Articles

The predictive value of urine specific gravity in the diagnosis of vasovagal syncope in children and adolescents

Vasovagal syncope (VVS) is a kind of common neurally mediated syncope in children and adolescents. Decreased blood volume is one of the pathogenesis of VVS. The diagnosis of VVS is mainly based on head-up tilt...

Authors: Ping Liu, Xingfang Zeng, Wanzhen Mei, Yuwen Wang, Runmei Zou and Cheng Wang

Assessing patients’ characteristics and treatment patterns among children with atopic dermatitis

Atopic dermatitis (AD) is the most common immune-mediated skin disease in childhood. Several treatment options for pediatric AD, both topical and systemic, are currently available. We carried out a single-cent...

Authors: Davide Geat, Mattia Giovannini, Gabriele Barlocco, Riccardo Pertile, Manuela Pace, Francesca Mori, Elio Novembre, Giampiero Girolomoni, Mario Cristofolini and Ermanno Baldo

Characteristics associated with clinical response to Comano thermal spring water balneotherapy in pediatric patients with atopic dermatitis

Several studies have investigated the efficacy of balneotherapy in atopic dermatitis (AD), including a pediatric open randomized clinical trial conducted at the Comano thermal spring water center, which showed...

Authors: Davide Geat, Mattia Giovannini, Ezio Gabriele Barlocco, Riccardo Pertile, Stefania Farina, Manuela Pace, Cesare Filippeschi, Giampiero Girolomoni, Mario Cristofolini and Ermanno Baldo

Clinical characteristics of children infected with SARS-CoV-2 in Italy

Since December 2019 coronavirus disease (COVID-19) emerged in Wuhan and spread rapidly worldwide. Despite the high number of people affected, data on clinical features and prognostic factors in children and ad...

Authors: Isabella Tarissi De Jacobis, Rosa Vona, Camilla Cittadini, Alessandra Marchesi, Laura Cursi, Lucrezia Gambardella, Alberto Villani and Elisabetta Straface

Correction to: A case report of Phelan-McDermid syndrome: preliminary results of the treatment with growth hormone therapy

An amendment to this paper has been published and can be accessed via the original article.

Authors: Rui Jin Xie, Tian Xiao Li, Chenyu Sun, Ce Cheng, Jinlin Zhao, Hua Xu and Yueying Liu

Evaluation of the relationship between NIRS (near-infrared spectroscopy) and optic nerve sheath diameter measurement in children with increased intracranial pressure: a pilot study

The increased intracranial pressure (ICP) syndrome may emerge depending on many different neurological factors and the early diagnosis and treatment are important for the prevention of neurologic damage and re...

Authors: Didar Arslan, Dinçer Yıldızdaş, Özden Özgür Horoz, Nagehan Aslan and Faruk İncecik

Impact of newborn screening for cystic fibrosis on clinical outcomes of pediatric patients: 10 years’ experience in Lodz Voivodship

Cystic Fibrosis newborn screening (CFNBS) is the optimal method to diagnose the disease during the asymptomatic period. The aim of the study was to determine how CFNBS affects long term clinical outcomes.

Authors: M. Olszowiec-Chlebna, E. Mospinek and J. Jerzynska

Emotional symptoms and their related factors in adolescents during the acute phase of Covid-19 outbreak in South Italy

Several studies have shown that during COVID-19 pandemic outbreak, emotional symptoms increased in the general population. Less is known about youths.

Authors: Simone Pisano, Gennaro Catone, Antonella Gritti, Luisa Almerico, Anna Pezzella, Pia Santangelo, Carmela Bravaccio, Raffaella Iuliano and Vincenzo Paolo Senese

Treating the symptom or treating the disease in neonatal seizures: a systematic review of the literature

The existing treatment options for neonatal seizures have expanded over the last few decades, but no consensus has been reached regarding the optimal therapeutic protocols. We systematically reviewed the avail...

Authors: Raffaele Falsaperla, Bruna Scalia, Andrea Giugno, Piero Pavone, Milena Motta, Martina Caccamo and Martino Ruggieri

Magnitude and associated factors of virological failure among children on ART in Bahir Dar Town public health facilities, Northwest Ethiopia: a facility based cross-sectional study

Despite the rapid scale-up of antiretroviral therapy, virologic failure has become global public health concern and challenge, especially in developing countries. Viral load monitoring is an important approach...

Authors: Belete Gelaw, Getasew Mulatu, Getasew Tesfa, Chalie Marew, Bogale Chekole and Animut Alebel

Cyclosporine A-related neurotoxicity after haploidentical hematopoietic stem cell transplantation in children with hematopathy

To evaluate cyclosporine A (CSA)-related neurotoxicity after haploidentical hematopoietic stem cell transplantation (HID-HSCT) in children with hematopathy.

Authors: Yong Wang, Yongzhi Zheng, Jingjing Wen, Jinhua Ren, Xiaohong Yuan, Ting Yang and Jianda Hu

Prevalence of children born small for gestational age with short stature who qualify for growth hormone treatment

Recombinant human growth hormone (rhGH) is approved in Europe as a treatment for short children born small for gestational age (SGA) since 2003. However, no study evaluated the prevalence of SGA children with ...

Authors: Gianluca Tamaro, Mariagrazia Pizzul, Giuliana Gaeta, Raffaella Servello, Marina Trevisan, Patricia Böhm, Paola Manera Ada Materassi, Anna Macaluso, Denis Valentini, Maria Chiara Pellegrin, Egidio Barbi and Gianluca Tornese

A novel de novo DDX3X missense variant in a female with brachycephaly and intellectual disability: a case report

De novo pathogenic variants in the DDX3X gene are reported to account for 1–3% of unexplained intellectual disability (ID) in females, leading to the rare disease known as DDX3X syndrome (MRXSSB, OMIM #300958). B...

Authors: Giada Moresco, Jole Costanza, Carlo Santaniello, Ornella Rondinone, Federico Grilli, Elisabetta Prada, Simona Orcesi, Ilaria Coro, Anna Pichiecchio, Paola Marchisio, Monica Miozzo, Laura Fontana and Donatella Milani

Isolated intestinal Ganglioneuromatosis: case report and literature review

Intestinal Ganglioneuromatosis (IG) is a rare disorder of the enteric nervous system. In pediatric age it is often associated with genetic syndromes such as Neurofibromatosis 1 (NF1), multiple endocrine neopla...

Authors: Angela Mauro, Letizia Zenzeri, Francesco Esposito, Giovanni Gaglione, Caterina Strisciuglio, Emanuela Pilozzi, Vito Domenico Corleto, Chiara Ziparo and Giovanni Di Nardo

Reply to: Regarding Iannicelli et al

Authors: Anna Maria Iannicelli, Daniele Vito, Concetta Anna Dodaro, Pasquale De Matteo, Rita Nocerino, Angela Sepe and Valeria Raia

Regarding Iannicelli et al.

Authors: Evelyn Chan and Paul Leong

Trends and determinants of breastfeeding within one hour in Ethiopia, further analysis of Ethiopian Demographic and Health Survey: multivariate decomposition analysis

Despite the substantial efforts to improve timely/early initiation of breastfeeding, avoidance of colostrum, and delayed initiation of breastfeeding remains a big challenge in developing countries. Therefore, ...

Authors: Tilahun Yemanu Birhan, Wullo Sisay Seretew and Muluneh Alene

The implications of complexity, systems thinking and philosophy for pediatricians

National service systems in child healthcare are characterized by diversity and complexity. Primary, secondary, tertiary and quaternary healthcare services create complex networks covering pediatric subspecial...

Authors: Jochen Ehrich, Jürgen Manemann, Velibor Tasic and Natale Gaspare DeSanto

Microplastics, environment and child health

Authors: Maria Elisabeth Street and Sergio Bernasconi

How to recognize and manage psychosomatic pain in the pediatric emergency department

Children and adolescents affected by somatization and somatic symptom disorder commonly refer to emergency services. Due to the absence of specific guidelines for the emergency setting and to a possible lack o...

Authors: Giorgio Cozzi, Annunziata Lucarelli, Fabio Borrometi, Ilaria Corsini, Eva Passone, Sara Pusceddu, Giuliana Morabito, Egidio Barbi and Franca Benini

Early-onset sepsis risk calculator: a review of its effectiveness and comparative study with our evidence-based local guidelines

According to most early-onset sepsis (EOS) management guidelines, approximately 10% of the total neonatal population are exposed to antibiotics in the first postnatal days with subsequent increase of neonatal ...

Authors: Gianluigi Laccetta, Massimiliano Ciantelli, Cristina Tuoni, Emilio Sigali, Mario Miccoli and Armando Cuttano

Pediatric routine vaccinations in the COVID 19 lockdown period: the survey of the Italian Pediatric Society

COVID-19 pandemic was responsible for disrupting routine immunization activities all over the world. Aim of the study was to investigate the reduced adherence to the national children vaccination schedule duri...

Authors: Rocco Russo, Elena Bozzola, Paolo Palma, Giovanni Corsello and Alberto Villani

Implications of SARS-COV-2 infection in the diagnosis and management of the pediatric gastrointestinal disease

Gastrointestinal diseases such as celiac disease, functional gastrointestinal disorders (FGIDs), inflammatory bowel disease (IBDs) and acute or chronic diarrhea are quite frequent in the pediatric population. ...

Authors: Valeria Dipasquale, Stefano Passanisi, Ugo Cucinotta, Antonio Cascio and Claudio Romano

First report of polymorphisms in MTRR, GATA4, VEGF, and ISL1 genes in Pakistani children with isolated ventricular septal defects (VSD)

Ventricular septal defects (VSDs) are malformations in the septum separating the heart’s ventricles. VSDs may present as a single anomaly (isolated/nonsyndromic VSD) or as part of a group of phenotypes (syndromic

Authors: Sumbal Sarwar, Farah Ehsan, Shabana, Amna Tahir, Mahrukh Jamil, Saleem Ullah Shahid, Asim Khan and Shahida Hasnain

Erythropoietin therapy in a case of neonatal anemia after exposure to natalizumab throughout pregnancy

Natalizumab is a monoclonal antibody approved for the treatment of patients with relapsing-remitting multiple sclerosis. According to the current clinical recommendations, its use during pregnancy should be ca...

Authors: Elisabetta Godano, Fabio Barra, Alessandra Allodi, Antonella Ferraiolo, Alice Laroni, Giovanni Novi, Giovanni Luigi Mancardi, Claudio Gustavino and Cesare Arioni

Real-time ultrasound for tip location of umbilical venous catheter in neonates: a pre/post intervention study

Recent guidelines advocate the use of real-time ultrasound to locate umbilical venous catheter tip. So far, training programs are not well established.

Authors: Serena Antonia Rubortone, Simonetta Costa, Alessandro Perri, Vito D’Andrea, Giovanni Vento and Giovanni Barone

Prognostic factors and predictors of outcome in children with autism spectrum disorder: the role of the paediatrician

Autism spectrum disorder is a complex condition with wide variation in type and severity that involves persistent challenges in social interaction, speech and nonverbal communication, restricted/repetitive beh...

Authors: Magda Di Renzo, Federico Bianchi di Castelbianco, Villani Alberto, Del Vecchio Antonio, Corsello Giovanni, Elena Vanadia, Massimiliano Petrillo, Trapolino Davide, Lidia Racinaro and Monica Rea

Postnatal growth of preterm infants during the first two years of life: catch-up growth accompanied by risk of overweight

Early postanal growth of preterm infants has many effects on early and late health. However, evidence on growth pattern in Chinese preterm infant population during early life is insufficient. This study aims t...

Authors: Junyan Han, Yuan Jiang, Jun Huang, Yue Zhang, Ying Zhang, Yi Zhang, Xiaotian Chen, Yun Li and Weili Yan

Frequency of asymptomatic carriers of SARS-CoV-2 among children and adults after school reopening

Children often develop an asymptomatic form of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), but it is debated if children are at higher risk than adults to be asymptomatic carriers of SARS-CoV...

Authors: Gregorio P. Milani, Paola Marchisio, Alessia Rocchi, Giuseppe Bertolozzi, Ludovico Furlan, Adriano La Vecchia, Carlo Agostoni and Giorgio Costantino

Incidence and risk factors of retinopathy of prematurity in an Italian cohort of preterm infants

Non-negligible differences in retinopathy of prematurity (ROP) and its risk factors between different neonatal intensive care units (NICUs) are reported. Our aim was to assess the incidence and risk factors fo...

Authors: Carlo Dani, Caterina Coviello, Fiorenza Panin, Saverio Frosini, Simonetta Costa, Velia Purcaro, Domenico Lepore and Giovanni Vento

Use of intravenous sodium bicarbonate in neonatal intensive care units in Italy: a nationwide survey

Metabolic Acidosis (MA) is a disturbance of the acid-base balance that can occur in preterm and critically ill term neonates due to different etiologies. Intravenous sodium bicarbonate (SB) has been traditiona...

Authors: Luca Massenzi, Roberto Aufieri, Silvia Donno, Rocco Agostino and Andrea Dotta

Failure to thrive in infant and toddlers: a practical flowchart-based approach in a hospital setting

Failure to thrive is a common reason for referral to paediatric services. Malnutrition or inadequate caloric intake is the most common cause, while organic form is unlikely in children who are asymptomatic and...

Authors: Roberto Franceschi, Caterina Rizzardi, Evelina Maines, Alice Liguori, Massimo Soffiati and Gianluca Tornese

Young child with painful edema and purpura: a case report

We reported the case of a two-old-year boy with a painful acute hemorrhagic edema. This is a self-limited benign condition: usually, affected children are well appearing and this strongly support the diagnosis...

Authors: Sarah Contorno, Giorgio Cozzi, Irene Berti, Egidio Barbi and Andrea Taddio

Impact of a diagnostic therapeutic educational pathway program for asthma management in preschool children

Preschool children with clinically-diagnosed asthma have a higher rate of emergency department visits and consume more resources for management than older children. However, no clinical trials have yet been pe...

Authors: Sebastiano Guarnaccia, Cristina Quecchia, Andrea Festa, Michele Magoni, Giuseppe Zenoni, Emanuele D’Agata, Valentina Brivio, Elena Zanardini, Carmelo Scarcella, Valeria Gretter, Susanna Facchetti, Cinzia Gasparotti, Ada Pluda, Malica Frassine, Rosa Maria Limina, Raffaele Spiazzi…

Autism spectrum disorder and anorexia nervosa: an Italian prospective study

Potential overlaps exist between psychopathological features of Anorexia Nervosa (AN) and Autism Spectrum Disorder (ASD). The impact of malnutrition on autistic traits in patients with AN should be considered....

Authors: Jacopo Pruccoli, Altea Solari, Letizia Terenzi, Elisabetta Malaspina, Marida Angotti, Veronica Pignataro, Paola Gualandi, Leonardo Sacrato, Duccio Maria Cordelli, Emilio Franzoni and Antonia Parmeggiani

COVID-19 quarantine: Psychological impact and support for children and parents

In response to the coronavirus (COVID-19) pandemic, national governments have imposed urgent sanitary and social measures to control the spread of the virus. One such measure is quarantine, which involves rest...

Authors: Francesco Demaria and Stefano Vicari

Management and outcome of benign acute childhood myositis in pediatric emergency department

Benign acute childhood myositis (BACM) is a self-limited syndrome associated with viral infections characterized by symmetric lower extremity pain typically affecting school-aged children. Evolution in rhabdom...

Authors: Giacomo Brisca, Marcello Mariani, Daniela Pirlo, Marta Romanengo, Angela Pistorio, Alberto Gaiero, Chiara Panicucci, Emanuela Piccotti and Claudio Bruno

Definition and prevalence of familial short stature

To verify the prevalence of novel definitions of familial short stature on a cross-sectional cohort of children referred for short stature when their height and that of both parents were measured.

Authors: Veronica Grigoletto, Alessandro Agostino Occhipinti, Maria Chiara Pellegrin, Fabio Sirchia, Egidio Barbi and Gianluca Tornese

Formula feeding practice and associated factors among mothers with infants 0–6 months of age in Addis Ababa, Ethiopia: a community-based cross-sectional study

Lack of exclusive breastfeeding during the first half-year of life is an important risk factor for childhood morbidity and mortality. Despite this, less than 40% of infants below 6 months are exclusively breas...

Authors: Alemnesh Abebe Taye, Wondwosen Asegidew, Mitku Mammo Taderegew, Yonas Girma Bizuwork and Betregiorgis Zegeye

Long-term outcome of a patient with Transcobalamin deficiency caused by the homozygous c.1115_1116delCA mutation in TCN2 gene: a case report

Transcobalamin deficiency is a rare autosomal recessive inborn error of cobalamin transport (prevalence: < 1/1000000) which clinically manifests in early infancy.

Authors: Francesco Martino, Alessandra Magenta, Maria Letizia Troccoli, Eliana Martino, Concetta Torromeo, Carolina Putotto and Francesco Barillà

The neonatal assessment manual score (NAME) for improving the clinical management of infants: a perspective validity study

The Neonatal Assessment Manual scorE (NAME) was developed to assist in the clinical management of infants in the neonatal ward by assessing their body’s compliance and homogeneity. The present study begins its...

Authors: Andrea Manzotti, Marco Chiera, Matteo Galli, Erica Lombardi, Simona La Rocca, Pamela Biasi, Jorge Esteves, Gianluca Lista and Francesco Cerritelli

“Impact of COVID-19 pandemic lockdown on early onset of puberty: experience of an Italian tertiary center”

At the end of 2019, an emerging atypical pneumonia called COVID-19 (coronavirus disease 2019), caused by the novel coronavirus defined as SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), was first...

Authors: Martina Verzani, Carla Bizzarri, Laura Chioma, Giorgia Bottaro, Stefania Pedicelli and Marco Cappa

Prevention starts from the crib: the pediatric point of view on detection of families at high cardiovascular risk

Cardiovascular disease (CVD) is one of the main causes of mortality and morbidity in Italy. Hypercholesterolemia is a modifiable CVD risk factor. The detection and treatment of hypercholesterolemia can modify ...

Authors: Maria Elena Capra, Cristina Pederiva, Giuseppe Banderali and Giacomo Biasucci

Central precocious puberty in a girl with LEGIUS syndrome: an accidental association?

Central precocious puberty is a condition characterized by precocious activation of the hypothalamic-pituitary-gonadal axis. It may be idiopathic or secondary to organic causes, including syndromes such as Neu...

Authors: Valentina Orlandi, Paolo Cavarzere, Laura Palma, Rossella Gaudino and Franco Antoniazzi

A case report of Phelan-McDermid syndrome: preliminary results of the treatment with growth hormone therapy

Phelan-McDermid syndrome (PMS), also known as 22q13.3 deletion syndrome, is a rare neurodevelopmental syndrome resulting from a deletion of the distal long arm of chromosome 22.

Authors: Rui Jin Xie, Tian Xiao Li, Chenyu Sun, Ce Cheng, Jinlin Zhao, Hua Xu and Yueying Liu

Pseudohypoparathyroidism: application of the Italian common healthcare-pathway for a homogeneous clinical approach and a shared follow up

Pseudohypoparathyroidism (PHP) represents a heterogeneous group of rare endocrine disorders caused by (epi) genetic abnormalities affecting the GNAS locus. It is mainly characterized by resistance to PTH and T...

Authors: Daniele Tessaris, Elisa Bonino, Giovanna Weber, Malgorzata Wasniewska, Domenico Corica, Marco Pitea, Giuseppe Scirè, Manuela Caruso-Nicoletti, Danilo Fintini and Luisa de Sanctis

Impact of novel coronavirus Disease-19 (COVID-19) pandemic in Italian pediatric emergency departments: a national survey

Coronavirus Disease-19 (COVID-19) has rapidly become a pandemic emergency, distressing health systems in each affected country. Preparation strategies for managing this pandemic have been keys to face the COVI...

Authors: Valentina Talarico, Luciano Pinto, Gian Luigi Marseglia, Antonella Centonze, Concetta Cristofaro, Rocco Reina, Agostino Nocerino, Riccardo Lubrano and Stefania Zampogna

Effects of glucocorticoid pulse therapy on thyroid function and thyroid antibodies in children with graves’ disease

Glucocorticoid treatment is used in children with Graves’ disease (GD) only in cases of exophthalmos. The purpose of this study was to observe the effects of glucocorticoid pulse therapy on thyroid function an...

Authors: Yanyan Hu, Yulin Man, Xuemei Sun and Yongzhen Xue

Breastfeeding and COVID-19 vaccination: position statement of the Italian scientific societies

The availability of a COVID-19 vaccine has raised the issue of its compatibility with breastfeeding. Consequently, the Italian Society of Neonatology (SIN), the Italian Society of Pediatrics (SIP), the Italian...

Authors: Riccardo Davanzo, Massimo Agosti, Irene Cetin, Antonio Chiantera, Giovanni Corsello, Luca A. Ramenghi, Annamaria Staiano, Marcello Tavio, Alberto Villani, Elsa Viora and Fabio Mosca

Diagnostic accuracy of a dynamically increased red blood cell distribution width in very low birth weight infants with serious bacterial infection

Serious bacterial infection (SBI) remains an important cause of morbidity and mortality in preterm infants. The objective of this study was to evaluate the dynamically increased value of the red cell distribut...

Authors: Bin-Fang Guo and Su-Zhen Sun