evidence from the 2000 to 2016 demographic and health surveys

Teenage childbearing among adolescents aged 15 to 19 is a common sexual and reproductive health (SRH) issue among young people, particularly in developing countries. It is associated with higher maternal and n...

Authors: Getachew Mullu Kassa, Ayodele O. Arowojolu, Akin-Tunde Ademola Odukogbe and Alemayehu Worku Yalew

Perinatal and newborn care in a two years retrospective study in a first level peripheral hospital in Sicily (Italy)

Two hundred seventy-five thousand maternal deaths, 2.7 million neonatal deaths, and 2.6 million stillbirths have been estimated in 2015 worldwide, almost all in low-income countries (LICs). Moreover, more than...

Authors: Gregorio Serra, Vincenzo Miceli, Salvatore Albano and Giovanni Corsello

Omalizumab and mepolizumab in the landscape of biological therapy for severe asthma in children: how to choose?

Severe asthma has a substantial epidemiological impact on children and biological treatments can be an option to take into account, as they target specific molecules and pathways involved in its pathogenesis. ...

Authors: Mattia Giovannini, Francesca Mori, Simona Barni, Maurizio de Martino and Elio Novembre

Determinants of neonatal sepsis among neonates in the northwest part of Ethiopia: case-control study

Neonatal sepsis is one of the leading causes of neonatal morbidity and mortality. Despite implementing of different preventive interventions, the burden of neonatal sepsis is reporting in different areas of Et...

Authors: Mulunesh Alemu, Mulatu Ayana, Hailemariam Abiy, Biniam Minuye, Wubet Alebachew and Aklilu Endalamaw

Media use during adolescence: the recommendations of the Italian Pediatric Society

The use of media device, such as smartphone and tablet, is currently increasing, especially among the youngest. Adolescents spend more and more time with their smartphones consulting social media, mainly Faceb...

Authors: Elena Bozzola, Giulia Spina, Margherita Ruggiero, Davide Vecchio, Cinthia Caruso, Mauro Bozzola, Anna Maria Staiano, Rino Agostiniani, Antonello Del Vecchio, Giuseppe Banderali, Diego Peroni, Alberto Chiara, Luigi Memo, Renato Turra, Giovanni Corsello and Alberto Villani

A child with a novel ACAN missense variant mimicking a septic arthritis

Heterozygous mutations of the ACAN gene have been associated with a broad spectrum of non-lethal skeletal dysplasias, called Aggrecanopathies. We report a case of a child with severe inflammatory elbow involvemen...

Authors: Angelo Florio, Riccardo Papa, Roberta Caorsi, Alessandro Consolaro, Roberto Gastaldi, Marco Gattorno and Paolo Picco

Factors affecting breast-feeding practice among a sample of Iranian women: a structural equation modeling approach

Breastfeeding is one of the most sensitive stages in the development of children, having many benefits for the mother and the child. The present study aimed to determine factors associated with breastfeeding i...

Authors: Reyhaneh Rafizadeh, Zahra Heidari, Mahmood Karimy, Fereshteh Zamani-Alavijeh and Marzieh Araban

Weight estimation in Paediatrics: how accurate is the Broselow-tape weight estimation in the Nigerian child

Determination of weight in children is an important aspect of their assessment. It has a wide range of usefulness including assessing their nutritional status and drug dose calculation. Despite its usefulness,...

Authors: Ogochukwu N. Iloh, Benedict Edelu, Kenechukwu K. Iloh, Obianuju O. Igbokwe, Ikenna K. Ndu, Obinna C. Nduagubam, Uzoamaka C. Akubuilo, Ijeoma N. Obumneme-Anyim, Joy N. Eze and Chidiebere D. I. Osuorah

Hexavalent vaccines in preterm infants: an update by Italian Society of Pediatric Allergy and Immunology jointly with the Italian Society of Neonatology

Hexavalent vaccines, protecting against six diseases (diphtheria, tetanus, pertussis [DTaP], poliovirus, hepatitis B virus [HBV], and Haemophilus influenzae type b [Hib], are routinely the standard of care in Eur...

Authors: E. Chiappini, C. Petrolini, C. Caffarelli, M. Calvani, F. Cardinale, M. Duse, A. Licari, S. Manti, A. Martelli, D. Minasi, M. Miraglia Del Giudice, GB. Pajno, C. Pietrasanta, L. Pugni, MA. Tosca, F. Mosca…

Early features of autism spectrum disorder: a cross-sectional study

Autism spectrum disorder is characterized by impairment in social interaction and communication along with repetitive, restricted, and stereotyped behaviors, interests and activities. It is important to detect...

Authors: Antonia Parmeggiani, Arianna Corinaldesi and Annio Posar

Microalbuminuria risks and glomerular filtration in children with sickle cell anaemia in Nigeria

Evidence of kidney damage is observed in children with sickle cell anaemia (SCA) and this continues through adulthood with progression to severe functional impairment in some. One of the earliest features of k...

Authors: I. E. Ocheke, S. Mohamed, E. S. Okpe, F. Bode-Thomas and M. I. McCullouch

Heterotopic pancreas in the gastrointestinal tract in children: a single-center experience and a review of the literature

Heterotopic pancreas, that is the abnormal localization of a well-differentiated pancreatic tissue, is a rare occurrence in pediatric patients. Most lesions are found incidentally; in some circumstances, the p...

Authors: Giorgio Persano, Noemi Cantone, Elisa Pani, Enrico Ciardini and Bruno Noccioli

Cortisol, leptin and free leptin index (FLI) in newborns in the first days of life and their importance for body weight programming

Birth weight and leptin seem to be the factors responsible for early programming of body weight in later life. A marker for leptin action is free leptin index (FLI), which depends on soluble leptin receptor (O...

Authors: Beata Kulik-Rechberger, Anna Maria Bury, Anna Rakuś-Kwiatosz and Iwona Beń-Skowronek

Effects of Lactobacillus reuteri DSM 17938 in preterm infants: a double-blinded randomized controlled study

Preterm infants have immature gastrointestinal tracts and poor immunity. In this study, the effects of Lactobacillus reuteri DSM 17938 first on early feeding tolerance, growth, and second on infection prevention ...

Authors: Xuewei Cui, Yongyan Shi, Siyang Gao, Xindong Xue and Jianhua Fu

Impact of the 2014 American Academy of Pediatrics recommendation and of the resulting limited financial coverage by the Italian Medicines Agency for palivizumab prophylaxis on the RSV-associated hospitalizations in preterm infants during the 2016–2017 epidemic season: a systematic review of seven Italian reports

The only pharmacologic prophylaxis against respiratory syncytial virus (RSV) infection in preterm infants is the humanized monoclonal antibody palivizumab. After the 2014 modification of the American Academy o...

Authors: Renato Cutrera, Andrea Wolfler, Simonetta Picone, Giovanni A. Rossi, Giuliana Gualberti, Rocco Merolla, Antonio Del Vecchio, Alberto Villani, Fabio Midulla and Andrea Dotta

NF1 microdeletion syndrome: case report of two new patients

17q11.2 microdeletions, which include the neurofibromatosis type 1 (NF1) gene region, are responsible for the NF1 microdeletion syndrome, observed in 4.2% of all NF1 patients. Large deletions of the NF1 gene and ...

Authors: Gregorio Serra, Vincenzo Antona, Giovanni Corsello, Federico Zara, Ettore Piro and Raffaele Falsaperla

Predictors of mortality among HIV exposed infants at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

In the era of highly active antiretroviral therapy, vertical HIV transmission has been decreased. This may increase fertility desire of HIV infected women and an increasing number of HIV exposed infants as a r...

Authors: Chalachew Adugna Wubneh, Aklilu Endalamaw and Nigusie Birhan Tebeje

Time to recovery and determinants of severe acute malnutrition among 6–59 months children treated at outpatient therapeutic programme in North Gondar zone, Northwest Ethiopia: a prospective follow up study

Despite the available interventions to tackle nutritional problems, there is scarce information on time to recovery and its determinants among children with SAM in Ethiopia.

Authors: Worku Nigussu Mamo, Terefe Derso, Kassahun Alemu Gelaye and Temesgen Yihunie Akalu

A new therapy in Epstein-Barr virus-associated lymphoproliferative disease: a case report and a revision of the literature

Systemic chronic active Epstein-Barr virus infection is an extremely rare childhood disease. Since chronic active Epstein-Barr virus infection can trigger the onset of Epstein-Barr virus-associated lymphoproli...

Authors: Lingling Xu, Hongjun Ba, Hongrong Lin, Liangying Zhong, Suping Li, Wen Tang, Zhiyong Ke and Ziyin Ye

Parental Mental Health, Fathers’ Involvement and Bedtime Resistance in Infants

Around the age of 6 months, difficulties in settling to sleep and frequent night awakenings are generally occurring in 20 to 30% of infants. According to the transactional model parental factors can play a sig...

Authors: Benedetta Ragni, Simona De Stasio, Daniela Barni, Simonetta Gentile and Rosaria Giampaolo

Safety and tolerability of Meningococcus B vaccine in patients with chronical medical conditions (CMC)

Invasive meningococcal disease is a serious global health threat in the world; in 2016, the European Centre for Disease Control and Prevention reported 3280 confirmed cases (including 304 deaths) of Invasive M...

Authors: L. Nicolosi, C. Rizzo, G. Castelli Gattinara, N. Mirante, E. Bellelli, C. Bianchini, V. Pansini and A. Villani

Can we still do something-and what? - for a seemingly missing syndrome?: “Yes we can”

In this letter, the authors compare the incidence of SUDI and SIDS in the Tuscany Region to the incidence reported by Campi and Bonati in their paper “Can we still do something-and what?- for a seemingly missi...

Authors: Raffaele Piumelli, Cinzia Arzilli, Niccolò Nassi, Marta Peruzzi, Carola-Maria Ernst and Cristina Salvatori

Neonatologist performed echocardiography (NPE) in Italian neonatal intensive care units: a national survey

Neonatologist performed echocardiography (NPE) has increasingly been used to assess the hemodynamic status in neonates. Aim of this survey was to investigate the utilization of NPE in Italian neonatal intensiv...

Authors: Iuri Corsini, Benjamim Ficial, Stefano Fiocchi, Federico Schena, Irma Capolupo, Rosa Maria Cerbo, Manuela Condò, Daniela Doni, Simona La Placa, Salvatore Porzio, Katia Rossi, Sabrina Salvadori and Marilena Savoia