Hoffman JI. Incidence of congenital heart disease: I. Postnatal incidence. Pediatr Cardiol. 1995;16:103–13.
Article
CAS
PubMed
Google Scholar
Hoffman JI. Incidence of congenital heart disease: ii. Prenatal incidence. Pediatr Cardiol. 1995;16:155–65.
Article
CAS
PubMed
Google Scholar
Gilboa SM, Salemi JL, Nembhard WN, Fixler DE, Correa A. Mortality resulting from congenital heart disease among children and adults in the united states, 1999 to 2006. Circulation. 2010;122:2254–63.
Article
PubMed
PubMed Central
Google Scholar
Burn J, Brennan P, Little J, Holloway S, Coffey R, Somerville J, Dennis NR, Allan L, Arnold R, Deanfield JE, Godman M, Houston A, Keeton B, Oakley C, Scott O, Silove E, Wilkinson J, Pembrey M, Hunter AS. Recurrence risks in offspring of adults with major heart defects: results from first cohort of british collaborative study. Lancet. 1998;351:311–6.
Article
CAS
PubMed
Google Scholar
Fredriksen A, Meyer K, Ueland PM, Vollset SE, Grotmol T, Schneede J. Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism. Hum Mutat. 2007;28:856–65.
Article
CAS
PubMed
Google Scholar
Cordell HJ, Bentham J, Topf A, Zelenika D, Heath S, Mamasoula C, Cosgrove C, Blue G, Granados-Riveron J, Setchfield K, Thornborough C, Breckpot J, Soemedi R, Martin R, Rahman TJ, Hall D, van Engelen K, Moorman AF, Zwinderman AH, Barnett P, Koopmann TT, Adriaens ME, Varro A, George AL Jr, Dos Remedios C, Bishopric NH, Bezzina CR, O'Sullivan J, Gewillig M, Bu’Lock FA, Winlaw D, Bhattacharya S, Devriendt K, Brook JD, Mulder BJ, Mital S, Postma AV, Lathrop GM, Farrall M, Goodship JA, Keavney BD, et al. Nat Genet. 2013;45:822–4.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hu Z, Shi Y, Mo X, Xu J, Zhao B, Lin Y, Yang S, Xu Z, Dai J, Pan S, Da M, Wang X, Qian B, Wen Y, Wen J, Xing J, Guo X, Xia Y, Ma H, Jin G, Yu S, Liu J, Zhou Z, Wang X, Chen Y, Sha J, Shen HA. Genome-wide association study identifies two risk loci for congenital heart malformations in han chinese populations. Nat Genet. 2013;45:818–21.
Article
CAS
PubMed
Google Scholar
Goyette P, Pai A, Milos R, Frosst P, Tran P, Chen Z, Chan M, Rozen R. Gene structure of human and mouse methylenetetrahydrofolate reductase (mthfr). Mamm Genome. 1998;9:652–6.
Article
CAS
PubMed
Google Scholar
Hobbs CA, James SJ, Parsian A, Krakowiak PA, Jernigan S, Greenhaw JJ, Lu Y, Cleves MA. Congenital heart defects and genetic variants in the methylenetetrahydroflate reductase gene. J Med Genet. 2006;43:162–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Huhta JC, Hernandez-Robles JA. Homocysteine, folate, and congenital heart defects. Fetal Pediatr Pathol. 2005;24:71–9.
Article
CAS
PubMed
Google Scholar
Xuan C, Li H, Zhao JX, Wang HW, Wang Y, Ning CP, Liu Z, Zhang BB, He GW, Lun LM. Association between mthfr polymorphisms and congenital heart disease: a meta-analysis based on 9,329 cases and 15,076 controls. Sci Rep. 2014;4:7311.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chao CS, Wei J, Huang HW, Yang SC. Correlation between methyltetrahydrofolate reductase (mthfr) polymorphisms and isolated patent ductus arteriosus in taiwan. Heart Lung Circ. 2014;23:655–60.
Article
PubMed
Google Scholar
Christensen KE, Zada YF, Rohlicek CV, Andelfinger GU, Michaud JL, Bigras JL, Richter A, Dube MP, Rozen R. Risk of congenital heart defects is influenced by genetic variation in folate metabolism. Cardiol Young. 2013;23:89–98.
Article
PubMed
Google Scholar
Galdieri LC, Arrieta SR, Silva CM, Pedra CA, D'Almeida V. Homocysteine concentrations and molecular analysis in patients with congenital heart defects. Arch Med Res. 2007;38:212–8.
Article
CAS
PubMed
Google Scholar
Huang J, Mei J, Jiang L, Jiang Z, Liu H, Ding F. Mthfr rs1801133 c>t polymorphism is associated with an increased risk of tetralogy of fallot. Biomed Rep. 2014;2:172–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Koshy T, Venkatesan V, Perumal V, Hegde S, Paul SF. The a1298c methylenetetrahydrofolate reductase gene variant as a susceptibility gene for non-syndromic conotruncal heart defects in an indian population. Pediatr Cardiol. 2015;36:1470–5.
Article
PubMed
Google Scholar
Li D, Yu K, Ma Y, Liu Y, Ji L. Correlationship between congenital heart disease and polymorphism of mthfr gene. Wei Sheng Yan Jiu. 2015;44:933–8.
PubMed
Google Scholar
Locke AE, Dooley KJ, Tinker SW, Cheong SY, Feingold E, Allen EG, Freeman SB, Torfs CP, Cua CL, Epstein MP, MC W, Lin X, Capone G, Sherman SL, Bean LJ. Variation in folate pathway genes contributes to risk of congenital heart defects among individuals with down syndrome. Genet Epidemiol. 2010;34:613–23.
Article
PubMed
PubMed Central
Google Scholar
Obermann-Borst SA, van Driel LM, Helbing WA, de Jonge R, Wildhagen MF, Steegers EA, Steegers-Theunissen RP. Congenital heart defects and biomarkers of methylation in children: a case-control study. Eur J Clin Investig. 2011;41:143–50.
Article
CAS
Google Scholar
Sahiner UM, Alanay Y, Alehan D, Tuncbilek E, Alikasifoglu M. Methylene tetrahydrofolate reductase polymorphisms and homocysteine level in heart defects. Pediatr Int. 2014;56:167–72.
Article
CAS
PubMed
Google Scholar
Sayin Kocakap BD, Sanli C, Cabuk F, Koc M, Kutsal A. Association of mthfr a1298c polymorphism with conotruncal heart disease. Cardiol Young. 2015;25:1326–31.
Article
PubMed
Google Scholar
Storti S, Vittorini S, Iascone MR, Sacchelli M, Collavoli A, Ripoli A, Cocchi G, Biagini A, Clerico A. Association between 5,10-methylenetetrahydrofolate reductase c677t and a1298c polymorphisms and conotruncal heart defects. Clin Chem Lab Med. 2003;41:276–80.
Article
CAS
PubMed
Google Scholar
van Driel LM, Verkleij-Hagoort AC, de Jonge R, Uitterlinden AG, Steegers EA, van Duijn CM, Steegers-Theunissen RP. Two mthfr polymorphisms, maternal b-vitamin intake, and chds. Birth Defects Res A Clin Mol Teratol. 2008;82:474–81.
Article
CAS
PubMed
Google Scholar
Wang B, Liu M, Yan W, Mao J, Jiang D, Li H, Chen Y. Association of snps in genes involved in folate metabolism with the risk of congenital heart disease. J Matern Fetal Neonatal Med. 2013;26:1768–77.
Article
CAS
PubMed
Google Scholar
Xu J, Xu X, Xue L, Liu X, Gu H, Cao H, Qiu W, Hu Z, Shen H, Chen Y. Mthfr c.1793g>a polymorphism is associated with congenital cardiac disease in a chinese population. Cardiol Young. 2010;20:318–26.
Article
PubMed
Google Scholar
Zidan HE, Rezk NA, Mohammed D. Mthfr c677t and a1298c gene polymorphisms and their relation to homocysteine level in egyptian children with congenital heart diseases. Gene. 2013;529:119–24.
Article
CAS
PubMed
Google Scholar
Bozovic IB, Vranekovic J, Cizmarevic NS, Mahulja-Stamenkovic V, Prpic I, Brajenovic-Milic B. Mthfr c677t and a1298c polymorphisms as a risk factor for congenital heart defects in down syndrome. Pediatr Int. 2011;53:546–50.
Article
CAS
PubMed
Google Scholar
Gueant-Rodriguez RM, Gueant JL, Debard R, Thirion S, Hong LX, Bronowicki JP, Namour F, Chabi NW, Sanni A, Anello G, Bosco P, Romano C, Amouzou E, Arrieta HR, Sanchez BE, Romano A, Herbeth B, Guilland JC, Mutchinick OM. Prevalence of methylenetetrahydrofolate reductase 677t and 1298c alleles and folate status: a comparative study in mexican, west african, and european populations. Am J Clin Nutr. 2006;83:701–7.
CAS
PubMed
Google Scholar
Kapusta L, Haagmans ML, Steegers EA, Cuypers MH, Blom HJ, Eskes TK. Congenital heart defects and maternal derangement of homocysteine metabolism. J Pediatr. 1999;135:773–4.
Article
CAS
PubMed
Google Scholar
Feng Y, Wang S, Chen R, Tong X, Wu Z, Mo X. Maternal folic acid supplementation and the risk of congenital heart defects in offspring: a meta-analysis of epidemiological observational studies. Sci Rep. 2015;5:8506.
Article
CAS
PubMed
PubMed Central
Google Scholar
Smedts HP, Rakhshandehroo M, Verkleij-Hagoort AC, de Vries JH, Ottenkamp J, Steegers EA, Steegers-Theunissen RP. Maternal intake of fat, riboflavin and nicotinamide and the risk of having offspring with congenital heart defects. Eur J Nutr. 2008;47:357–65.
Article
CAS
PubMed
Google Scholar
Verkleij-Hagoort AC, de Vries JH, Ursem NT, de Jonge R, Hop WC, Steegers-Theunissen RP. Dietary intake of b-vitamins in mothers born a child with a congenital heart defect. Eur J Nutr. 2006;45:478–86.
Article
CAS
PubMed
Google Scholar